Results 31 to 40 of about 151,161 (274)

Zinc downregulates HIF-1α and inhibits its activity in tumor cells in vitro and in vivo.

PLoS ONE, 2010
BackgroundHypoxia inducible factor-1α (HIF-1α) is responsible for the majority of HIF-1-induced gene expression changes under hypoxia and for the "angiogenic switch" during tumor progression.
Lavinia Nardinocchi, Valentina Pantisano, Rosa Puca, Manuela Porru, Aurora Aiello, Annalisa Grasselli, Carlo Leonetti, Michal Safran, Gideon Rechavi, David Givol, Antonella Farsetti, Gabriella D'Orazi   +11 more
doaj   +1 more source

A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization [PDF]

, 2007
Background Endothelial dysfunction (ED) is functionally characterized by decreased vasorelaxation, increased thrombosis, increased inflammation, and altered angiogenic potential, has been intimately associated with the progression and severity of ...
Green Dixy E, Ihnat Michael A, Green, Dixy E., Satyendra S Shenoy, Shenoy Satyendra S, Green DE, Thorpe JE, Ceriello Antonio, Kamat CD, Ceriello, Antonio, Antonio Ceriello, Shenoy, Satyendra S, Dixy E Green, Kamat Chandrashekhar D, Linda A Warnke, Warnke, Linda A., Warnke Linda A, Shenoy SS, Chandrashekhar D Kamat, Michael A Ihnat, Warnke LA, Kamat, Chandrashekhar D., Ihnat, Michael A., Ihnat M.A., Thorpe, Jessica E, Thorpe Jessica E, Jessica E Thorpe   +26 more
core   +2 more sources

Overexpression of Hypoxia-Inducible Factor-1α and Its Relation with Aggressiveness and Grade of Oral Squamous Cell Carcinoma

Diagnostics, 2023
Hypoxia-inducible factor-1α (HIF-1α) has been shown to be involved in cancer metastasis in several cancer types. There is however conflicting evidence of HIF-1α expression with oral cancer prognosis.
Sumera Sumera, Asif Ali, Yasar M. Yousafzai, Zubair Durrani, Mohammed Alorini, Benish Aleem, Rabia Zahir   +6 more
doaj   +1 more source

HIF-1α protects against oxidative stress by directly targeting mitochondria

Redox Biology, 2019
The transcription factor hypoxia inducible factor-1α (HIF-1α) mediates adaptive responses to oxidative stress by nuclear translocation and regulation of gene expression.
Hong-Sheng Li, Yan-Ni Zhou, Lu Li, Sheng-Fu Li, Dan Long, Xue-Lu Chen, Jia-Bi Zhang, Li Feng, You-Ping Li   +8 more
doaj   +1 more source

Down‐regulation of TIMP2 by HIF‐1α/miR‐210/HIF‐3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma

Hepatology, 2016
Cancer metastasis is a multistep process that involves a series of tumor‐stromal interaction, including extracellular matrix (ECM) remodeling, which requires a concerted action of multiple proteolytic enzymes and their endogenous inhibitors. This study investigated the role of tissue inhibitor of metalloproteinases (TIMP) 2 in the context of ...
Chan, Lo Kong, Lo, Regina Cheuk Lam, Lee, Joyce Man Fong, Wong, Carmen Chak Lui, Wong, Jack Chun Ming, Ng, Irene Oi Lin, Kai, Alan Ka Lun   +6 more
openaire   +5 more sources

Interaction between HIF-1α (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1α [PDF]

, 2005
Hypoxia inducible factor-1α (HIF-1α) is a central component of the cellular responses to hypoxia. Hypoxic conditions result in stabilization of HIF-1α and formation of the transcriptionally active HIF-1 complex.
Evjenth, Rune, Sang, Nianli, Caro, Jaime, Arnesen, Thomas, Gromyko, Darina, Varhaug, Jan Erik, Kong, Xianguo, Lin, Zhao, Lillehaug, Johan R.   +8 more
core   +1 more source

Silencing HIF-1α reduces the adhesion and secretion functions of acute leukemia hBMSCs

Brazilian Journal of Medical and Biological Research, 2012
Hypoxia inducible factor-1α (HIF-1α) is an important transcription factor, which plays a critical role in the formation of solid tumor and its microenviroment.
Zeng Dong-Feng, Liu Ting, Chang Cheng, Zhang Xi, Liang Xue, Chen Xing-Hua, Kong Pei-Yan   +6 more
doaj   +1 more source

HIF-1α expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis

World Journal of Surgical Oncology, 2020
Background The role of hypoxia-inducible factor-1α (HIF-1α) in primary colorectal cancer (CRC) and colorectal liver metastasis (CRLM) has remained unclear.
Yuma Wada, Yuji Morine, Satoru Imura, Tetsuya Ikemoto, Yu Saito, Chie Takasu, Shinichiro Yamada, Mitsuo Shimada   +7 more
doaj   +1 more source

Therapeutic potential of topical administration of siRNAs against HIF-1α for corneal neovascularization

, 2022
Given the implications of the problem of neovascularization on ocular health, as well as the growth in the number of cases, the purpose of the present study has been testing the efficacy of siRNAs (small interfering RNA) designed to silence Hypoxia ...
Mateo Ibáñez, Jesús, Domínguez Godínez, Carmen Olalla, Carracedo Rodríguez, Juan Gonzalo, Gómez Pedrero, José Antonio, Crooke Álvarez, Almudena, Peral Cerda, María Asunción, Pintor Just, Jesús Jerónimo   +6 more
core   +1 more source

PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α

Genes and Diseases
Pyruvate dehydrogenase kinase 1 (PDK1) phosphorylates the pyruvate dehydrogenase complex, which inhibits its activity. Inhibiting pyruvate dehydrogenase complex inhibits the tricarboxylic acid cycle and the reprogramming of tumor cell metabolism to ...
Yu Wei, Dian Zhang, He Shi, Husun Qian, Hongling Chen, Qian Zeng, Fangfang Jin, Yan Ye, Zuli Ou, Minkang Guo, Bianqin Guo, Tingmei Chen   +11 more
doaj   +1 more source