Results 1 to 10 of about 87,570 (230)

Increased HIF-1α expression in T cells and associated with enhanced Th17 pathway in systemic lupus erythematosus

Journal of the Formosan Medical Association, 2022
Background/Purpose: Recent emerging evidence indicates that dysfunction of metabolic remodeling underlies aberrant T cell immune responses in systemic lupus erythematosus (SLE).
Hsiu-Jung Liao, Ching-Liang Chu, Szu-Chieh Wang, Hua-Yi Lee, Chien-Sheng Wu   +4 more
doaj   +1 more source

HIF-1α contributes to Ang II-induced inflammatory cytokine production in podocytes

BMC Pharmacology and Toxicology, 2019
Background Studies have indicated that changed expression of hypoxia-inducible factor-1α (HIF-1α) in epithelial cells from the kidney could affect the renal function in chronic kidney disease (CKD).
Hao Huang, Yanqin Fan, Zhao Gao, Wei Wang, Ning Shao, Lu Zhang, Yingjie Yang, Weifang Zhu, Zhaowei Chen, Jijia Hu, Guohua Ding   +10 more
doaj   +1 more source

Mechanism of HIF-1α Promoting Malignant Development of Nasopharyngeal Carcinoma by Upregulating PD-L1 Under Hypoxic Conditions

Zhongliu Fangzhi Yanjiu, 2021
Objective To explore the mechanism of HIF-1α promoting malignant development of nasopharyngeal carcinoma by upregulating PD-L1 expression under hypoxic conditions.
JIANG Doudou, DONG Jiawen, HU Desheng, ZHOU Yajuan   +3 more
doaj   +1 more source

ILKAP Binding to and Dephosphorylating HIF-1α is Essential for Apoptosis Induced by Severe Hypoxia

Cellular Physiology and Biochemistry, 2018
Background/Aims: Integrin-linked kinase-associated phosphatase (ILKAP), a serine/threonine phosphatase that belongs to the protein phosphatase 2C family, has a role in cell survival and apoptosis.
Tielong Liu, Yonggang Liu, Jiashi Cao, Xin Gao, Jing Wang, Guanghui Chen, Yang Wang, Ge Liu, Guangjian Bai, Yiwei Hu, Jiaxiang Yang, Lianfeng Dong, Xinbao Quan, Weiwei Zou   +13 more
doaj   +1 more source

HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer. [PDF]

PLoS ONE, 2015
It is well recognized that hypoxia-inducible factor 1 alpha (HIF-1α) is involved in cancer metastasis, chemotherapy and poor prognosis. We previously found that deferoxamine, a hypoxia-mimetic agent, induces epithelial-mesenchymal transition (EMT) in ...
Wenjing Zhang, Xinpeng Shi, Ying Peng, Meiyan Wu, Pei Zhang, Ruyi Xie, Yao Wu, Qingqing Yan, Side Liu, Jide Wang   +9 more
doaj   +1 more source

Hypoxia-inducible factor-1α as a biomarker for individuals under hypoxia duration and pattern in fat greenling Hexagrammos otakii

Aquaculture Reports
Background: One common environmental stressor in fisheries is hypoxia stress, which frequently causes significant fish mortality and financial losses. This study aimed to examine the potential utility of serum concentrations of hypoxia-inducible factor ...
Yu Zhan, Xin Qi, Yiting Wu, Dongxu Gao, Ling Zhao, Shengnan Cao, Zhuang Xue, Wei Wang   +7 more
doaj   +1 more source

Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease

Molecular Neurodegeneration, 2010
Background Mutations in presenilin-1 (Psen1) cause familial Alzheimer's disease (FAD). Both hypoxia and ischemia have been implicated in the pathological cascade that leads to amyloid deposition in AD.
Sosa Miguel, De Gasperi Rita, Dracheva Stella, Elder Gregory A   +3 more
doaj   +1 more source

A regulatory feedback loop between HIF-1α and PIM2 in HepG2 cells. [PDF]

PLoS ONE, 2014
To survive under hypoxic conditions, cancer cells remodel glucose metabolism to support tumor progression. HIF transcription factor is essential for cellular response to hypoxia.
Zhenhai Yu, Xiaoping Zhao, Yingying Ge, Teng Zhang, Liangqian Huang, Xiang Zhou, Lei Xie, Jianjun Liu, Gang Huang   +8 more
doaj   +1 more source

Age-Related Expression and Localization of HIF-1α and HIF-2α in Different Tissues of Yak

Oxygen
The yak (Bos grunniens), a unique bovine species that is endemic to the Qinghai–Tibet Plateau and adjacent mountainous regions, exhibits remarkable adaptations to chronic high-altitude hypoxia.
Qin Wu, Huan Yang, Junyu Chen, Zhixin Chai, Hongwen Zhao, Zhijuan Wu   +5 more
doaj   +1 more source

Hypoxia-inducible factor 1 alpha expression increases during colorectal carcinogenesis and tumor progression

BMC Cancer, 2008
Background Hypoxia-inducible factor 1 alpha (HIF-1α) is involved in processes promoting carcinogenesis of many tumors. However, its role in the development of colorectal cancer is unknown.
Jayasinghe Caren, Taxeidis Marios, Simiantonaki Nektaria, Kurzik-Dumke Ursula, Kirkpatrick Charles   +4 more
doaj   +1 more source