Results 101 to 110 of about 136,040 (279)

Hypoxia-inducible factor 1 alpha expression increases during colorectal carcinogenesis and tumor progression

BMC Cancer, 2008
Background Hypoxia-inducible factor 1 alpha (HIF-1α) is involved in processes promoting carcinogenesis of many tumors. However, its role in the development of colorectal cancer is unknown.
Jayasinghe Caren, Taxeidis Marios, Simiantonaki Nektaria, Kurzik-Dumke Ursula, Kirkpatrick Charles   +4 more
doaj   +1 more source

Prx1 regulates HIF-1α expression.

, 2013
A. 2H-11 cells were stimulated with 20 nM rPrx1. Total RNA was collected at various times after stimulation and qPCR was performed with HIF-1α specific primers.
Sandra O. Gollnick (297886), Jonah R. Riddell (297880), Patricia Maier (297882), Stephanie N. Sass (297884), Barbara A. Foster (255172), Michael T. Moser (297885)   +5 more
core   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

EGC promotes HIF-1α proteasome pathway degradation.

, 2013
(A) Expression curve of HIF-1α under hypoxia. The results showed that the expression level of HIF-1α reached the peak at the 6th hour, but had a slight decrease after 10 hours; (B) EGC inhibited HIF-1α expression in a dose-dependent manner in both breast
Zhiyu Wang (282312), Jianping Chen (54279), Tjing Yung Loo (282317), Dongmei Wang (282313), Feizhi Mo (282316), Shouwei Han (282314), Neng Wang (282315), Jiangang Shen (211160), Hui Huang (4122)   +8 more
core   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Additional file 1 of AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth

, 2023
Additional file 1: Table S1. Enriched top 10 gene ontology annotations for biological process in transcriptome of S/G-deprived U87MG cells, compared to control. Table S2.
Linyong Du (7006637), Seok-Ho Kim (2300827), Je Sun Lim (17641892), Su Hwan Park (15158181), Rui Liu (54031), Dong Guo (442625), Zhimin Lu (192492), Min Li (12799), Seong-il Eyun (549328), Jong-Ho Lee (17641895), Hye Jin Yun (15426381), So Mi Jeon (17641889), Su Bin Lee (9958069), Tae Hwan Shin (5472662), Yun-Yong Park (12894)   +14 more
core   +1 more source

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Overexpression of Hypoxia-Inducible Factor-1α Exacerbates Endothelial Barrier Dysfunction Induced by Hypoxia

Cellular Physiology and Biochemistry, 2013
Background/Aims: The mechanisms involved in endothelial barrier dysfunction induced by hypoxia are incompletely understood. There is debate about the role of hypoxia-inducible factor-1α (HIF-1α) in endothelial barrier disruption.
Pei Wang, Huabing Qi, Chunhong Sun, Wen He, Gang Chen, Li Li, Fengjun Wang   +6 more
doaj   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem Cells

Advanced Science, EarlyView.
In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, Chao Tong, Ling Shuai   +11 more
wiley   +1 more source