Results 31 to 40 of about 132,147 (252)

DNA Micro-Array Gene Expression Profiling of Angiogenesis in Collagen Gel Culture

Clinical Medicine Insights: Cardiology, 2008
We examined angiogenesis-related gene expression profiles using collagen gel culture and a DNA chip. After isolation of total RNA from cultures before and after capillary tube formation, a mouse whole-genome array study was performed.
Masumi Akita, Keiko Fujita
doaj   +1 more source

In vitro and in vivo Evidence on Intra-tumor Injection of Allogeneic Serum for Immunotherapy in a Mouse Model of Colon Cancer

Iranian Journal of Allergy, Asthma and Immunology, 2022
It is believed that preformed antibodies are responsible for blood transfusion reactions and transplant rejections. In order to remove a tumor, the tissue must be rejected.
Erfan Basirat, Danial Dehghan, Ardeshir Abbasi, Nafiseh Pakravan   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Hypoxia-driven microRNA-27b underlies pathologic cardiac endoreplication in heart disease

Signal Transduction and Targeted Therapy
Heart disease is characterized by stress-induced endoreplication preceding pathological cardiomyocyte overgrowth, yet the upstream regulatory mechanisms linking tissue hypoxia to aberrant cellular growth remain incompletely defined.
Peter Mirtschink, Ting Yuan, Corinne Bischof, Minh Duc Pham, Chaonan Zhu, Akshay Ware, Yijie Mao, Meiqian Wu, Eva-Maria Rogg, Katharina Bottermann, Suam Gonzalez-Gonoggia, Corinne Berthonneche, Bettina Gercken, Eman Hagag, Katrin Strassburger, Samuel Sossalla, Sebastian N. Stehr, Wesley Abplanalp, Nicola Zamboni, Fabio Martelli, Thierry Pedrazzini, Markus Stoffel, Stefanie Dimmeler, Jaya Krishnan   +23 more
doaj   +1 more source

Liraglutide Enhances Cell Viability and Reduces Oxidative Stress in Hyperglycemic H9c2 Cardiomyocytes

Medicina
Background and Objectives: Cardiovascular disease remains a leading cause of mortality in Diabetes mellitus (DM), where chronic hyperglycemia induces oxidative stress, mitochondrial dysfunction, and hypoxia in cardiomyocytes.
Sinem Durmus, Zeki Dogan, Dilek Duzgun Ergun, Mahmut Ozdemir, Hakan Sahin, Gozde Erkanli Senturk, Remise Gelisgen, Hafize Uzun   +7 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

CASC2 inhibits the growth, migration, and invasion of thyroid cancer cells through sponging miR‐18a‐5p/FIH1 axis

Kaohsiung Journal of Medical Sciences, 2021
Long noncoding RNA (lncRNA) Cancer Susceptibility 2 (CASC2) has been proved to contribute to the development of cancers. However, the mechanism behind the action of CASC2 in thyroid cancer is not quite clear.
Qi‐Yu Liu, Ling‐Yi Gao, Lin Xu, Xiao‐Long Zhang, Li‐Jun Zhang, Xiao‐Lei Gong, Shi‐Bi Luo, Rong Zhao, Ruo‐Chuan Cheng   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells

Stem Cell Research & Therapy, 2017
Background Human dental mesenchymal stem cells (MSCs) are considered as highly accessible and attractive MSCs for use in regenerative medicine, yet some of their features are not as well characterized as other MSCs.
Victor G. Martinez, Imelda Ontoria-Oviedo, Carolina P. Ricardo, Sian E. Harding, Rosa Sacedon, Alberto Varas, Agustin Zapata, Pilar Sepulveda, Angeles Vicente   +8 more
doaj   +1 more source

An Enhanced Photothermal Therapeutic Iridium Hybrid Platform Reversing the Tumor Hypoxic Microenvironment

Molecules, 2022
As hypoxia is closely associated with tumor progression, proliferation, invasion, metastasis, and strong resistance to therapy, regulating and overcoming the hypoxia tumor microenvironment are two increasingly important aspects of tumor treatment. Herein,
Hang Zhang, Xiaoxiao Chen, Shengliang Li, Jianliang Shen, Zong-Wan Mao   +4 more
doaj   +1 more source