Results 31 to 40 of about 65,547 (283)

Biology of advanced uveal melanoma and next steps for clinical therapeutics [PDF]

, 2014
Uveal melanoma is the most common intraocular malignancy although it is a rare subset of all melanomas. Uveal melanoma has distinct biology relative to cutaneous melanoma, with widely divergent patient outcomes.
Bastian, BC, Bowcock, AM, Carvajal, RD, Flaherty, KT, Gershenwald, JE, Gutkind, JS, Luke, JJ, McKenna, KC, Patel, PM, Sato, T, Selig, S, Sossman, JA, Streicher, HZ, Sznol, M, Thurin, M, Triozzi, PL, Van Meir, EG, Welch, J   +17 more
core   +1 more source

Semaphorin 3A-hypoxia inducible factor 1 subunit alpha co-overexpression enhances the osteogenic differentiation of induced pluripotent stem cells-derived mesenchymal stem cells in vitro

Chinese Medical Journal, 2020
Abstract Background: Mesenchymal stem or stromal cells (MSCs) derived from the induced pluripotent stem cells (iPSCs) have uniform biological activity, which makes the clinical application of MSCs in bone repair possible.
Jing-Yi Li, Ting-Ting Wang, Chong Li, Zhi-Fang Wang, Shan Li, Li Ma, Li-Li Zheng, Li-Shao Guo   +7 more
openaire   +3 more sources

Sequence and functional characterization of hypoxia inducible factors, HIF1α, HIF2αa, and HIF3α, from the estuarine fish, Fundulus heteroclitus [PDF]

, 2016
Author Posting. © The Author(s), 2016. This is the author's version of the work. It is posted here under a nonexclusive, irrevocable, paid-up, worldwide license granted to WHOI. It is made available for personal use, not for redistribution.
Hahn, Mark E., Karchner, Sibel I., Rees, Bernard B., Skripnikova, Elena, Townley, Ian K., Wiese, Thomas E.   +5 more
core   +1 more source

Effects of Dietary Starch and Dextrin on Growth and Hypoxia Tolerance in Tiger Puffer (Takifugu rubripes)

Progress in Fishery Sciences, 2023
Fish meal and fish oil are important sources of protein and lipid in feeds. The lack of fish meal and fish oil supply has become an important limiting factor for the aquaculture industry.
Shuqing SONG, Yuexing ZHANG, Qiang MA, Houguo XU, Yuliang WEI, Mengqing LIANG   +5 more
doaj   +1 more source

Bioinformatic Analysis for the Validation of Novel Biomarkers for Cancer Diagnosis and Drug Sensitivity [PDF]

, 2015
Background: The genetic control of tumour progression presents the opportunity for bioinformatics and gene expression data to be used as a basis for tumour grading.
Lockwood, Laura Anne Rebecca
core   +2 more sources

Role of arginase 2 in systemic metabolic activity and adipose tissue fatty acid metabolism in diet-induced obese mice [PDF]

, 2019
Visceral adipose tissue (VAT) inflammation and metabolic dysregulation are key components of obesity-induced metabolic disease. Upregulated arginase, a ureahydrolase enzyme with two isoforms (A1-cytosolic and A2-mitochondrial), is implicated in ...
Atawia, Reem T, Benson, Tyler W, Caldwell, Robert W, Caldwell, Ruth B, Cutler, Christopher W, Meghil, Mohamed M, Toque, Haroldo A, Weintraub, Neal L, Yiew, Nicole K.H   +8 more
core   +2 more sources

Hypoxia inducible factor 1 subunit alpha mediates autophagy disorder of oral lichen planus by regulating lysosomal pathway

Frontiers in Immunology
Oral lichen planus (OLP), known as a common and chronic mucosal inflammatory disease. Due to its potential for cancerous transformation, this disease has long been a subject of significant concern.
Xie Li, Xie Li, Chao Han, Chao Han, Yuemei Yao, Yuemei Yao, Yuanxin Shi, Bin Chen, Yi Xiao, Yi Xiao, Guohui Bai   +10 more
doaj   +1 more source

In vivo imaging of brain ischemia using an oxygen-dependent degradative fusion protein probe. [PDF]

PLoS ONE, 2012
Within the ischemic penumbra, blood flow is sufficiently reduced that it results in hypoxia severe enough to arrest physiological function. Nevertheless, it has been shown that cells present within this region can be rescued and resuscitated by restoring
Youshi Fujita, Takahiro Kuchimaru, Tetsuya Kadonosono, Shotaro Tanaka, Yoshiki Hase, Hidekazu Tomimoto, Masahiro Hiraoka, Shinae Kizaka-Kondoh, Masafumi Ihara, Ryosuke Takahashi   +9 more
doaj   +1 more source

HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium [PDF]

, 2013
Background: While acute lung injury (ALI) contributes significantly to critical illness, it resolves spontaneously in many instances. The majority of patients experiencing ALI require mechanical ventilation.
Bonney, Megan, Borchers, Christoph H., Brodsky, Kelley, Eckle, Tobias, Eltzschig, Holger K., Han, Jun, Kominsky, Douglas J., Mariani, Thomas J., Mittelbronn, Michel Guy André, Packard, Thomas   +9 more
core   +3 more sources

Vascular Growth in the Fetal Lung [PDF]

, 2011
The structure of the lung is truly remarkable. It is primarily composed of three branched tubular networks (the airway, pulmonary artery and vein, bronchial artery and vein) which supply blood and air to the site of gas exchange and which maintain ...
Land, Stephen
core   +4 more sources