Results 31 to 40 of about 229,207 (357)
Neural Regeneration Research, 2021 Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains.
Qiu-Shi Gao +5 more
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Chest, 1998 Hypoxia-inducible factor 1 (HIF-1) mediates adaptive responses to hypoxia by activating the transcription of hundreds of target genes. The expression and activity of HIF-1 are oxygen-regulated, which provides a direct mechanism for transducing changes in cellular oxygenation to changes in gene expression.
Gregg L. Semenza +6 more
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HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
Biomedicines, 2021 Oxygen is essential for the maintenance of the body. Living organisms have evolved systems to secure an oxygen environment to be proper. Hypoxia-inducible factor (HIF) plays an essential role in this process; it is a transcription factor that mediates ...
Kiichi Hirota
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Haematologica, 2010 Background Multiple myeloma is an incurable malignancy of bone marrow plasma cells. Progression of multiple myeloma is accompanied by an increase in bone marrow angiogenesis.
Sally K. Martin +8 more
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The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]
, 2018 The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J +4 more
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Hypoxia inducible factor 1 (HIF-1) and cardioprotection [PDF]
Acta Pharmacologica Sinica, 2010 Since its discovery in early 1990s, hypoxia inducible factor 1 (HIF-1) has been increasingly recognized for its key role in transcriptional control of more than a hundred genes that regulate a wide-spectrum of cellular functional events, including angiogenesis, vasomotor control, glucose and energy metabolism, erythropoiesis, iron homeostasis, pH ...
Demet, Tekin, Ali D, Dursun, Lei, Xi
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Contribution of hypoxia inducible factor-1 during viral infections
Virulence, 2020 Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs ...
Antonia Reyes +5 more
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Hypoxia in atherogenesis [PDF]
, 2016 The anoxemia theory proposes that an imbalance between the demand for and supply of oxygen in the arterial wall is a key factor in the development of atherosclerosis.
Creemers EE +9 more
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Molecules, 2018 Induction of a series of anti-hypoxic proteins protects cells during exposure to hypoxic conditions. Hypoxia-inducible factor-α (HIF-α) is a major transcription factor that orchestrates this protective effect.
Shin-ichi Kawaguchi +11 more
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KDM2 family members are regulated by HIF-1 in hypoxia. [PDF]
, 2017 Hypoxia is not only a developmental cue but also a stress and pathological stimulus in many human diseases. The response to hypoxia at the cellular level relies on the activity of the transcription factor family, hypoxia inducible factor (HIF).
Batie, Michael +3 more
core +4 more sources