Results 81 to 90 of about 136,040 (279)

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

Hypoxia-inducible factor-1α as a biomarker for individuals under hypoxia duration and pattern in fat greenling Hexagrammos otakii

Aquaculture Reports
Background: One common environmental stressor in fisheries is hypoxia stress, which frequently causes significant fish mortality and financial losses. This study aimed to examine the potential utility of serum concentrations of hypoxia-inducible factor ...
Yu Zhan, Xin Qi, Yiting Wu, Dongxu Gao, Ling Zhao, Shengnan Cao, Zhuang Xue, Wei Wang   +7 more
doaj   +1 more source

Effects of HIF-1α on ERRα/γ protein expression in mouse skeletal muscle [PDF]

, 2015
Aims: HIF-1α plays an important role in the adaptive responses to hypoxia. The ERRα and γ are crucial regulators of energy metabolism in skeletal muscle.
Liu, Gang, Ji, Weixiu, Zhang, Lianfeng, Zhang, Ying, Wang, Jianxiong, Liu, Sixue   +5 more
core  

HIF-1α synthesis in hypoxia.

, 2015
HIF-1α level at time zero is the steady state normoxic (21% O2) level. (A) Total HIF-1α expression profiles are highly sensitive to oxygen availability.
Aleksander S. Popel (134255), Chen Zhao (225070)   +1 more
core   +1 more source

New insights into the key role of HIF-1α in IL-10-producing B cells [PDF]

, 2018
Hypoxia-inducible factors (HIFs) are essential transcription factors for the cellular response to hypoxia. Expression and stabilization of HIFs can be triggered by hypoxia or by other factors under pathological stress such as inflammation and infection ...
Xianyi Meng, Aline Bozec
core   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease

Molecular Neurodegeneration, 2010
Background Mutations in presenilin-1 (Psen1) cause familial Alzheimer's disease (FAD). Both hypoxia and ischemia have been implicated in the pathological cascade that leads to amyloid deposition in AD.
Sosa Miguel, De Gasperi Rita, Dracheva Stella, Elder Gregory A   +3 more
doaj   +1 more source

HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer. [PDF]

PLoS ONE, 2015
It is well recognized that hypoxia-inducible factor 1 alpha (HIF-1α) is involved in cancer metastasis, chemotherapy and poor prognosis. We previously found that deferoxamine, a hypoxia-mimetic agent, induces epithelial-mesenchymal transition (EMT) in ...
Wenjing Zhang, Xinpeng Shi, Ying Peng, Meiyan Wu, Pei Zhang, Ruyi Xie, Yao Wu, Qingqing Yan, Side Liu, Jide Wang   +9 more
doaj   +1 more source

Immunohistochemistry for HIF-1α and HIF-1β.

, 2015
HIF, Hypoxia inducible factorImmunohistochemistry for HIF-1α and HIF-1β.
Najla Fakhruddin (750404), Marwan El-Sabban (317103), Lamis Yehia (750403), Fouad Boulos (631067), Mark Jabbour (631068), Ziyad Mahfoud (15883)   +5 more
core   +1 more source

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source