Results 51 to 60 of about 229,207 (357)

Pola MRNA Hypoxia Inducible Factor-1? (HIF-1?) Dan Exkspresi Protein HIF-1? Ginjal Tikus Pada Hipoksia Sistemik Kronik [PDF]

, 2012
Kspresiprotein HIF-1? pada organ ginjal dari tikus yang mengalamikondisi hipoksia secara sistemik menggunakan Hypoxic Chamber dengankadar O2 8% dan Nitrogen 92% dan kelompok kontrol pada kondisinormoksia. Pola mRNA HIF-1? dilihat berdasarkan hasil RT-PCR
Suciati, Y. (Yulia)
core  

Crucial involvement of xanthine oxidase in the intracellular signalling networks associated with human myeloid cell function [PDF]

, 2014
Xanthine oxidase (XOD) is an enzyme which plays a central role in purine catabolism by converting hypoxanthine into xanthine and then further into uric acid.
Abooali, Maryam, Coughlan, Karen, Gibbs, Bernhard F., Lall, Gurprit S., Lall, Harjinder S., Sumbayev, Vadim V.   +5 more
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Regulating cellular oxygen sensing by hydroxylation [PDF]

, 2017
Oxygen homeostasis under conditions of limited O2 supply requires hypoxia-dependent gene regulation. The transcription factor complex hypoxia-inducible factor 1 (HIF-1) has been recognized as the master regulator that mediates the adaptational genetic ...
Fandrey, Joachim, Gassmann, Max, Gorr, Thomas A.   +2 more
core  

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia [PDF]

, 2009
The transcription factor Hypoxia-inducible factor 1 (HIF-1) plays a central role in the transcriptional response to oxygen flux. To gain insight into the molecular pathways regulated by HIF-1, it is essential to identify the downstream-target genes.
Yair Benita, Hirotoshi Kikuchi, Andrew D. Smith, Michael Q. Zhang, Daniel C. Chung, Ramnik J. Xavier, Wang, Cockman, Ohh, Kamura, Tanimoto, Maxwell, Gustafsson, Jaakkola, Ivan, Wenger, Krishnamachary, Liao, Rankin, Raval, Kondo, Semenza, Patiar, Kim, Cho, Shen, Elvidge, Manalo, Zhou, Gupta, Zhu, Xie, Smith, Hestand, Cheung, Bulyk, Brown, Smith, Subramanian, Bussemaker, Conlon, Das, Barrett, Parkinson, Wu, Gentleman, Smyth, Benjamini, Karolchik, Schones, Kanehisa, Vastrik, Lewis, Wheeler, Mulder, Bairoch, Camon, Calvo, Mizukami, Mizukami, Chi, Denko, Gardner, Jin, Shoshani, Leonard, Takahashi, Wellmann, Jean, Barrera, Cid, Bourgeron, Li, Cockman, Li, Dreyfus, Nickols, Choi, Yan, Sigoillot, Lukowiak, Kollberg, Takaluoma, Beighton, Shan, Chen, Xenaki, Westenfelder, Forsythe, Pescador, Coulet, Hirao, Semenza, Fontanesi, Fukuda, Dimova, Choi, Sanchez-Elsner, Choi, Nardinocchi, Siepel   +100 more
core   +1 more source

Activation of Hypoxia-Inducible Factor-1 in Bacillary Angiomatosis [PDF]

Circulation, 2005
Background— Bartonella species are the only known bacterial pathogens causing vasculoproliferative disorders in humans (bacillary angiomatosis [BA]). Cellular and bacterial pathogenetic mechanisms underlying the induction of BA are largely unknown.
Volkhard A J, Kempf, Maria, Lebiedziejewski, Kari, Alitalo, Joo-Hee, Wälzlein, Urs, Ehehalt, Jeannette, Fiebig, Stephan, Huber, Burkhardt, Schütt, Christian A, Sander, Steffen, Müller, Guntram, Grassl, Amir S, Yazdi, Bernhard, Brehm, Ingo B, Autenrieth   +13 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Effect of low-frequency low-intensity ultrasound with microbubbles on prostate cancer hypoxia

Tumor Biology, 2017
Angiogenesis plays an important role in tumor growth, invasiveness, and metastasis. It is well established that prostate cancer is exposed to fluctuating oxygen tensions and both acute and chronic hypoxia exist, and these conditions can upregulate ...
Rui Hou, Yanjun Xu, Qijie Lu, Yang Zhang, Bing Hu   +4 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Interaction and Collaboration of SP1, HIF-1, and MYC in Regulating the Expression of Cancer-Related Genes to Further Enhance Anticancer Drug Development

Current Issues in Molecular Biology, 2023
Specificity protein 1 (SP1), hypoxia-inducible factor 1 (HIF-1), and MYC are important transcription factors (TFs). SP1, a constitutively expressed housekeeping gene, regulates diverse yet distinct biological activities; MYC is a master regulator of all ...
Kotohiko Kimura, Tiffany L. B. Jackson, Ru Chih C. Huang   +2 more
doaj   +1 more source