Results 111 to 120 of about 3,826 (176)

A model showing the effects of inactive USP14 and inactive UCHL5 at the proteasome.

, 2019
(A) Venn diagram of the ubiquitinated proteins accumulated in USP14 C114A and UCHL5 C88A expressing cells. (B) Inactive USP14 C114A causes accumulation of specific substrates (Ub)n-X including ubiquitinated β-catenin.
Chandler A. Walker (2185126), Peter Doig (1550449), Victoria Korboukh (1330497), Nicholas J. Brandon (1701649), Jayashree Chadchankar (7840889), Leslie C. Conway (7023941), Steve J. Jacobsen (7840892), Stephen J. Moss (2794006), Qi Wang (22418), Heike J. Wobst (4028465)   +9 more
core   +1 more source

USP14/UCHL5 Inhibitor VLX1570 [PDF]

, 2020
openaire   +1 more source

Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment

Acta Pharmacologica Sinica
Ubiquitin-specific protease 14 (USP14) is a crucial modulator of proteasomal function and cellular proteostasis, which plays an important role in the development and progression of various cancers including colorectal cancer (CRC). In this study we screened 670 covalent compounds using the in vitro Ub-AMC hydrolysis assay, and identified AKOS ...
Lu, Bin, Sun, Yi-yun, Zhou, Jia-hao, Chen, Dan-ni, Guo, Yue, Chen, Yu-lu, Pan, Cheng-hao, Chen, Zheng-yang, He, Qiao-jun, Yuan, Meng, Cao, Ji, Jiang, Li, Yang, Bo   +12 more
openaire   +3 more sources

The Phenotypic Expression Of Usp14 Deficiency Is Dependent Upon Genetic Background

, 2013
The ubiquitin proteasome system (UPS) plays a critical role in regulating a diversity of cellular processes that are essential to neuronal function, such as synaptic transmission, axon guidance, and neurite outgrowth.
Marshall, Andrea Gail
core  

Novel roles of the protein deubiquitinase USP14 in proteostasis regulation and cell stress responses

Ubiquitin specific protease-14 (USP14) is a deubiquitinating enzyme that adaptively regulates proteostasis to determine the fate of cellular processes and their characteristics.
Srinivasan, Vignesh
core  

USP14 promotes osteoarthritis progression by deubiquitinating FZD8 to activate the Wnt/β-catenin signaling pathway

Background: Osteoarthritis (OA) is a chronic degenerative disease and associated with multiple pathogenic factors, such as old age, heredity, obesity, mechanical damage and inflammatory gene mutation.
Qiang Sun, Yongfeng Chen, Huayi Wang, Tiancheng Ma, Xiaochao Chen, Yuanrui Wang   +5 more
core   +1 more source

PKCiota Inhibits the Ferroptosis of Esophageal Cancer Cells via Suppressing USP14-Mediated Autophagic Degradation of GPX4

Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignant tumors, and the mechanisms underlying the anti-ferroptosis of esophageal cancer cells are still largely unclear.
Xin Jin, Zhi-Zhou Shi, Wen-Ting Li, Sheng-Jie Song, Jie Bai, Hao Tao, Ze-Wen Fan, Wen Jiang   +7 more
core   +1 more source

ADORA2B, deubiquitinated by USP14, facilitates IL-1β-induced chondrocyte apoptosis, ferroptosis and inflammation to accelerate osteoarthritis process. [PDF]

Medicine (Baltimore)
Li Z, Zhang P, Ouyang C, Shen Z, Guo G.
europepmc   +1 more source

Disrupting USP14-mediated PARP1 dynamics reinstates MIC-A/B-driven antigen-independent CD8⁺ T cell killing in glioma. [PDF]

Sci Adv
Wang M, Yu S, Zhang C, Cheng Q, Gong Z, Li X, Huang T, Wang X, Jiang X, Li J.   +9 more
europepmc   +1 more source

Expanding the targeted protein degradation approach with small molecule chimeras directed to the 26S proteasome. [PDF]

Nat Commun
Casasampere M, Carneros H, Roda T, Zuin A, Gallisà-Suñé N, González-Artero A, Coll-Martínez B, Abad JL, Alqahtani A, Casas J, Fernández-Nogueira P, Delgado A, Bujons J, Fabriàs G, Crosas B.   +14 more
europepmc   +1 more source