Results 51 to 60 of about 151,161 (274)
HIF-1α immunohistochemistry (IHC) and immunoblot.
, 2019 Human breast cancer sample examples from the contralateral breast cancer cohort negative (A, B) and positive (C-F) for HIF-1α IHC. * marks a necrotic area with perinecrotic cells staining positive for HIF-1α.
Annika Jögi (132709) +3 more
core +1 more source
Effects of HIF-1α on ERRα/γ protein expression in mouse skeletal muscle [PDF]
, 2015 Aims: HIF-1α plays an important role in the adaptive responses to hypoxia. The ERRα and γ are crucial regulators of energy metabolism in skeletal muscle.
Liu, Gang +5 more
core +1 more source
Cells, 2022 Hypoxia stabilizes the transcription factor HIF-1α, which promotes the transcription of many genes essential to adapt to reduced oxygen levels. Besides proline hydroxylation, expression of HIF-1α is also regulated by a range of other posttranslational ...
Elie Seaayfan +8 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
HIF-1α forms a PARylated complex with PARP1.
, 2018 A) Following immunoprecipitation with IgG and PARP1 antibodies, western blot for HIF-1α confirms that PARP1 immunoprecipitates with HIF-1α to a greater extent in LMP1+ vs LMP1- cells and this is attenuated by 1 μM 72 hr olaparib treatment.
Yinfei Tan (5932118) +5 more
core +1 more source
AntioxidantsAcute liver injury (ALI) is a potentially life-threatening condition lacking effective clinical drugs. Hypoxia-inducible factor-1α (HIF-1α) is a key regulator of both inflammation and metabolism.
Jiayu Yang +11 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
HIF-1α contributes to Ang II-induced inflammatory cytokine production in podocytes
BMC Pharmacology and Toxicology, 2019 Background Studies have indicated that changed expression of hypoxia-inducible factor-1α (HIF-1α) in epithelial cells from the kidney could affect the renal function in chronic kidney disease (CKD).
Hao Huang +10 more
doaj +1 more source