Results 31 to 40 of about 35,931 (278)
Chinese Medical Journal, 2017 Background: Endometriosis (EMs) is a common gynecological disorder characterized by endometrial-like tissue outside the uterus. Hypoxia induces the expression of many important downstream genes to regulate the implantation, survival, and maintenance of ...
Yue-Xin Yu +3 more
doaj +1 more source
Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities [PDF]
, 2014 E3 ubiquitin ligases are attractive targets in the ubiquitin-proteasome system, however, the development of small-molecule ligands has been rewarded with limited success.
Dias, David M +20 more
core +1 more source
Progress in Fishery Sciences, 2023 Fish meal and fish oil are important sources of protein and lipid in feeds. The lack of fish meal and fish oil supply has become an important limiting factor for the aquaculture industry.
Shuqing SONG +5 more
doaj +1 more source
Chinese Medical Journal, 2020 Abstract Background: Mesenchymal stem or stromal cells (MSCs) derived from the induced pluripotent stem cells (iPSCs) have uniform biological activity, which makes the clinical application of MSCs in bone repair possible.
Jing-Yi Li +7 more
openaire +3 more sources
In vivo imaging of brain ischemia using an oxygen-dependent degradative fusion protein probe. [PDF]
PLoS ONE, 2012 Within the ischemic penumbra, blood flow is sufficiently reduced that it results in hypoxia severe enough to arrest physiological function. Nevertheless, it has been shown that cells present within this region can be rescued and resuscitated by restoring
Youshi Fujita +9 more
doaj +1 more source
DNA Micro-Array Gene Expression Profiling of Angiogenesis in Collagen Gel Culture
Clinical Medicine Insights: Cardiology, 2008 We examined angiogenesis-related gene expression profiles using collagen gel culture and a DNA chip. After isolation of total RNA from cultures before and after capillary tube formation, a mouse whole-genome array study was performed.
Masumi Akita, Keiko Fujita
doaj +1 more source
Iranian Journal of Allergy, Asthma and Immunology, 2022 It is believed that preformed antibodies are responsible for blood transfusion reactions and transplant rejections. In order to remove a tumor, the tissue must be rejected.
Erfan Basirat +3 more
doaj +1 more source
Kaohsiung Journal of Medical Sciences, 2021 Long noncoding RNA (lncRNA) Cancer Susceptibility 2 (CASC2) has been proved to contribute to the development of cancers. However, the mechanism behind the action of CASC2 in thyroid cancer is not quite clear.
Qi‐Yu Liu +8 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Hypoxia-driven microRNA-27b underlies pathologic cardiac endoreplication in heart disease
Signal Transduction and Targeted TherapyHeart disease is characterized by stress-induced endoreplication preceding pathological cardiomyocyte overgrowth, yet the upstream regulatory mechanisms linking tissue hypoxia to aberrant cellular growth remain incompletely defined.
Peter Mirtschink +23 more
doaj +1 more source