Results 1 to 10 of about 229,058 (209)

Hypoxia-inducible factor-1 alpha expression in endometriosis: A retrospective observational case–control study of ovarian cyst capsules and endometrial tissue samples [PDF]

Journal of International Medical Research
Background This study aimed to compare the expression patterns of hypoxia-inducible factor-1α in ovarian cyst capsules and endometrial tissue samples from patients with and without endometriosis to evaluate its potential as a biomarker of hypoxia in ...
Ezgi Tolu Cenk, Ceyda Sancakli Usta, Akin Usta, Gulay Turan, Gurhan Guney, Selim Afsar, Mine Islimye Taskin   +6 more
doaj   +2 more sources

Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Hypoxia-Inducible Factor-1 (HIF-1)-Active Cells as a Target for Cancer Therapy

Journal of Pharmacological Sciences, 2011
The microenvironment of solid tumors is characterized by low pO2 that is well below physiological levels. Intratumoral hypoxia is a major factor contributing to cancer progression and is exacerbated as a result of oxygen consumption by rapidly ...
Shinae Kizaka-Kondoh, Takahiro Kuchimaru, Tetsuya Kadonosono   +2 more
doaj   +3 more sources

Retraction: Induction of Hypoxia-inducible Factor 1 Activity by Muscarinic Acetylcholine Receptor Signaling. [PDF]

J Biol Chem
Hirota K, Fukuda R, Takabuchi S, Kizaka-Kondoh S, Adachi T, Fukuda K, Semenza GL.   +6 more
europepmc   +3 more sources

Hypoxia Inducible Factor-1α Attenuates Ischemic Brain Damage by Modulating Inflammatory Response and Glial Activity

Cells, 2021
Hypoxia-inducible factor 1 can sufficiently control the progress of neurological symptoms after ischemic stroke owing to their actions associated with its downstream genes.
Nashwa Amin, Shijia Chen, Qiannan Ren, Xiaoning Tan, Benson O. A. Botchway, Zhiying Hu, Fengpei Chen, Shan Ye, Xiaoxue Du, Zuobing Chen, Marong Fang   +10 more
doaj   +1 more source

Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis. [PDF]

PLoS ONE, 2017
Inflammation and hypoxia are hallmarks of inflammatory bowel disease. Low oxygen levels activate hypoxia-inducible factors as central transcriptional regulators of cellular responses to hypoxia, particularly in myeloid cells where hypoxia-inducible ...
Veronika Bäcker, Fung-Yi Cheung, Jens T Siveke, Joachim Fandrey, Sandra Winning   +4 more
doaj   +1 more source

Statement of Retraction: Knockdown of hypoxia-inducible factor 1-alpha (HIF1α) interferes with angiopoietin-like protein 2 (ANGPTL2) to attenuate high glucose-triggered hypoxia/reoxygenation injury in cardiomyocytes. [PDF]

Bioengineered
europepmc   +3 more sources

Basic Biology of Hypoxic Responses Mediated by the Transcription Factor HIFs and Its Implication for Medicine

Biomedicines, 2020
Oxygen (O2) is essential for human life. Molecular oxygen is vital for the production of adenosine triphosphate (ATP) in human cells. O2 deficiency leads to a reduction in the energy levels that are required to maintain biological functions.
Kiichi Hirota
doaj   +1 more source

Hypoxia-Inducible Factor 1 and Mitochondria: An Intimate Connection

Biomolecules, 2022
The general objective of the review is to explain the interaction between HIF-1 and mitochondria. On the one hand, this review describes the effects of HIF-1 on mitochondrial structure, including quantity, distribution, and morphology, as well as on ...
Xiaochen Huang, Li Zhao, Ruiyun Peng
doaj   +1 more source

Deterioration of alveolar development in mice with both HIF-3α knockout and HIF-2α knockdown

BMC Research Notes, 2018
Objective Earlier studies from our group using hypoxia-inducible factor 3α knockout mice showed impairments in lung remodeling and lung endothelial cells.
Firman Zulkifli Amin, Toshiharu Yamashita, Osamu Ohneda   +2 more
doaj   +1 more source

Research progress of HIF-1 mediated autophagy in cardiac diseases [PDF]

Jichu yixue yu linchuang, 2021
Hypoxia-inducible factor 1 (HIF-1) regulates the expression of target genes to keep the balance between oxygen supply and oxygen consumption, maintains oxygen homeostasis.
ZHANG Liu-jie, LI Jing, WU Bo
doaj