Results 21 to 30 of about 12,383 (188)
Cell Death and Disease, 2022 Embryonic stem cells (ESCs) have a significantly lower mutation load compared to somatic cells, but the mechanisms that guard genomic integrity in ESCs remain largely unknown.
Qian Zhao +9 more
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BNIP3 expression in follicular lymphoma
Histopathology, 2007 Aims: To investigate the role of BNIP3, a 19‐kDa interacting protein of the Bcl‐2 family, alongside Bcl‐2 in follicular lymphoma in comparison with reactive lymphoid hyperplasia. The results were compared with those from p53 and caspase‐3 (apoptotic markers) and Ki67 (proliferation marker).Methods and results: Immunohistochemistry using monoclonal ...
Sington, J +5 more
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Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog [PDF]
Oncogene, 1998 We have identified a C. elegans protein, ceBNIP3, homologous to the human BCL-2/EIB-19K interacting BCL-2 family pro-apoptotic protein BNIP3. In transiently transfected mammalian cells, ceBNIP3 complexes with CED-9, the worm homolog of BCL-2. CeBNIP3 also efficiently heterodimerizes with the cell death protease proCED-3 by direct binding via the ...
M, Yasuda +3 more
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Deficit of female sex hormones desensitizes rat cardiac mitophagy
Chinese Journal of Physiology, 2021 Long-term deprivation of female sex hormones has been shown to mediate accumulation of damaged mitochondria in ventricular muscle leading to cardiovascular dysfunction.
Theerachat Kampaengsri +3 more
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Autophagy and BNIP3 protein in tumorogenesis
Postępy Higieny i Medycyny Doświadczalnej, 2013 Autophagy is a process necessary for maintaining cell homeostasis in physiological conditions, as well as during certain stresses like nutrients or oxygen deprivation. Autophagy also plays an essential role in tumorigenesis. It prevents cell transformation, but on the other hand, autophagy enables existing cancer cells to adapt to harmful conditions ...
Ewelina, Swiderek, Leon, Strządała
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Role of BNIP3 in TNF-induced cell death — TNF upregulates BNIP3 expression
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009 Tumor necrosis factor alpha (TNF) is a cytokine that induces caspase-dependent (apoptotic) and caspase-independent (necrosis-like) cell death in different cells. We used the murine fibrosarcoma cell line model L929 and a stable L929 transfectant over-expressing a mutated dominant-negative form of BNIP3 lacking the C-terminal transmembrane (TM) domain ...
Ghavami, Saeid +9 more
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Regulation of BNIP3 in Normal and Cancer Cells
Molecules and Cells, 2006 Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) is a mitochondrial pro-apoptotic protein that has a single Bcl-2 homology 3 (BH3) domain and a COOH-terminal transmembrane (TM) domain. Al-though it belongs to the Bcl-2 family and can hetero-dimerize with Bcl-2, its pro-apoptotic activity is distinct from those of other members of the Bcl-2 ...
Hayyoung, Lee, Sang-Gi, Paik
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The effect of 4 weeks of continuous aerobic training with different volumes and starvation on the expression of some genes involved in liver mitophagy in healthy male Wistar rats [PDF]
ورزش و علوم زیست حرکتیIntroduction and Purpose: An increase in the number of defective mitochondria and their persistence can lead to apoptosis and necrosis of cells. Regular physical exercise along with time-restricted eating (TRE) can play an important role in improving ...
Hamzeh Bayani +3 more
doaj +1 more source
BNIP3 contributes to cisplatin‐induced apoptosis in ovarian cancer cells
FEBS Open Bio, 2020 BNIP3 is a proapoptotic protein that mediates apoptosis, necrosis and autophagy. However, the involvement of BNIP3 in cisplatin‐induced apoptosis in ovarian cancer is not clear.
Jinghui Jia +6 more
doaj +1 more source
A crosstalk between phosphorylation and ubiquitination of BNIP3 regulates mitophagy under hypoxia
Autophagy Reports, 2023 BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting protein 3) is a mitochondrial outer membrane protein that is sensitive to hypoxia and mediates mitophagy, a process important for mitochondrial quality control and to maintain energetic and redox ...
Yun-Ling He +4 more
doaj +1 more source