Results 41 to 50 of about 229,207 (357)
Tumor Biology, 2017 Many studies have analyzed the relationship between hypoxia inducible factor 1 alpha expression and its relation to differentiation, lymph node metastasis, and other clinicopathological variables of esophageal carcinoma, but the results are still ...
Shao Wu Jing, Jun Wang, Qing Xu
doaj +1 more source
Hypoxia, angiogenesis and atherogenesis [PDF]
, 2017 The balance between vascular oxygen supply and metabolic demand for oxygen within the vasculature is normally tightly regulated. An imbalance leads to hypoxia and a consequential cascade of cellular signals that attempt to offset the effects of hypoxia ...
Ferns, Gordon, Heikal, Lamia
core +2 more sources
Hypoxia-inducible factor-1 in tumour angiogenesis
World Journal of Gastroenterology, 2004 Hypoxia-inducible factor-1 (HIF-1), composed of HIF-alpha and HIF-beta subunits, is a heterodimeric transcriptional activator. In response to hypoxia, stimulation of growth factors, and activation of oncogenes as well as carcinogens, HIF-1alpha is overexpressed and/or activated and targets those genes which are required for angiogenesis, metabolic ...
Yong-Hong, Shi, Wei-Gang, Fang
openaire +2 more sources
Advanced Medical Journal, 2023 Background and objectives: Papillary thyroid carcinoma is one of the most common cancers of human, monocarbox- ylate transporter 1 and hypoxia inducible factor 1 alpha expressions in many tumors have recently being targets for treatment, HIF-1a has been
Hadeel Adnan Yasseen +1 more
doaj +1 more source
Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]
, 2018 Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat +3 more
core +1 more source
The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis: Figure 1 [PDF]
Journal of Clinical Pathology, 2004 Apoptosis can be induced in response to hypoxia. The severity of hypoxia determines whether cells become apoptotic or adapt to hypoxia and survive. A hypoxic environment devoid of nutrients prevents the cell undergoing energy dependent apoptosis and cells become necrotic. Apoptosis regulatory proteins are delicately balanced.
A E Greijer, E van der Wall
openaire +1 more source
Fifteen days of 3200m simulated hypoxia marginally regulates markers for protein synthesis and degradation in human skeletal muscle [PDF]
, 2016 Chronic hypoxia leads to muscle atrophy. The molecular mechanisms responsible for this phenomenon are not well defined in vivo. We sought to determine how chronic hypoxia regulates molecular markers of protein synthesis and degradation in human skeletal ...
Bertrand, L +7 more
core +2 more sources
Hypoxia‐inducible factor 1 and cancer pathogenesis [PDF]
IUBMB Life, 2008 AbstractHypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers as a result of genetic alterations and intratumoral hypoxia. HIF‐1 activates the transcription of genes that increase O2 availability by stimulating angiogenesis or that ...
openaire +2 more sources
Tumor Biology, 2017 Pancreatic ductal adenocarcinoma is one of the most lethal cancers. The Hippo pathway is involved in tumorigenesis and remodeling of tumor microenvironments.
Honglong Wei +6 more
doaj +1 more source
Kynurenine–PARP-1 Link Mediated by MicroRNA 210 May Be Dysregulated in Pulmonary Hypertension
Anatolian Journal of Cardiology, 2022 Background: Dysregulation of microRNAs is associated with pulmonary hypertension. The present study aimed to determine the alterations in microRNA and microRNA expressions and their role in signaling pathways and investigate the relationship with serum ...
Alperen Emre Akgun +4 more
doaj +1 more source