Results 41 to 50 of about 19,441 (231)

DNA methylation of the promoter region of bnip3 and bnip3l genes induced by metabolic programming

BMC Genomics, 2018
Background Environmental changes of biotic or abiotic nature during critical periods of early development may exert a profound influence on physiological functions later in life.
Vincent Veron, Lucie Marandel, Jingwei Liu, Emilio J. Vélez, Olivier Lepais, Stéphane Panserat, Sandrine Skiba, Iban Seiliez   +7 more
doaj   +1 more source

BNIP3-dependent mitophagy safeguards ESC genomic integrity via preventing oxidative stress-induced DNA damage and protecting homologous recombination

Cell Death and Disease, 2022
Embryonic stem cells (ESCs) have a significantly lower mutation load compared to somatic cells, but the mechanisms that guard genomic integrity in ESCs remain largely unknown.
Qian Zhao, Kun Liu, Lin Zhang, Zheng Li, Liang Wang, Jiani Cao, Youqing Xu, Aihua Zheng, Quan Chen, Tongbiao Zhao   +9 more
doaj   +1 more source

Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin [PDF]

, 2017
International audienceThe human pathogen Legionella pneumophila must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, L.
Abraham, Gilu, Dorn, Gerald W, II, Flavell, Richard A, Han, Qingqing, Hunot, Stephane, Masters, Seth L, Naderer, Thomas, Seidi, Azadeh, Speir, Mary, Vince, James E, Vogrin, Adam   +10 more
core   +4 more sources

BNIP3 expression in follicular lymphoma

Histopathology, 2007
Aims:  To investigate the role of BNIP3, a 19‐kDa interacting protein of the Bcl‐2 family, alongside Bcl‐2 in follicular lymphoma in comparison with reactive lymphoid hyperplasia. The results were compared with those from p53 and caspase‐3 (apoptotic markers) and Ki67 (proliferation marker).Methods and results:  Immunohistochemistry using monoclonal ...
Sington, J, Giatromanolaki, A, Campo, L, Turley, H, Pezzella, F, Gatter, K   +5 more
openaire   +2 more sources

Deficit of female sex hormones desensitizes rat cardiac mitophagy

Chinese Journal of Physiology, 2021
Long-term deprivation of female sex hormones has been shown to mediate accumulation of damaged mitochondria in ventricular muscle leading to cardiovascular dysfunction.
Theerachat Kampaengsri, Marisa Ponpuak, Jonggonnee Wattanapermpool, Tepmanas Bupha-Intr   +3 more
doaj   +1 more source

Myocardial Dysfunction in an Animal Model of Cancer Cachexia [PDF]

, 2011
Aims Fatigue is a common occurrence in cancer patients regardless of tumor type or anti-tumor therapies and is an especially problematic symptom in persons with incurable tumor disease.
Crawford, Danielle, Hutchinson, Kirk R., Lucchesi, Pamela A., McCarthy, Donna O., Velten, Markus, Wold, Loren E., Xu, Hui, Youtz, Dane J.   +7 more
core   +2 more sources

Autophagy and BNIP3 protein in tumorogenesis

Postępy Higieny i Medycyny Doświadczalnej, 2013
Autophagy is a process necessary for maintaining cell homeostasis in physiological conditions, as well as during certain stresses like nutrients or oxygen deprivation. Autophagy also plays an essential role in tumorigenesis. It prevents cell transformation, but on the other hand, autophagy enables existing cancer cells to adapt to harmful conditions ...
Ewelina, Swiderek, Leon, Strządała
openaire   +2 more sources

Role of BNIP3 in TNF-induced cell death — TNF upregulates BNIP3 expression

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
Tumor necrosis factor alpha (TNF) is a cytokine that induces caspase-dependent (apoptotic) and caspase-independent (necrosis-like) cell death in different cells. We used the murine fibrosarcoma cell line model L929 and a stable L929 transfectant over-expressing a mutated dominant-negative form of BNIP3 lacking the C-terminal transmembrane (TM) domain ...
Ghavami, Saeid, Eshraghi, Mehdi, Kadkhoda, Kamran, Mutawe, Mark M., Maddika, Subbareddy, Bay, Graham H., Wesselborg, Sebastian, Halayko, Andrew J., Klonisch, Thomas, Los, Marek Jan   +9 more
openaire   +3 more sources

Challenges of drug resistance in the management of pancreatic cancer [PDF]

, 2010
The current treatment of choice for metastatic pancreatic cancer involves single agent gemcitabine or combination of gemcitabine with capecitabine and erlotinib (tyrosine kinase inhibitor).
Akada, Allison, Almoguera, Andreetta, Arai, Arlt, Arteaga, Arumugam, Asano, Bachem, Baldwin, Banerjee, Bartsch, Bergers, Best, Bold, Bondar, Buck, Burris, Chakravarti, Chakravarti, Choi, Cunningham, Cunningham, Dancer, Dong, Duxbury, Duxbury, Duxbury, Duxbury, Engelman, Feldmann, Ferrero, Galmarini, Geyer, Giovannetti, Goan, Greer, Hagmann, Hahn, Henke, Hruban, Humeniuk, Ischenko, Ishikawa, Itoi, Jansen, Karapetis, Kindler, Kong, Koopman, Kulik, Lei, Lemoine, Liau, Liau, Longley, Mackey, Mackey, Mackey, Mahon, Mamaghani, Marechal, Marmor, Martin Clynes, Mata, Maxwell, Mendelsohn, Meropol, Miwa, Moertel, Molina-Arcas, Moore, Morgillo, Moriyama, Muerkoster, Muerkoster, Nakahira, Nakajima, Nakano, Naomi Walsh, Nishimura, Oguri, Okamoto, Okumura, Olive, O’Driscoll, Pao, Park, Park, Peters, Plunkett, Ray McDermott, Ritzel, Rizwan Sheikh, Robert O’Connor, Ruggeri, Safran, Saito, Sakamoto, Schuller, Sebastiani, Shah, Shi, Simon, Spratlin, Takao, Takebayashi, Treat, Tsukamoto, Tzeng, Vaishampayan, Van Cutsem, van der Wilt, Wang, Wang, Wang, Xiong, Yamasaki, Yokoi   +119 more
core   +1 more source

Regulation of BNIP3 in Normal and Cancer Cells

Molecules and Cells, 2006
Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) is a mitochondrial pro-apoptotic protein that has a single Bcl-2 homology 3 (BH3) domain and a COOH-terminal transmembrane (TM) domain. Al-though it belongs to the Bcl-2 family and can hetero-dimerize with Bcl-2, its pro-apoptotic activity is distinct from those of other members of the Bcl-2 ...
Hayyoung, Lee, Sang-Gi, Paik
openaire   +2 more sources