Results 101 to 110 of about 3,826 (176)

Matrine derivate MASM protects murine MC3T3-E1 osteoblastic cells against dexamethasone-induced apoptosis via the regulation of USP14/p53

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Matrine derivative MASM (M19) is a quinolizine alkaloid with diverse pharmacological effects including preventing postmenopausal osteoporosis. In the current study, we observed that pretreatment with M19 inhibited cell apoptosis of murine osteoblastic ...
Panyu Zhou, Demeng Xia, Yang Wang, Hongdi Lv, Ziqin Wang, Malcolm Xing, Qingjie Zhao, Shuogui Xu   +7 more
doaj   +1 more source

USP14/S100A11 axis promote colorectal cancer progression by inhibiting cell senescence. [PDF]

Cell Death Dis
The aberrant expression of S100A11 has been identified in various malignancies but its functional roles and underlying mechanisms in colorectal cancer (CRC) have not been fully elucidated.
Huang Y, Tang X, Xie H, Wu Z, Jin L, Zhang L, Lin X, Zhou H, Zou J.   +8 more
europepmc   +2 more sources

Structures of USP2 and USP14, modeled with ubiquitin and ISG15.

, 2013
Both USP2 and USP14 accommodate ubiquitin (green) in a shallow groove, measuring approximately 25–30 Å in diameter (view from top shown in the upper panels, view from front shown in the lower panels).
Daniël Blom (32523), Paul J. Galardy (32524), André Catic (32520), Hidde L. Ploegh (32525), Edda Fiebiger (32521), Gregory A. Korbel (32522)   +5 more
core   +1 more source

Confirmation that ubiquitinated β-catenin accumulates in USP14 C114A expressing cells.

, 2019
(A) Immunoblot showing USP14 C114A increases the total protein level of β-catenin in cells. Note the smearing of the β-catenin band in the C114A lane. (B) Quantification from (A). n = 6, * P P < 0.01, error bars represent SEM.
Chandler A. Walker (2185126), Peter Doig (1550449), Victoria Korboukh (1330497), Nicholas J. Brandon (1701649), Jayashree Chadchankar (7840889), Leslie C. Conway (7023941), Steve J. Jacobsen (7840892), Stephen J. Moss (2794006), Qi Wang (22418), Heike J. Wobst (4028465)   +9 more
core   +1 more source

USP14 inhibition promotes DNA damage repair and represses ovarian granulosa cell senescence in premature ovarian insufficiency

Journal of Translational Medicine
Background Premature ovarian insufficiency (POI) is a condition characterized by a substantial decline or loss of ovarian function in women before the age of 40.
Lin-Zi Ma, Ao Wang, Yun-Hui Lai, Jun Zhang, Xiao-Fei Zhang, Shi-Ling Chen, Xing-Yu Zhou   +6 more
doaj   +1 more source

A novel role for USP14 in regulating non-proteolytic ubiquitin signaling

, 2015
Loss of the deubiquitinating enzyme (DUB) USP14 in the ataxia (axJ) mice leads to altered neuromuscular junction (NMJ) structure, reduced synaptic transmission at the NMJ, and decreased mobility.
Vaden, Jada Hallengren
core  

The Role and Importance of Deubiquitinase Usp14 in MHC Class I Antigen Presentation

Major histocompatibility complex class I (MHC I) molecules are essential for antigen presentation and immune surveillance, and their expression is tightly regulated by multiple cellular pathways.
Badger, Cassie
core  

Deubiquitinase USP14 is upregulated in Crohn's disease and inhibits the NOD2 pathway mediated inflammatory response in vitro

European Journal of Histochemistry
The nucleotide binding oligomerization domain containing 2 (NOD2) protein and its ligand N-acetyl muramyl dipeptide (MDP) are crucially involved in Crohn’s disease (CD).
Mengling Li, Yan Zhao, Jiayi Zhang, Wang Jiang, Siyuan Peng, Jinyue Hu, Yueming Shen   +6 more
doaj   +1 more source

USP14 wt Allele [PDF]

, 2020
openaire   +1 more source

USP14 targets FABP5-mediated ferroptosis to promote proliferation and cisplatin resistance of HNSCC

Clinical and Translational Oncology
Abstract Background Head and neck squamous cell carcinoma (HNSCC) ranks among the most lethal solid tumors in humans, with a five-year survival rate hovering around 50%. The limited understanding of its biological foundation has hindered the development of efficacious targeted therapeutics.
Jiaxin Qian, Zitong Zhao, Liying Ma, Wensheng Liu, Yongmei Song   +4 more
openaire   +2 more sources