Results 61 to 70 of about 151,161 (274)

Mechanism of HIF-1α Promoting Malignant Development of Nasopharyngeal Carcinoma by Upregulating PD-L1 Under Hypoxic Conditions

Zhongliu Fangzhi Yanjiu, 2021
Objective To explore the mechanism of HIF-1α promoting malignant development of nasopharyngeal carcinoma by upregulating PD-L1 expression under hypoxic conditions.
JIANG Doudou, DONG Jiawen, HU Desheng, ZHOU Yajuan   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

HIF-1α Dependent Upregulation of ZIP8, ZIP14, and TRPA1 Modify Intracellular Zn2+ Accumulation in Inflammatory Synoviocytes

, 2021
Intracellular free zinc ([Zn2+]i) is mobilized in neuronal and non-neuronal cells under physiological and/or pathophysiological conditions; therefore, [Zn2+]i is a component of cellular signal transduction in biological systems.
Matsubara, Masaki, Hiroka Suzuki, Katsuhiko Muraki, Suzuki, Hiroka, Muraki, Katsuhiko, Yukiko Muraki, Masaki Matsubara, Muraki, Yukiko, Noriyuki Hatano, Hatano, Noriyuki   +9 more
core   +1 more source

Increased HIF-1α expression in T cells and associated with enhanced Th17 pathway in systemic lupus erythematosus

Journal of the Formosan Medical Association, 2022
Background/Purpose: Recent emerging evidence indicates that dysfunction of metabolic remodeling underlies aberrant T cell immune responses in systemic lupus erythematosus (SLE).
Hsiu-Jung Liao, Ching-Liang Chu, Szu-Chieh Wang, Hua-Yi Lee, Chien-Sheng Wu   +4 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions [PDF]

, 2012
Sirtuins and hypoxia-inducible transcription factors (HIF) have well-established roles in regulating cellular responses to metabolic and oxidative stress.
Candinas Daniel, Vincent Roh, Christa Schwarz (174212), Lechleiter, Antje, Schwarz Christa, Vorburger Stephan A., Alexander Laemmle (174189), Cynthia Furer, Portmann, Simone, Deborah Stroka (174281), Deborah Stroka, Schwarz, Christa, Portmann Simone, Alexander Laemmle, Vincent Roh (161535), Stroka, Deborah, Mario P Tschan, Simone Portmann (174221), Christa Schwarz, Furer, Cynthia, Laemmle, Alexander, Tschan, Mario P, Tschan Mario P., Vorburger, Stephan A, Lechleiter Antje, Antje Lechleiter, Daniel Candinas, Furer Cynthia, Simone Portmann, Roh Vincent, Adrian Keogh (174242), Keogh, Adrian, Daniel Candinas (174264), Mario P. Tschan (174253), Candinas, Daniel, Cynthia Furer (174232), Stroka Deborah, Roh, Vincent, Laemmle Alexander, Stephan A. Vorburger (174274), Antje Lechleiter (174197), Keogh Adrian, Stephan A Vorburger, Adrian Keogh   +43 more
core   +3 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

HIF-1α promotes the keloid development through the activation of TGF-β/Smad and TLR4/MyD88/NF-κB pathways

, 2019
A keloid is defined as an overgrowth of the dense fibrous tissues that form around a wound. Since they destroy the vascular network, keloid tissues often exhibit anoxic conditions.
Xi Chu (718542), Yang Wang (5921), Rui Lei (7536488), Shizhen Zhang (6955181), Jinghong Xu (106352), Jian Li (41607), Weihan Li (1452544), Feng Liu (72874)   +7 more
core   +1 more source

NleB interacts with HIF-1α.

, 2018
(A) HIF-1α co-localized with NleB in HeLa cells and HCT116 cells. HeLa cells and HCT116 cells were transfected with GFP-tagged HIF-1α (GFP-HIF-1α) together with RFP-tagged NleB and then examined by a Zeiss confocal microscope (LSM-710).
Huangyuan Zha (5646368), Xing Liu (221084), Wuhan Xiao (206571), Chenxi Xu (2880902), Dawei Zhang (58801), Sijia Fan (5646371), Shan Li (110392)   +6 more
core   +1 more source

Dose-dependent effects of Allopurinol on human foreskin fibroblast cell and human umbilical vein endothelial cell under hypoxia [PDF]

, 2015
Allopurinol, an inhibitor of xanthine oxidase, has been used in clinical trials of patients with cardiovascular and chronic kidney disease. These are two pathologies with extensive links to hypoxia and activation of the transcription factor hypoxia ...
Sun, Yu, George Jacob, Sun Yu, Yu Sun, Sonia Rocha, Jacob George, George, Jacob, Rocha, Sonia, Rocha Sonia   +8 more
core   +1 more source