Results 61 to 70 of about 19,441 (231)
BNIP3 promotes calcium and calpain-dependent cell death [PDF]
Life Sciences, 2015 Loss of cardiac muscle by programmed cell death contributes to the progression of ischemic heart disease. Hypoxia, metabolite waste buildup and energy depletion are components of ischemia which may initiate caspase dependent and independent cell death pathways.
Regina M, Graham +2 more
openaire +2 more sources
Regulation of Mitochondrial Integrity, Autophagy and Cell Survival by BNIP3 [PDF]
Autophagy, 2007 Understanding the role of BNIP3 in the systemic response to hypoxia has been complicated by conflicting results that indicate on the one hand that BNIP3 promotes cell death, and other data, including our own that BNIP3 is not sufficient for cell death, but rather plays a critical role in hypoxia-induced autophagy.
Kristin, Tracy, Kay F, Macleod
openaire +2 more sources
BNIP3 Upregulation Characterizes Cancer Cell Subpopulation With Increased Fitness and Proliferation
Frontiers in Oncology, 2022 BNIP3 is a BH3-only protein with both pro-apoptotic and pro-survival roles depending on the cellular context. It remains unclear how BNIP3 RNA level dictates cell fate decisions of cancer cells.
Yanyan Zhu +9 more
doaj +1 more source
The Aging Heart: Mitophagy at the Center of Rejuvenation. [PDF]
, 2020 Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging at the cellular and molecular ...
Gustafsson, Åsa B, Liang, Wenjing J
core +1 more source
Mitophagy and the therapeutic clearance of damaged mitochondria for neuroprotection [PDF]
, 2016 Mitochondria are the foremost producers of the cellular energy currency ATP. They are also a significant source of reactive oxygen species and an important buffer of intracellular calcium.
Bingol +66 more
core +2 more sources
Hypoxia helps glioma to fight therapy [PDF]
, 2009 Despite major improvements in the surgical management the prognosis for patients bearing malignant gliomas is still dismal. Malignant gliomas are notoriously resistant to treatment and the survival time of patients is between 3-8 years for low-grade and
Amberger-Murphy, Verena
core +1 more source
Cloning of BNIP3h, a member of proapoptotic BNIP3 family genes [PDF]
Experimental & Molecular Medicine, 2001 Apoptosis is regulated by interaction of antiapoptotic Bcl-2 family proteins with various proapoptotic proteins, several of which are also members of the Bcl-2 family. BNIP3 (formerly NIP3) is a proapoptotic mitochondrial protein classified in the Bcl-2 family based on limited sequence homology-3 (BH3) domain and COOH-terminal transmembrane domain ...
M, Farooq +7 more
openaire +2 more sources
Cezanne regulates E2F1-dependent HIF2α expression [PDF]
, 2015 Mechanisms regulating protein degradation ensure the correct and timely expression of transcription factors such as hypoxia inducible factor (HIF).
Altun +48 more
core +4 more sources
Bnip3-mediated defects in oxidative phosphorylation promote mitophagy [PDF]
Autophagy, 2011 The Bcl-2 proteins are best known as regulators of the intrinsic mitochondrial pathway of apoptosis. However, recent studies have demonstrated that they can also regulate autophagy. For many years, autophagy was considered to be a nonselective process where the autophagosomes randomly sequestered contents in the cytosol to supply the cells with amino ...
Robert L, Thomas +2 more
openaire +2 more sources
Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. [PDF]
, 2013 Cellular stress responses are frequently governed by the subcellular localization of critical effector proteins. Apoptosis-inducing Factor (AIF) or Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH), for example, can translocate from mitochondria to the ...
Aghi, Manish +14 more
core +2 more sources