Suppression of collagen IV alpha‐2 subunit by prolyl hydroxylase domain inhibition via hypoxia‐inducible factor‐1 in chronic kidney disease [PDF]
Pharmacology Research & Perspectives, 2021 Elevation of hypoxia‐inducible factor 1 protein has been shown to be protective in acute kidney injury and HIF1α enhancing drug therapies are currently in clinical trials for the treatment of anemia of chronic kidney disease.
Mohammad Sanaei‐Ardekani +6 more
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Endurance training increases tmTNF-α and IL-6 levels in several vital organs in rats: relationship with hypoxia markers [PDF]
Frontiers in Molecular BiosciencesBackgroundAlthough endurance training is known to induce systemic adaptations involving inflammatory and hypoxia-related signaling, tissue-specific protein responses remain incompletely understood.
Lukasz Galganski +2 more
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Analysis of Migration and Adaptive Evolution in Tibetan Sheep Populations [PDF]
AnimalsThe genetic basis for Tibetan sheep adaptation to different high-altitude environments remains unknown. This study conducted whole-genome resequencing on 80 Tibetan sheep individuals from four major distribution areas on the Qinghai–Tibet Plateau.
Wentao Zhang +6 more
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Effect of melatonin on steroidogenesis-related enzymes expression and testosterone synthesis following CoCl2-induced hypoxia in TM3 Leydig cells [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): This study examined the effects of melatonin treatment on steroidogenesis dysfunction and testosterone impairment, following CoCl2-induced hypoxia in TM3 Leydig cells. Materials and Methods: The TM3 cells were divided into four groups.
shokooh karimi +4 more
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The possible role of hypoxia in the affected tissue of relapsed clubfoot
Scientific Reports, 2022 Our aim was to study the expression of hypoxia-related proteins as a possible regulatory pathway in the contracted side tissue of relapsed clubfoot. We compared the expression of hypoxia-related proteins in the tissue of the contracted (medial) side of ...
Tomas Novotny +9 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 ObjectivesComplement 1q binding protein (C1QBP/HABP1/p32/gC1qR) has been found to be overexpressed in triple-negative breast cancer (TNBC). However, the underlying mechanisms of high C1QBP expression and its role in TNBC remain largely unclear.
Hao Wu +31 more
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Inhibiting miR-155 protects against myocardial ischemia/reperfusion injury via targeted regulation of HIF-1α in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): The aim of this study was to identify the role of miR-155 in the myocardial ischemia/reperfusion (I/R) injury through targeting hypoxia-inducible factor 1-alpha (HIF-1α).
Jian-Guo Chen +3 more
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Regulation of the SIAH2-HIF-1 Axis by Protein Kinases and Its Implication in Cancer Therapy
Frontiers in Cell and Developmental Biology, 2021 The cellular response to hypoxia is a key biological process that facilitates adaptation of cells to oxygen deprivation (hypoxia). This process is critical for cancer cells to adapt to the hypoxic tumor microenvironment resulting from rapid tumor growth.
Dazhong Xu, Cen Li
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Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship
Molecular Cancer, 2023 Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone microenvironment where Ewing sarcoma (EwS) – a highly aggressive pediatric cancer – mainly arises. Hypoxia
A. Katharina Ceranski +5 more
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Frontiers in Oncology, 2023 BackgroundHypoxia-inducible factor 1-alpha (HIF-1α) stability and transcriptional action are reduced by the hypoxia-inducible factor 1-alpha subunit suppressor (HIF1AN). Its inappropriate expression is associated with the development of cancer and immune
Shasha Tang +8 more
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