Results 1 to 10 of about 63,946 (250)
Mitophagy Regulation Following Myocardial Infarction
Cells, 2022 Mitophagy, which mediates the selective elimination of dysfunctional mitochondria, is essential for cardiac homeostasis. Mitophagy is regulated mainly by PTEN-induced putative kinase protein-1 (PINK1)/parkin pathway but also by FUN14 domain-containing 1 (
Annie Turkieh +3 more
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A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy [PDF]
Cell Reports, 2019 Summary: Degradation of mitochondria by selective autophagy, termed mitophagy, contributes to the control of mitochondrial quality. Bcl2-L-13 is a mammalian homolog of Atg32, which is an essential mitophagy receptor in yeast.
Tomokazu Murakawa +5 more
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Decoding Mitophagy in Breast Cancer: Biological Mechanisms, Dual Roles, and Clinical Implications [PDF]
CellsMitophagy is a selective form of autophagy, essential to maintain cellular homeostasis by removing damaged and dysfunctional mitochondria. Several lines of evidence suggest that defective mitophagy is associated with various diseases, including breast ...
Silvia Zunico +10 more
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PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease
Cell Death and Disease, 2022 A persistent accumulation of damaged mitochondria is part of prion disease pathogenesis. Normally, damaged mitochondria are cleared via a major pathway that involves the E3 ubiquitin ligase parkin and PTEN-induced kinase 1 (PINK1) that together initiate ...
Jie Li +12 more
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Redox Biology, 2021 Mitochondrial dysfunction is a fundamental challenge in septic cardiomyopathy. Mitophagy and the mitochondrial unfolded protein response (UPRmt) are the predominant stress-responsive and protective mechanisms involved in repairing damaged mitochondria ...
Yue Wang +5 more
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Open Medicine, 2021 Mitophagy affects the activation of hepatic stellate cells (HSCs). Mitochondria-targeted ubiquinone (MitoQ) is a mitochondria-targeted antioxidant that reduces the production of intracellular reactive oxygen species (ROS).
Dou Shi-Ying +7 more
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Chemical mitophagy modulators: Drug development strategies and novel regulatory mechanisms
Pharmacological Research, 2023 Maintaining mitochondrial homeostasis is a potential therapeutic strategy for various diseases, including neurodegenerative diseases, cardiovascular diseases, metabolic disorders, and cancer. Selective degradation of mitochondria by autophagy (mitophagy)
Yu Dong +10 more
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Mitophagy in neurological disorders
Journal of Neuroinflammation, 2021 Selective autophagy is an evolutionarily conserved mechanism that removes excess protein aggregates and damaged intracellular components. Most eukaryotic cells, including neurons, rely on proficient mitophagy responses to fine-tune the mitochondrial ...
Lijun Zhang, Lei Dai, Deyuan Li
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Dysfunctional Mitochondria Clearance in Situ: Mitophagy in Obesity and Diabetes-Associated Cardiometabolic Diseases [PDF]
Diabetes & Metabolism JournalSeveral mitochondrial dysfunctions in obesity and diabetes include impaired mitochondrial membrane potential, excessive mitochondrial reactive oxygen species generation, reduced mitochondrial DNA, increased mitochondrial Ca2+ flux, and mitochondrial ...
Songling Tang +8 more
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Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN
Cells, 2022 The elimination of intracellular components by autophagy maintains metabolic homeostasis and is a quality-control pathway that enables organelle regeneration.
Po-Yuan Ke +2 more
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