Results 101 to 110 of about 136,719 (278)

DMAG-induced inhibition of HIF-1α expression. [PDF]

, 2013
As a complementary approach to siRNAHIF-1α treatment, DMAG-induced inhibition of HIF-1α levels in vivo (A) was examined by ELISA in the normal (uninfected) cornea and at 5 days after ocular infection. HIF-1α protein was significantly reduced at both time
Sharon A. McClellan (434587), Linda D. Hazlett (434588), Elizabeth A. Berger (434586), Kerry S. Vistisen (164917)   +3 more
core   +1 more source

Downregulation of Hypoxia-Inducible Factor-1α by RNA Interference Alleviates the Development of Collagen-Induced Arthritis in Rats

Molecular Therapy: Nucleic Acids, 2020
Rheumatoid arthritis (RA) is the most common type of autoimmune arthritis. Hypoxia-inducible factor-1α (HIF-1α) as a transcription factor in response to hypoxia suggests that it could be a potential therapeutic target for the treatment of RA.
Yiping Hu, Tiantian Zhang, Jingqin Chen, WenXiang Cheng, Jianhai Chen, Zhengtan Zheng, Jietao Lin, Guoyuan Zhu, Yong Zhang, Xueling Bai, Yan Wang, Bing Song, Qingwen Wang, Ling Qin, Peng Zhang   +14 more
doaj   +1 more source

Tumor‐Targeted Hyaluronic Acid/Tannic Acid‐Engineered Oxygen Nanogenerators With IR780 Payloads Enable Dual‐Mode Glutathione Depletion and Effective Singlet Oxygen Generation for Melanoma Treatment

Advanced Healthcare Materials, EarlyView.
A hyaluronic acid/tannic acid‐engineered Prussian blue oxygen nanogenerator loaded with IR780 is developed to enhance melanoma phototherapy. By integrating tumor targeting, oxygen self‐supply, and dual‐mode glutathione depletion, the nanoplatform effectively overcomes hypoxia and antioxidant defenses, potentiating synergistic photothermal/photodynamic ...
Chai‐How Hsu, I‐Ju Liu, Hsiang‐Yun Chih, Tsai‐Ching Hsu, Ju‐An Liang, Chia‐Wei Kuo, Bor‐Show Tzang, Wen‐Hsuan Chiang   +7 more
wiley   +1 more source

1, 9 PA downregulates HIF-1α in a PHD- and HIF-1α ODD-dependent manner. [PDF]

, 2013
(A) Requirement of O2 and Fe2+ in the 1, 9 PA-induced downregulation of HIF-1α. A431 cells were untreated or treated with 10 µM 1, 9 PA in 0.5% FBS culture medium under normoxic conditions in the absence or presence of DFO (100 µM) or MG132 (10 µM), and ...
Yang Lu (59885), Zhen Fan (59888), Haiquan Lu (358224), Xinqun Li (59884)   +3 more
core   +1 more source

Overcoming Photodynamic Therapy Resistance: GSH‐Responsive AIE Photosensitizer‐Hydroxycamptothecin Nanoliposomes for Extrahepatic Cholangiocarcinoma

Advanced Healthcare Materials, EarlyView.
A GSH‐responsive AIE nanoplatform (TSH NPs) with RGD‐mediated tumor targeting co‐delivers a photosensitizer (TPA) and HCPT for extrahepatic cholangiocarcinoma. The system synergistically enhances PDT and chemotherapy by suppressing HIF‐1α/VEGF‐driven hypoxic adaptation, effectively overcoming PDT resistance.
Yong Qu, Tao Peng, Yating Zhang, Juanmei Cao, Birong Wang, Chuxing Chai, Zhiyuan Gao, Yiting Xu, Yifan Jin, Yuqing Wang, Zhuoxia Li, Xu Liu, Tianqi Zhao, Yufan Chen, Weimin Lv, Di Lu, Changzheng Huang, Dan Ding, Jinxiang Zhang, Min Li   +19 more
wiley   +1 more source

Expression of Hypoxia Inducible Factor-1α (HIF-1α) via Photodynamic Therapy in Oral Squamous Cell Carcinoma [PDF]

, 2010
口腔癌的排名有逐年上升的趨勢，年增率高居癌症第一位，死亡率過半。癌症治療的方式多樣化，目地在延長病患壽命，甚至進一步治癒癌症。以手術切除常因造成顏面傷殘及病患心理壓力而放棄，為尋求減少侵犯性治療，進行新興的光動力治療。光動力治療(Photodynamic therapy, PDT)是新興的癌症治療的方式，光動力治療已運用在其它不易手術部位的癌療。光動力治療的藥物也有進一步的改善，先前我們採用新研發的二代光感藥物(photosensitizer) 5-氨基酮戊酸(5-aminolevulinic acid,
曾建福, Tseng, Chien-Fu
core  

Age-Related Expression and Localization of HIF-1α and HIF-2α in Different Tissues of Yak

Oxygen
The yak (Bos grunniens), a unique bovine species that is endemic to the Qinghai–Tibet Plateau and adjacent mountainous regions, exhibits remarkable adaptations to chronic high-altitude hypoxia.
Qin Wu, Huan Yang, Junyu Chen, Zhixin Chai, Hongwen Zhao, Zhijuan Wu   +5 more
doaj   +1 more source

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

Advanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn, Gyu Tae Park, Dongjun Lee, Sik Yoon, Sae‐Ock Oh, Jae Ho Kim, Byoung Soo Kim   +6 more
wiley   +1 more source

Identification of a MET-eIF4G1 translational regulation axis that controls HIF-1α levels under hypoxia. [PDF]

, 2018
Poor oxygenation is a common hallmark of solid cancers that strongly associates with aggressive tumor progression and treatment resistance. While a hypoxia-inducible factor 1α (HIF-1α)-associated transcriptional overexpression of the hepatocyte growth ...
Daniel M. Aebersold, Medova, Michaela, Bubendorf, Lukas, Nisa Hernández, Lluís, Lluís Nisa, Jacopo Gavini, Aebersold, Daniel, Poliakova, Michaela, Dominic Leiser, Michaela Poliaková, Aurélie Quintin, Quintin, Aurélie, Keogh-Stroka, Deborah M., Michaela Medová, Gavini, Jacopo, Astrid A. Glück, Berezowska, Sabina, Blaukat, Andree, Orlando, Eleonora, Lukas Bubendorf, Yitzhak Zimmer, Eleonora Orlando, Leiser, Dominic, Andree Blaukat, Sabina Berezowska, Glück, Astrid Andreina, Zimmer, Yitzhak, Deborah M. Stroka   +27 more
core   +1 more source

Overexpression of Hypoxia-Inducible Factor-1α Exacerbates Endothelial Barrier Dysfunction Induced by Hypoxia

Cellular Physiology and Biochemistry, 2013
Background/Aims: The mechanisms involved in endothelial barrier dysfunction induced by hypoxia are incompletely understood. There is debate about the role of hypoxia-inducible factor-1α (HIF-1α) in endothelial barrier disruption.
Pei Wang, Huabing Qi, Chunhong Sun, Wen He, Gang Chen, Li Li, Fengjun Wang   +6 more
doaj   +1 more source