Results 111 to 120 of about 4,153 (179)

Additional file 1: of Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide

, 2019
Figure S1. Enzalutamide induced-antiproliferation is regulated by silencing AR or overexpressing USP14.
Chuyi Huang (1820812), Xuejun Wang (174299), Xiaohong Xia (4417822), Yuan Liu (88411), Jinchan He (6738224), Zhiqiang Guo (519788), Jinbao Liu (292973), Hongbiao Huang (292949), Yuning Liao (6581960), Lili Jiang (65114)   +9 more
core   +1 more source

USP14/UCHL5 Inhibitor VLX1570 [PDF]

, 2020
openaire   +1 more source

USP14 deficiency inhibits neointima formation following vascular injury via degradation of Skp2 protein

Cell Death Discovery
Ubiquitin-proteasome system (UPS) is involved in vascular smooth muscle cell (VSMC) proliferation. Deubiquitinating enzymes (DUBs) have an essential role in the UPS-regulated stability of the substrate; however, the function of DUBs in intimal ...
Xiaohong Xia, Xiaolin Liu, Qiong Xu, Jielei Gu, Sisi Ling, Yajing Liu, Rongxue Li, Min Zou, Siqin Jiang, Zhiwei Gao, Canshan Chen, Shiming Liu, Ningning Liu   +12 more
doaj   +1 more source

Novel roles of the protein deubiquitinase USP14 in proteostasis regulation and cell stress responses

Ubiquitin specific protease-14 (USP14) is a deubiquitinating enzyme that adaptively regulates proteostasis to determine the fate of cellular processes and their characteristics.
Srinivasan, Vignesh
core  

Identification and verification of diagnostic biomarkers for deep infiltrating endometriosis based on machine learning algorithms

Journal of Biological Engineering
This study addresses the challenges in the early diagnosis of deep infiltrating endometriosis (DIE) by exploring the potential role of the deubiquitinating enzyme USP14.
Shanping Shi, Chao Huang, Xiaojian Tang, Hua Liu, Weiwei Feng, Chen Chen   +5 more
doaj   +1 more source

Targeting USP14 sensitizes glioma to radiotherapy through exacerbated reactive oxygen species accumulation. [PDF]

Med Gas Res
Liu X, Shen L, Lu Y, Wang Z, Yuan S, Gu H, Qian J.   +6 more
europepmc   +1 more source

Ubiquitin-specific proteases and the immune microenvironment in cervical cancer: mechanistic evidence, immunotherapy resistance, and therapeutic perspectives. [PDF]

Neoplasia
Zhang Y, Zhu L, Xia L, Cheng H, Zhu W, Wang H.   +5 more
europepmc   +1 more source

Deubiquitinating Enzymes in Alzheimer's Disease: From Protein Homeostasis to Diverse Pathological Processes. [PDF]

Biomolecules
Shi X, Chen G, Wang X, Ma R, Li G.
europepmc   +1 more source

Targeting USP14/UCHL5: A Breakthrough Approach to Overcoming Treatment-Resistant FLT3-ITD-Positive AML

FMS-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations in acute myeloid leukemia (AML) are associated with poor prognosis and therapy resistance.
Hideki Jose Amemiya, Yoshihiro Umezawa, Shuji Tohda, Hiroki Fujiwara, Ayako Nogami, Toshikage Nagao   +5 more
core   +1 more source

Diabetic cardiomyopathy as a disorder of proteostatic maladaptation: context-dependent ubiquitin-specific protease networks. [PDF]

Front Cell Dev Biol
Meng X, Guo S, Lin H, Li R, Peng W, Sun L, Shi X, Yang L.   +7 more
europepmc   +1 more source