Results 21 to 30 of about 13,811 (214)
Bnip3 Binds and Activates p300: Possible Role in Cardiac Transcription and Myocyte Morphology.
PLoS ONE, 2015 Bnip3 is a hypoxia-regulated member of the Bcl-2 family of proteins that is implicated in apoptosis, programmed necrosis, autophagy and mitophagy. Mitochondria are thought to be the primary targets of Bnip3 although its activities may extend to the ER ...
John W Thompson +7 more
doaj +2 more sources
Akebia saponin D alleviates hepatic steatosis through BNip3 induced mitophagy
Journal of Pharmacological Sciences, 2018 Akebia Saponin D (ASD) is the most abundant constituent of the rhizome of Dipsacus asper Wall. The prior studies have shown that ASD alleviates hepatic steatosis targeted at the modulation of autophagy and exerts hepatoprotective effects through ...
Li-li Gong +9 more
doaj +2 more sources
Functional Dissection of BH3 Only Protein BNIP3
Functional Dissection of BH3 Only Protein BNIP3BNIP3 is a pro-apoptotic protein, which contains BH3 and trans-membrane domains. Previous studies demonstrated an association between ceBNIP3, C. elegans homologue of BNIP3, and ced-3.
Kawasaki, Takao +5 more
core +1 more source
, 2021 Mitophagy formed the basis of the original description of autophagy by Christian de Duve when he demonstrated that GCG (glucagon) induced macroautophagic/autophagic turnover of mitochondria in the liver.
Althea Bock-Hughes (10110719) +10 more
core +1 more source
BNIP3 phosphorylation by JNK1/2 promotes mitophagy via enhancing its stability under hypoxia
Cell Death and Disease, 2022 Mitophagy is an important metabolic mechanism that modulates mitochondrial quality and quantity by selectively removing damaged or unwanted mitochondria.
Yun-Ling He +11 more
doaj +1 more source
DNA methylation of the promoter region of bnip3 and bnip3l genes induced by metabolic programming
BMC Genomics, 2018 Background Environmental changes of biotic or abiotic nature during critical periods of early development may exert a profound influence on physiological functions later in life.
Vincent Veron +7 more
doaj +1 more source
BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria. [PDF]
PLoS ONE, 2012 Mieap, a p53-inducible protein, controls mitochondrial quality by repairing unhealthy mitochondria. During repair, Mieap induces the accumulation of intramitochondrial lysosomal proteins (designated MALM for Mieap-induced accumulation of lysosome-like ...
Yasuyuki Nakamura +7 more
doaj +1 more source
Hematology, 2023 Background: BCL2-interacting protein 3 (BNIP3) expression varies among cancers, and its role in myeloma cells remains unknown. We investigated the role of BNIP3 overexpression in myeloma cells, and particularly its effects on apoptosis and mitochondria ...
Pingping Xiao +7 more
doaj +1 more source
Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog [PDF]
Oncogene, 1998 We have identified a C. elegans protein, ceBNIP3, homologous to the human BCL-2/EIB-19K interacting BCL-2 family pro-apoptotic protein BNIP3. In transiently transfected mammalian cells, ceBNIP3 complexes with CED-9, the worm homolog of BCL-2. CeBNIP3 also efficiently heterodimerizes with the cell death protease proCED-3 by direct binding via the ...
M, Yasuda +3 more
openaire +2 more sources
Cells, 2022 Previous work showed a role of BNIP3 in myocardial remodeling and progression to HFrEF. We utilized a multiomics approach to unravel BNIP3-related molecular mechanisms in the pathogenesis of HFrEF.
Antoine H. Chaanine +5 more
doaj +1 more source