Results 31 to 40 of about 84,588 (227)

PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α

Genes and Diseases
Pyruvate dehydrogenase kinase 1 (PDK1) phosphorylates the pyruvate dehydrogenase complex, which inhibits its activity. Inhibiting pyruvate dehydrogenase complex inhibits the tricarboxylic acid cycle and the reprogramming of tumor cell metabolism to ...
Yu Wei, Dian Zhang, He Shi, Husun Qian, Hongling Chen, Qian Zeng, Fangfang Jin, Yan Ye, Zuli Ou, Minkang Guo, Bianqin Guo, Tingmei Chen   +11 more
doaj   +1 more source

Expression significance and potential mechanism of hypoxia‐inducible factor 1 alpha in patients with myelodysplastic syndromes

Cancer Medicine, 2019
Objective To investigate the expression level and potential mechanism of hypoxia‐inducible factor 1 alpha (HIF‐1α) in patients with myelodysplastic syndromes (MDS). Methods Immunohistochemistry (IHC) techniques were used to examine the protein expression
Hai‐wei Liang, Bin Luo, Li‐hua Du, Rong‐quan He, Gang Chen, Zhi‐gang Peng, Jie Ma   +6 more
doaj   +1 more source

No Amplifications of Hypoxia-Inducible Factor-1α Gene in Invasive Breast Cancer: A Tissue Microarray Study

Cellular Oncology, 2004
Objective: Hypoxia Inducible Factor‐1 (HIF‐1) is an important transcription factor that stimulates tumour growth and metastases via several pathways, including angiogenesis and altered metabolism.
Marije M. Vleugel, Reinhard Bos, Horst Buerger, Petra van der Groep, Outi R. Saramäki, Tapio Visakorpi, Elsken van der Wall, Paul J. van Diest   +7 more
doaj   +1 more source

Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes

Journal of Neuroinflammation, 2007
Background Neuroinflammation has been implicated in various brain pathologies characterized by hypoxia and ischemia. Astroglia play an important role in the initiation and propagation of hypoxia/ischemia-induced inflammation by secreting inflammatory ...
Mojsilovic-Petrovic Jelena, Callaghan Debbie, Cui Hong, Dean Clare, Stanimirovic Danica B, Zhang Wandong   +5 more
doaj   +1 more source

The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia

Journal of Hematology & Oncology, 2021
Hypoxia inducible factor-1α (HIF-1α) up-regulates the expression of programmed death ligand-1 (PD-L1) in some extracranial malignancies. However, whether it could increase PD-L1 expression in intracranial tumor is still unknown.
Xing-chen Ding, Liang-liang Wang, Xue-dong Zhang, Jun-long Xu, Pei-feng Li, Hua Liang, Xian-bin Zhang, Li Xie, Zi-han Zhou, Jia Yang, Ralph R. Weichselbaum, Jin-ming Yu, Man Hu   +12 more
doaj   +1 more source

14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer

Cell Reports, 2023
Summary: A hypoxic microenvironment contributes to tumor progression, with hypoxia-inducible factor-1α (HIF-1α) being a critical regulator. We have reported that 14-3-3σ is negatively associated with HIF-1α expression; however, its role in hypoxia ...
Sicheng Liu, Rui Guo, Hui Xu, Jinneng Yang, Haidan Luo, Sai-Ching Jim Yeung, Kai Li, Mong-Hong Lee, Runxiang Yang   +8 more
doaj   +1 more source

Long Non-Coding RNA CASC9 And HIF-1α Form A Positive Feedback Loop To Facilitate Cell Proliferation And Metastasis In Lung Cancer.

OncoTargets and therapy, 2019
The long noncoding RNA cancer susceptibility 9 (CASC9) has been recognized as an important modulator of cell growth and metastasis in many cancers. However, its detailed roles in lung cancer remain unclear. In this study, we aimed to investigate its functions and molecular mechanism in lung cancer progression.Expression of CASC9 was determined in lung ...
Jin,Yuxing, Xie,Huikang, Duan,Liang, Zhao,Deping, Ding,Jiaan, Jiang,Gening   +5 more
openaire   +3 more sources

HIF-1α Alleviates High-Glucose-Induced Renal Tubular Cell Injury by Promoting Parkin/PINK1-Mediated Mitophagy

Frontiers in Medicine, 2022
It is well-established that mitophagy leads to Diabetic Nephropathy (DN) and renal failure. Mitophagy mediated by a Hypoxia-inducible factor-1α (HIF-1α) plays a beneficial role in many diseases.
Lu Yu, Yulin Wang, Yan Hong Guo, Liuwei Wang, Zijun Yang, Zi Han Zhai, Lin Tang   +6 more
doaj   +1 more source

Non-electron transfer chain mitochondrial defects differently regulate HIF-1α degradation and transcription

Redox Biology, 2017
Mitochondria are the main consumers of molecular O2 in a cell as well as an abundant source of reactive oxygen species (ROS). Both, molecular oxygen and ROS are powerful regulators of the hypoxia-inducible factor-1α-subunit (HIF-α).
Antonina N. Shvetsova, Daniela Mennerich, Juha M. Kerätär, J. Kalervo Hiltunen, Thomas Kietzmann   +4 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source