Results 1 to 10 of about 35,931 (278)

Transformer 2 alpha homolog is a downstream gene of hypoxia-inducible factor 1 subunit alpha and is involved in the progression of pancreatic cancer

Bioengineered, 2022
Intratumoral hypoxia is a common feature of pancreatic cancer (PC) and also plays a role in its progression. However, hypoxia-regulated signatures in PC are still not completely understood. This study aimed to identify core hypoxia-associated genes and determine their underlying molecular mechanisms in PC cells.
Wenpeng Cao, Shan Lei, Zhirui Zeng
exaly   +4 more sources

Suppression of collagen IV alpha‐2 subunit by prolyl hydroxylase domain inhibition via hypoxia‐inducible factor‐1 in chronic kidney disease [PDF]

Pharmacology Research & Perspectives, 2021
Elevation of hypoxia‐inducible factor 1 protein has been shown to be protective in acute kidney injury and HIF1α enhancing drug therapies are currently in clinical trials for the treatment of anemia of chronic kidney disease.
Mohammad Sanaei‐Ardekani, Shyreen Kamal, Whitney Handy, Sidrah Alam, Aya Salaheldin, Anderson Moore, Shahrzad Movafagh   +6 more
doaj   +4 more sources

Hypoxia inducible factor 1 subunit alpha mediates autophagy disorder of oral lichen planus by regulating lysosomal pathway [PDF]

Frontiers in Immunology
Oral lichen planus (OLP), known as a common and chronic mucosal inflammatory disease. Due to its potential for cancerous transformation, this disease has long been a subject of significant concern.
Xie Li, Xie Li, Chao Han, Chao Han, Yuemei Yao, Yuemei Yao, Yuanxin Shi, Bin Chen, Yi Xiao, Yi Xiao, Guohui Bai   +10 more
doaj   +3 more sources

Long non-coding RNA COL4A2-AS1 facilitates cell proliferation and glycolysis of colorectal cancer cells via miR-20b-5p/hypoxia inducible factor 1 alpha subunit axis. [PDF]

Bioengineered, 2021
Long non-coding RNAs (lncRNAs) have critical functions in tumorigenesis and progression of colorectal cancer (CRC). The role of lncRNA COL4A2-AS1 (COL4A2-AS1) lacks system investigation. The current study comprehensively analyzed the expression, biological functions, and mechanism of COL4A2-AS1 in CRC through performing real-time quantitative PCR (RT ...
Yu Z, Wang Y, Deng J, Liu D, Zhang L, Shao H, Wang Z, Zhu W, Zhao C, Ke Q.   +9 more
europepmc   +4 more sources

The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis [PDF]

BMC Cancer, 2019
Background The rs2057482 polymorphism in the hypoxia inducible factor 1 subunit alpha (HIF1A) gene has been reported to be associated with a risk of several types of cancer, but this association has not yet been definitively confirmed.
Li-Fang Wu, Gui-Ping Xu, Qing Zhao, Li-Jing Zhou, Ding Wang, Wei-Xian Chen   +5 more
doaj   +3 more sources

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit [PDF]

Journal of Biological Chemistry, 1997
Hypoxia-inducible factor-1 (HIF-1), a heterodimeric DNA binding complex composed of two basic-helix-loop-helix Per-AHR-ARNT-Sim proteins (HIF-1alpha and -1beta), is a key component of a widely operative transcriptional response activated by hypoxia, cobaltous ions, and iron chelation.
Pugh, C, O'Rourke, J, Nagao, M, Gleadle, J, Ratcliffe, P   +4 more
openaire   +4 more sources

Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones [PDF]

Gastroenterology, 2017
Hypoxia-inducible factor 1α subunit (HIF1A) is a transcription factor that controls the cellular response to hypoxia and is activated in hepatocytes of patients with nonalcoholic fatty liver disease (NAFLD). NAFLD increases the risk for cholesterol gallstone disease by unclear mechanisms.
Yoichirô Asai, Sohei Tsukita, Masamitsu Maekawa   +2 more
exaly   +3 more sources

Endurance training increases tmTNF-α and IL-6 levels in several vital organs in rats: relationship with hypoxia markers [PDF]

Frontiers in Molecular Biosciences
BackgroundAlthough endurance training is known to induce systemic adaptations involving inflammatory and hypoxia-related signaling, tissue-specific protein responses remain incompletely understood.
Lukasz Galganski, Jerzy A. Zoladz, Wieslawa Jarmuszkiewicz   +2 more
doaj   +2 more sources

Analysis of Migration and Adaptive Evolution in Tibetan Sheep Populations [PDF]

Animals
The genetic basis for Tibetan sheep adaptation to different high-altitude environments remains unknown. This study conducted whole-genome resequencing on 80 Tibetan sheep individuals from four major distribution areas on the Qinghai–Tibet Plateau.
Wentao Zhang, Chao Yuan, Tingting Guo, Bowen Chen, Fan Wang, Jianbin Liu, Zengkui Lu   +6 more
doaj   +2 more sources

mRNA overexpression of the hypoxia inducible factor 1 alpha subunit gene (HIF1A): An independent predictor of poor overall survival in chronic lymphocytic leukemia

Leukemia Research, 2017
The hypoxia inducible factor 1 (HIF1) is a heterodimeric transcription factor that ultimately regulates cellular responses to changes in oxygen tension. In this study, we examined the potential diagnostic and prognostic potential of the mRNA expression of HIF1 regulatory α-subunit (HIF1A) in chronic lymphocytic leukemia (CLL).
Christos K Kontos, Sotirios G Papageorgiou, Andreas Scorilas   +2 more
exaly   +4 more sources