Results 31 to 40 of about 33,359,923 (277)

Transforming Growth Factor-beta 1 Involved in the Pathogenesis of Endometriosis through Regulating Expression of Vascular Endothelial Growth Factor under Hypoxia

Chinese Medical Journal, 2017
Background: Endometriosis (EMs) is a common gynecological disorder characterized by endometrial-like tissue outside the uterus. Hypoxia induces the expression of many important downstream genes to regulate the implantation, survival, and maintenance of ...
Yue-Xin Yu, Yin-Ling Xiu, Xi Chen, Ya-Li Li   +3 more
doaj   +1 more source

Effects of Dietary Starch and Dextrin on Growth and Hypoxia Tolerance in Tiger Puffer (Takifugu rubripes)

Progress in Fishery Sciences, 2023
Fish meal and fish oil are important sources of protein and lipid in feeds. The lack of fish meal and fish oil supply has become an important limiting factor for the aquaculture industry.
Shuqing SONG, Yuexing ZHANG, Qiang MA, Houguo XU, Yuliang WEI, Mengqing LIANG   +5 more
doaj   +1 more source

Semaphorin 3A-hypoxia inducible factor 1 subunit alpha co-overexpression enhances the osteogenic differentiation of induced pluripotent stem cells-derived mesenchymal stem cells in vitro

Chinese Medical Journal, 2020
Abstract Background: Mesenchymal stem or stromal cells (MSCs) derived from the induced pluripotent stem cells (iPSCs) have uniform biological activity, which makes the clinical application of MSCs in bone repair possible.
Jing-Yi Li, Ting-Ting Wang, Chong Li, Zhi-Fang Wang, Shan Li, Li Ma, Li-Li Zheng, Li-Shao Guo   +7 more
openaire   +3 more sources

Hypoxia-inducible factor 1 alpha in oral squamous cell carcinoma and its relation to prognosis [PDF]

, 2009
The aim of this study was to investigate the correlation between the expression of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and proliferative activity in tumor cells, lymph node metastasis, as well as prognosis in patients with oral squamous cell ...
Uehara, Masataka, Asahina, Izumi, Izumi Asahina, Mihoko Nonaka, Ikeda, Hisazumi, Sano, Kazuo, Masataka Uehara, Nonaka, Mihoko, Hisazumi Ikeda, Kazuo Sano   +9 more
core   +1 more source

Analysis of Migration and Adaptive Evolution in Tibetan Sheep Populations

Animals
The genetic basis for Tibetan sheep adaptation to different high-altitude environments remains unknown. This study conducted whole-genome resequencing on 80 Tibetan sheep individuals from four major distribution areas on the Qinghai–Tibet Plateau.
Wentao Zhang, Chao Yuan, Tingting Guo, Bowen Chen, Fan Wang, Jianbin Liu, Zengkui Lu   +6 more
doaj   +1 more source

Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways [PDF]

, 2013
The DNA-damaging agent camptothecin (CPT) and its analogs demonstrate clinical utility for the treatment of advanced solid tumors, and CPT-based nanopharmaceuticals are currently in clinical trials for advanced kidney cancer; however, little is known ...
Ashcroft, M, Carroll, VA, Selvarajah, J, Moumen, A, Nathawat, K   +4 more
core   +2 more sources

Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]

, 2014
Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival ...
Biddlestone, John, Mudie, Sharon, Bandarra, Daniel, Muller, H. Arno, Rocha, Sonia   +4 more
core   +1 more source

In vivo imaging of brain ischemia using an oxygen-dependent degradative fusion protein probe. [PDF]

PLoS ONE, 2012
Within the ischemic penumbra, blood flow is sufficiently reduced that it results in hypoxia severe enough to arrest physiological function. Nevertheless, it has been shown that cells present within this region can be rescued and resuscitated by restoring
Youshi Fujita, Takahiro Kuchimaru, Tetsuya Kadonosono, Shotaro Tanaka, Yoshiki Hase, Hidekazu Tomimoto, Masahiro Hiraoka, Shinae Kizaka-Kondoh, Masafumi Ihara, Ryosuke Takahashi   +9 more
doaj   +1 more source

Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival. [PDF]

, 2007
Sepsis patients may die either from an overwhelming systemic immune response and/or from an immunoparalysis-associated lack of anti-bacterial immune defence. We hypothesized that bacterial superantigen-activated T cells may be prevented from contribution
Kreth Simone, Sitkovsky Michail V., Sitkovsky, Michail V., Alex B Lentsch, Lukashev, Dmitry, Lentsch Alex B., Michail V Sitkovsky, Kreth, Simone, Smith Patrick, Smith, Patrick, Kuboki, Satoshi, P Chen, Caldwell Charles C., Lukashev Dmitry, Akio Ohta, Manfred Thiel, Chen P., Caldwell, Charles C., Lentsch, Alex B., Dmitry Lukashev, Chen, P., Patrick Smith, Kuboki Satoshi, Satoshi Kuboki, Thiel, Manfred, Ohta, Akio, Thiel Manfred, Ohta Akio, Charles C Caldwell, Simone Kreth   +29 more
core   +1 more source

DNA Micro-Array Gene Expression Profiling of Angiogenesis in Collagen Gel Culture

Clinical Medicine Insights: Cardiology, 2008
We examined angiogenesis-related gene expression profiles using collagen gel culture and a DNA chip. After isolation of total RNA from cultures before and after capillary tube formation, a mouse whole-genome array study was performed.
Masumi Akita, Keiko Fujita
doaj   +1 more source