Results 61 to 70 of about 13,811 (214)
Advanced Science, EarlyView.RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao +14 more
wiley +1 more source
The BNIP3 C-terminus can be phosphorylated.
, 2015 (A) Western blot detection of immunoprecipitated BNIP3 using an α-PKA substrate antibody specific to the phosphorylated RRXS/T sequence, located at the BNIP3 C-terminus and adjacent to the transmembrane (TM) domain.
William A. Frazier (759144) +1 more
core +1 more source
Cellular & Molecular Biology Letters, 2021 Background Manganese overexposure can induce neurotoxicity, lead to manganism and result in clinical manifestations similar to those of parkinsonism. However, the underlying molecular mechanism is still unclear. This study demonstrated that MnCl2 induces
Yanning Huang +6 more
doaj +1 more source
Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice
Advanced Science, EarlyView.Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li +5 more
wiley +1 more source
BNIP3 is required for the differentiation of monocyte to macrophage
The FASEB Journal, 2006 The molecular mechanism of all‐ trans retinoic acid (ATRA)‐induced differentiation was under investigation. A pro‐apoptotic protein BNIP3 (Bcl‐2/adenovirus E1B 19 kda‐interacting protein 3) was thus identified by hybridization of human cDNA microarrays with cDNA derived from ATRA‐treated ...
Ching Li +3 more
openaire +1 more source
Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration
Advanced Science, EarlyView.This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya +10 more
wiley +1 more source
Bnip3 increases p300 acetyltransferase activity.
, 2015 Histone deacetylase (HDAC) (A) and acetyltransferase (HAT) (B) activities were measured in cardiac myocytes exposed to aerobic, hypoxia (HX) and hypoxia-acidosis (HA) as described in Methods. P300-specific acetyltransferase activity is shown in (C).
Huilan Wang (789663) +7 more
core +1 more source
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
Functional Dissection of BH3 Only Protein BNIP3
, 2001 BNIP3 is a pro-apoptotic protein, which contains BH3 and trans-membrane domains. Previous studies demonstrated an association between ceBNIP3, C. elegans homologue of BNIP3, and ced-3.
Kawasaki, Takao +5 more
core +1 more source
BNip3 Regulates Mitochondrial Function and Lipid Metabolism in the Liver [PDF]
Molecular and Cellular Biology, 2012 BNip3 localizes to the outer mitochondrial membrane, where it functions in mitophagy and mitochondrial dynamics. While the BNip3 protein is constitutively expressed in adult liver from fed mice, we have shown that its expression is superinduced by fasting of mice, consistent with a role in responses to nutrient deprivation.
Glick, Danielle +9 more
openaire +3 more sources