Results 31 to 40 of about 136,040 (279)

Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo.

PLoS ONE, 2010
BackgroundHypoxia inducible factor-1α (HIF-1α) is responsible for the majority of HIF-1-induced gene expression changes under hypoxia and for the "angiogenic switch" during tumor progression.
Lavinia Nardinocchi, Valentina Pantisano, Rosa Puca, Manuela Porru, Aurora Aiello, Annalisa Grasselli, Carlo Leonetti, Michal Safran, Gideon Rechavi, David Givol, Antonella Farsetti, Gabriella D'Orazi   +11 more
doaj   +1 more source

Prognostic stratification based on HIF-1α signaling for evaluating hypoxia status and immune landscape in hepatocellular carcinoma

Journal of Big Data, 2023
Hepatocellular carcinoma (HCC) has a desmoplastic and hypoxic tumor microenvironment (TME), resulting in poor prognosis and treatment resistance. This study aimed to construct a novel prognostic classifier to investigate the degree of hypoxia and immune ...
Hongkai Zhuang, Zedan Zhang, Bo Chen, Chenwei Tang, Xinming Chen, Wenliang Tan, Lei Yang, Zhiqin Xie, Xiaowu Ma, Qingbin Wang, Bingkun Wang, Changzhen Shang, Yajin Chen   +12 more
doaj   +1 more source

hZIP1 Inhibits Progression of Clear Cell Renal Cell Carcinoma by Suppressing NF-kB/HIF-1α Pathway

Frontiers in Oncology, 2021
PurposeAccumulating literature has suggested that hZIP1 and HIF-1α play vital roles in the tumor process of clear cell renal cell carcinoma (ccRCC). However, the functional roles of hZIP1 and HIF-1α in ccRCC remain largely unknown.MethodsHIF-1α protein ...
Bo Zhan, Xiao Dong, Yulin Yuan, Zheng Gong, Bohan Li   +4 more
doaj   +1 more source

Emerging Roles Of hsa-circ-0046600 Targeting The miR-640/HIF-1α Signalling Pathway In The Progression Of HCC.

OncoTargets and therapy, 2019
Circular RNAs (circRNAs) play important roles in the development and progression of various human cancers. hsa-circ-0046600 is a circRNA of unknown function. The purpose of this study was to investigate the biological function of hsa-circ-0046600 in hepatocellular carcinoma (HCC) and elucidate the possible molecular mechanisms of this circRNA.GSE97332,
Zhai,Zhensheng, Fu,Qiang, Liu,Chuanjiang, Zhang,Xu, Jia,Pengchong, Xia,Peng, Liu,Pan, Liao,Shixiu, Qin,Tao, Zhang,Hongwei   +9 more
openaire   +3 more sources

Responses to hypoxia via mTOR : role in endothelial cell proliferation and HIF-1[alpha] stabilization [PDF]

, 2005
Ischemic cardiovascular disease and cancer are life-threatening disorders in human mortality. Intensive studies on the etiology of and therapeutics for the diseases are ongoing.
Li, Weimin
core   +1 more source

Hypoxia inducible factor-1α is an important regulator of macrophage biology

Heliyon, 2023
Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor composed of the α and β subunits, regulates cellular adaptive responses to hypoxia. Macrophages, which are derived from monocytes, function as antigen-presenting cells that activate
Bingquan Qiu, Piaoliu Yuan, Xiaojuan Du, Hongfang Jin, Junbao Du, Yaqian Huang   +5 more
doaj   +1 more source

A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization [PDF]

, 2007
Background Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of ...
Green Dixy E, Ihnat Michael A, Green, Dixy E., Satyendra S Shenoy, Shenoy Satyendra S, Green DE, Thorpe JE, Ceriello Antonio, Kamat CD, Ceriello, Antonio, Antonio Ceriello, Shenoy, Satyendra S, Dixy E Green, Kamat Chandrashekhar D, Linda A Warnke, Warnke, Linda A., Warnke Linda A, Shenoy SS, Chandrashekhar D Kamat, Michael A Ihnat, Warnke LA, Kamat, Chandrashekhar D., Ihnat, Michael A., Ihnat M.A., Thorpe, Jessica E, Thorpe Jessica E, Jessica E Thorpe   +26 more
core   +1 more source

PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia [PDF]

, 2014
A17 Hypoxia is an important developmental cue for multicellular organisms but it is also a contributing factor for several human pathologies, such as stroke, cardiovascular diseases and cancer.
Michael Batie (681257), Mudie, Sharon, Moniz, Sonia, Sonia Rocha (231588), Sonia Moniz (681259), Ortmann, Brian, Brian Ortmann (681260), Daniel Bandarra (681256), Sharon Mudie (231581), Batie, Michael, Biddlestone, John, Alena Shmakova (681261), Shmakova, Alena, Bandarra, Daniel, John Biddlestone (681258), Rocha, Sonia   +15 more
core   +1 more source

Down‐regulation of TIMP2 by HIF‐1α/miR‐210/HIF‐3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma

Hepatology, 2016
Cancer metastasis is a multistep process that involves a series of tumor‐stromal interaction, including extracellular matrix (ECM) remodeling, which requires a concerted action of multiple proteolytic enzymes and their endogenous inhibitors. This study investigated the role of tissue inhibitor of metalloproteinases (TIMP) 2 in the context of ...
Chan, Lo Kong, Lo, Regina Cheuk Lam, Lee, Joyce Man Fong, Wong, Carmen Chak Lui, Wong, Jack Chun Ming, Ng, Irene Oi Lin, Kai, Alan Ka Lun   +6 more
openaire   +5 more sources

Therapeutic potential of topical administration of siRNAs against HIF-1α for corneal neovascularization

, 2022
Given the implications of the problem of neovascularization on ocular health, as well as the growth in the number of cases, the purpose of the present study has been testing the efficacy of siRNAs (small interfering RNA) designed to silence Hypoxia ...
Mateo Ibáñez, Jesús, Domínguez Godínez, Carmen Olalla, Carracedo Rodríguez, Juan Gonzalo, Gómez Pedrero, José Antonio, Crooke Álvarez, Almudena, Peral Cerda, María Asunción, Pintor Just, Jesús Jerónimo   +6 more
core   +1 more source