Results 101 to 110 of about 4,153 (179)

Inhibition of USP14 induces gastric cancer apoptosis and reduces resistance to 5-FU

, 2023
Deubiquitinating enzymes (DUBs)는 ubiquitin-proteasome system (UPS)의 필수 구성 요소로 기질 단백질에서 유비퀴틴을 잘라내어 해당 단백질의 분해를 억제하거나 활성도를 조절하는 등 다양한 기능을 가지고 있다. Ubiquitin-specific protease14 (USP14)는 DUB 중 하나로, 위암을 포함한 다양한 암의 형성 과정에서 그 역할에 대한 연구들이 진행중에 있다. 이번 연구에서 USP14의
이미예
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The Function of Drosophila USP14 in Endoplasmic Reticulum Stress and Retinal Degeneration in a Model for Autosomal Dominant Retinitis Pigmentosa

, 2020
Endoplasmic reticulum (ER) stress and its adaptive cellular response, the unfolded protein response (UPR), are involved in various diseases including neurodegenerative diseases, metabolic diseases, and even cancers.
Min-Ji Kang, Jung-Eun Park, Thị Xuân Thùy Trần, Nayoung Park, Jeonghun Yeom, Kyunggon Kim, 쩐 티 수언 투이, 김경곤, 강민지, 박나영, 박정은, 염정훈   +11 more
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HSPA9 contributes to tumor progression and ferroptosis resistance by enhancing USP14-driven SLC7A11 deubiquitination in multiple myeloma

Summary: Ferroptosis, a regulated cell death triggered by overload-dependent lipid peroxidation, is implicated in multiple human cancers. The mechanisms underlying ferroptosis in multiple myeloma (MM) remain enigmatic.
Wei Hua, Lijuan Chen, Yuan Xia, Min Shi, Na Shen, Xuxing Shen   +5 more
core   +1 more source

Targeting the TRIM14/USP14 axis enhances radiotherapy efficacy by inducing GPX4 degradation and disrupting ferroptotic defense in HCC

Cell Death and Disease
Radiation resistance constitutes a formidable impediment in the treatment paradigm for hepatocellular carcinoma (HCC). Deubiquitinases (DUBs) exhibit notable efficacy in modulating cellular responses to stress and exogenous interventions, endowed with ...
Xin Yue, Zhen Xiang, Yang Yi, Xuecen Wang, Weilin Zhou, Weijian Wu, Wenjing Qin, Yuxuan Zhao, Xianzhang Bu, Zhenwei Peng   +9 more
doaj   +1 more source

The Cullin3–Ring E3 ubiquitin ligase complex and USP14 regulate spastin-mediated microtubule severing and promotion of neurite outgrowth

Neural Regeneration Research
Post-translational modification of spastin enables precise spatiotemporal control of its microtubule severing activity. However, the detailed mechanism by which spastin turnover is regulated in the context of neurite outgrowth remains unknown.
Zhenbin Cai, Hui Wu, Tao Jiang, Ao Ma, Zhichao Meng, Jiehao Zhu, Hongsheng Lin, Yaozhong Liang, Guowei Zhang, Minghui Tan   +9 more
doaj   +1 more source

USP14 inhibition promotes DNA damage repair and represses ovarian granulosa cell senescence in premature ovarian insufficiency

Journal of Translational Medicine
Background Premature ovarian insufficiency (POI) is a condition characterized by a substantial decline or loss of ovarian function in women before the age of 40.
Lin-Zi Ma, Ao Wang, Yun-Hui Lai, Jun Zhang, Xiao-Fei Zhang, Shi-Ling Chen, Xing-Yu Zhou   +6 more
doaj   +1 more source

Characterization of Usp14 in the nmf375 mice.

, 2013
A, Schematic diagram of Usp14 cDNA species amplified. Open box indicates exonic sequence, lower case letters denote intronic sequence, grey box indicates intronic sequence maintained in mature transcript, angled lines represent splicing pattern.
Jennifer A. Watson (301186), Lynn E. Dobrunz (301197), Jada J. Hallengren (497831), Scott M. Wilson (260109), Brandon J. Walters (301187), Ludwig Francillon (497832), Andrea G. Marshall (497830), Julie A. Wilson (301192), Scott E. Phillips (301188)   +8 more
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Insights into the potential role of BMSCs-exo delivered USP14 on SIRT1 deubiquitination in Staphylococcus aureus-induced model of osteomyelitis

Journal of Orthopaedic Surgery and Research
Osteomyelitis resulting from a traumatic fracture is a recurrent and difficult-to-treat bone infection. Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme, and Sirtuin-1 (SIRT1), an NAD+-dependent deacetylase, both play critical roles in ...
Jun Yu, Ming Yang, Yun Jin, Kaijie Yang, Haibo Yang   +4 more
doaj   +1 more source

PKCiota Inhibits the Ferroptosis of Esophageal Cancer Cells via Suppressing USP14-Mediated Autophagic Degradation of GPX4

Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignant tumors, and the mechanisms underlying the anti-ferroptosis of esophageal cancer cells are still largely unclear.
Xin Jin, Zhi-Zhou Shi, Wen-Ting Li, Sheng-Jie Song, Jie Bai, Hao Tao, Ze-Wen Fan, Wen Jiang   +7 more
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USP14 wt Allele [PDF]

, 2020
openaire   +1 more source