Results 1 to 10 of about 50,060 (264)
Mitophagy in neurological disorders [PDF]
Journal of Neuroinflammation, 2021 Selective autophagy is an evolutionarily conserved mechanism that removes excess protein aggregates and damaged intracellular components. Most eukaryotic cells, including neurons, rely on proficient mitophagy responses to fine-tune the mitochondrial ...
Lijun Zhang, Lei Dai, Deyuan Li
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Mitophagy and Neuroprotection [PDF]
Trends in Molecular Medicine, 2020 Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms.
Lou, Guofeng +5 more
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International Journal of Molecular Sciences, 2020 Stress mechanisms have long been associated with neuronal loss and neurodegenerative diseases. The origin of cell stress and neuronal loss likely stems from multiple pathways. These include (but are not limited to) bioenergetic failure, neuroinflammation, and loss of proteostasis.
Natalie Swerdlow, Heather Wilkins
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Mitophagy in Human Diseases [PDF]
International Journal of Molecular Sciences, 2021 Mitophagy is a selective autophagic process, essential for cellular homeostasis, that eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays an important role during development and is fundamental in highly differentiated post-mitotic cells that are highly dependent on aerobic metabolism, such as neurons, muscle ...
Laura Doblado +6 more
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Mitophagy for cardioprotection
Basic Research in Cardiology, 2023 AbstractMitochondrial function is maintained by several strictly coordinated mechanisms, collectively termed mitochondrial quality control mechanisms, including fusion and fission, degradation, and biogenesis. As the primary source of energy in cardiomyocytes, mitochondria are the central organelle for maintaining cardiac function.
Allen Sam Titus +3 more
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PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease
Cell Death and Disease, 2022 A persistent accumulation of damaged mitochondria is part of prion disease pathogenesis. Normally, damaged mitochondria are cleared via a major pathway that involves the E3 ubiquitin ligase parkin and PTEN-induced kinase 1 (PINK1) that together initiate ...
Jie Li +12 more
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Cancer & Metabolism, 2015 Mitophagy is a selective form of macro-autophagy in which mitochondria are selectively targeted for degradation in autophagolysosomes. Mitophagy can have the beneficial effect of eliminating old and/or damaged mitochondria, thus maintaining the integrity of the mitochondrial pool.
Chourasia, Aparajita H +2 more
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Frontiers in Cellular Neuroscience, 2023 Mitochondrial dysfunction is associated with ototoxicity, which is caused by external factors. Mitophagy plays a key role in maintaining mitochondrial homeostasis and function and is regulated by a series of key mitophagy regulatory proteins and signaling pathways.
Hezhou Han +7 more
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Redox Biology, 2021 Mitochondrial dysfunction is a fundamental challenge in septic cardiomyopathy. Mitophagy and the mitochondrial unfolded protein response (UPRmt) are the predominant stress-responsive and protective mechanisms involved in repairing damaged mitochondria ...
Yue Wang +5 more
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Open Medicine, 2021 Mitophagy affects the activation of hepatic stellate cells (HSCs). Mitochondria-targeted ubiquinone (MitoQ) is a mitochondria-targeted antioxidant that reduces the production of intracellular reactive oxygen species (ROS).
Dou Shi-Ying +7 more
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