Results 51 to 60 of about 136,040 (279)

Long Non-Coding RNA CASC9 And HIF-1α Form A Positive Feedback Loop To Facilitate Cell Proliferation And Metastasis In Lung Cancer.

OncoTargets and therapy, 2019
The long noncoding RNA cancer susceptibility 9 (CASC9) has been recognized as an important modulator of cell growth and metastasis in many cancers. However, its detailed roles in lung cancer remain unclear. In this study, we aimed to investigate its functions and molecular mechanism in lung cancer progression.Expression of CASC9 was determined in lung ...
Jin,Yuxing, Xie,Huikang, Duan,Liang, Zhao,Deping, Ding,Jiaan, Jiang,Gening   +5 more
openaire   +3 more sources

Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis.

, 2011
BACKGROUND: Clear cell renal cell carcinoma (CCRCC) is the commonest form of kidney cancer. Up to 91% have biallelic inactivation of VHL, resulting in stabilisation of HIF-α subunits.
T Bhattacharyya, M A Esteban, S Kiriakidis, Kiriakidis, Serafim, Kiriakidis, S, P H Maxwell, Barod, R, M N Khan, Connor, T, Andrikopoulos, P, Bhattacharyya, T, Ashcroft, M, R Barod, T Connor, M Ashcroft, Khan, MN, Maxwell, PH, Esteban, MA, P Andrikopoulos   +18 more
core   +1 more source

HIF-1α Dependent Upregulation of ZIP8, ZIP14, and TRPA1 Modify Intracellular Zn2+ Accumulation in Inflammatory Synoviocytes

, 2021
Intracellular free zinc ([Zn2+]i) is mobilized in neuronal and non-neuronal cells under physiological and/or pathophysiological conditions; therefore, [Zn2+]i is a component of cellular signal transduction in biological systems.
Matsubara, Masaki, Hiroka Suzuki, Katsuhiko Muraki, Suzuki, Hiroka, Muraki, Katsuhiko, Yukiko Muraki, Masaki Matsubara, Muraki, Yukiko, Noriyuki Hatano, Hatano, Noriyuki   +9 more
core   +1 more source

The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia

Journal of Hematology & Oncology, 2021
Hypoxia inducible factor-1α (HIF-1α) up-regulates the expression of programmed death ligand-1 (PD-L1) in some extracranial malignancies. However, whether it could increase PD-L1 expression in intracranial tumor is still unknown.
Xing-chen Ding, Liang-liang Wang, Xue-dong Zhang, Jun-long Xu, Pei-feng Li, Hua Liang, Xian-bin Zhang, Li Xie, Zi-han Zhou, Jia Yang, Ralph R. Weichselbaum, Jin-ming Yu, Man Hu   +12 more
doaj   +1 more source

14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer

Cell Reports, 2023
Summary: A hypoxic microenvironment contributes to tumor progression, with hypoxia-inducible factor-1α (HIF-1α) being a critical regulator. We have reported that 14-3-3σ is negatively associated with HIF-1α expression; however, its role in hypoxia ...
Sicheng Liu, Rui Guo, Hui Xu, Jinneng Yang, Haidan Luo, Sai-Ching Jim Yeung, Kai Li, Mong-Hong Lee, Runxiang Yang   +8 more
doaj   +1 more source

HIF-1α immunohistochemistry (IHC) and immunoblot.

, 2019
Human breast cancer sample examples from the contralateral breast cancer cohort negative (A, B) and positive (C-F) for HIF-1α IHC. * marks a necrotic area with perinecrotic cells staining positive for HIF-1α.
Annika Jögi (132709), Anna Ehinger (2558494), Linda Hartman (813278), Sara Alkner (2558497)   +3 more
core   +1 more source

DataSheet_1_Lactate increases tumor malignancy by promoting tumor small extracellular vesicles production via the GPR81-cAMP-PKA-HIF-1α axis.docx

, 2022
Lactate and tumor cell-derived extracellular vesicles (TEVs) both contribute to tumor progression. However, it is still unclear whether lactate can accelerate tumor development by directly promoting TEV production.
Yuxiao Tong (14201876), Junqi Zhu (13918596), Man Luo (105740), Limin Wang (87511), Jie Ren (176083), Jiaoli Wang (740874), Shenglin Ma (499605)   +6 more
core   +1 more source

Non-electron transfer chain mitochondrial defects differently regulate HIF-1α degradation and transcription

Redox Biology, 2017
Mitochondria are the main consumers of molecular O2 in a cell as well as an abundant source of reactive oxygen species (ROS). Both, molecular oxygen and ROS are powerful regulators of the hypoxia-inducible factor-1α-subunit (HIF-α).
Antonina N. Shvetsova, Daniela Mennerich, Juha M. Kerätär, J. Kalervo Hiltunen, Thomas Kietzmann   +4 more
doaj   +1 more source

HIF-1α Alleviates High-Glucose-Induced Renal Tubular Cell Injury by Promoting Parkin/PINK1-Mediated Mitophagy

Frontiers in Medicine, 2022
It is well-established that mitophagy leads to Diabetic Nephropathy (DN) and renal failure. Mitophagy mediated by a Hypoxia-inducible factor-1α (HIF-1α) plays a beneficial role in many diseases.
Lu Yu, Yulin Wang, Yan Hong Guo, Liuwei Wang, Zijun Yang, Zi Han Zhai, Lin Tang   +6 more
doaj   +1 more source

HIF-1α forms a PARylated complex with PARP1.

, 2018
A) Following immunoprecipitation with IgG and PARP1 antibodies, western blot for HIF-1α confirms that PARP1 immunoprecipitates with HIF-1α to a greater extent in LMP1+ vs LMP1- cells and this is attenuated by 1 μM 72 hr olaparib treatment.
Yinfei Tan (5932118), Michael Hulse (5932112), Lisa B. Caruso (5932115), Sarah Johnson (248721), Italo Tempera (83276), Jozef Madzo (8296)   +5 more
core   +1 more source