BNIP3 in melanoma: isn’t it IRONic? [PDF]
Molecular & Cellular Oncology, 2021 Melanoma cells exploit mitophagy and hypoxia signaling to promote their growth. In a recent study, we found that loss of B-cell lymphoma 2 (BCL-2)/adenovirus E1B 19kDa protein-interacting protein 3 (BNIP3) curbed Hypoxia Inducible Factor 1 alpha (HIF-1α)
Mónica Vara-Pérez, Patrizia Agostinis
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ULK1 promotes mitophagy via phosphorylation and stabilization of BNIP3 [PDF]
Scientific Reports, 2021 UNC51-like kinase-1 (ULK1) is the catalytic component of the autophagy pre-initiation complex that stimulates autophagy via phosphorylation of ATG14, BECLN1 and other autophagy proteins.
Logan P. Poole +3 more
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Targeting REV-ERBα/BNIP3 axis attenuates pulmonary arterial hypertension by repressing mitophagy in mice [PDF]
Nature CommunicationsPulmonary arterial hypertension (PAH) is a life-threatening metabolic disorder. Nuclear receptors REV-ERBα and REV-ERBβ are established regulators of circadian rhythm and metabolic homeostasis, however their roles in PAH remain unclear. Using Rev-erbα +/-
Lejia Qiu +16 more
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BNIP3 is a key driver of breast cancer progression and a novel glycolysis-regulating biomarker [PDF]
Scientific ReportsBreast cancer (BC) represents a leading cause of cancer-related mortality among women, with glycolysis and immunomodulation playing pivotal roles in its progression. This study, by integrating bioinformatics analyses and in vitro and in vivo experiments,
Lichen Cao +5 more
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Autophagy/ Apoptosis Induced by Geraniol through HIF-1α/BNIP3/Beclin-1 Signaling Pathway in A549 CoCl2 Treated Cells [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose: During cancer growth, hypoxia occurs along with autophagy as an adaptive responseto overcome cellular stress. Geraniol (GE) is a natural isoprenoid known for its wide anticanceractivity and autophagy induction in the cancer cell.
Dina M. Abo El-Ella
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Overexpression of BNIP3 in rat intervertebral disk cells triggers autophagy and apoptosis [PDF]
Archives of Biological Sciences, 2022 Excessive apoptosis of intervertebral disk cells and intervertebral disk degeneration (IDD) is the prime cause of low back pain. B-cell lymphoma 2 (Bcl-2) and adenovirus E1B 19 kDa interacting protein 3 (BNIP3), a member of the Bcl-2 family, are involved
Tingsheng Wu +5 more
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The BH3 only Bcl-2 family member BNIP3 regulates cellular proliferation. [PDF]
PLoS ONE, 2018 The BH3-only family member BNIP3 has been described as either promoting cell survival or cell death. This depends upon the level of BNIP3 expression and its cellular localization. Increased BNIP3 expression under hypoxia contributes to cell death through
Amandeep Singh +6 more
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The proapoptotic protein BNIP3 interacts with VDAC to induce mitochondrial release of endonuclease G. [PDF]
PLoS ONE, 2014 BNIP3 is a proapoptotic protein that induces cell death through a mitochondria-mediated pathway. We reported previously that mitochondrial localization of BNIP3 and translocation of EndoG from mitochondria to the nucleus are critical steps of the BNIP3 ...
Xiaosha Zhang, Xiuwu Bian, Jiming Kong
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HIF1a-dependent mitophagy facilitates cardiomyoblast differentiation
Cell Stress, 2020 Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process.
Jin-Feng Zhao +4 more
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Tumor suppressor functions of BNIP3 and mitophagy [PDF]
Autophagy, 2015 There is a growing realization that tumor cells rely on healthy mitochondria to promote their growth under changing microenvironmental stresses and do so by dynamically modulating both their mitochondrial mass and state of mitochondrial fusion. Our recent work adds to this appreciation by showing that the mitophagy receptor BNIP3 functions as a tumor ...
Aparajita H, Chourasia, Kay F, Macleod
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