Results 31 to 40 of about 141,782 (118)
Hypoxia-inducible factor in breast cancer: role and target for breast cancer treatment
Frontiers in ImmunologyGlobally, breast cancer stands as the most prevalent form of cancer among women. The tumor microenvironment of breast cancer often exhibits hypoxia. Hypoxia-inducible factor 1-alpha, a transcription factor, is found to be overexpressed and activated in ...
Shijiao Zhi +5 more
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Hypoxia-Inducible Factor 1-Related Diseases and Prospective Therapeutic Tools
Journal of Pharmacological Sciences, 2004 Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. HIF-1 regulates the expressions of the proteins that increase oxygen delivery, which enables cells to survive in oxygen-deficient ...
Jong-Wan Park +2 more
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Antioxidants, 2017 The importance of the tumor microenvironment for cancer progression and therapeutic resistance is an emerging focus of cancer biology. Hypoxia, or low oxygen, is a hallmark of solid tumors that promotes metastasis and represents a significant obstacle to
Rachel K. Toth, Noel A. Warfel
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Hypoxia-Inducible Factor 1 Protects Hypoxic Astrocytes against Glutamate Toxicity
ASN Neuro, 2012 Stroke is a major neurological disorder characterized by an increase in the Glu (glutamate) concentration resulting in excitotoxicity and eventually cellular damage and death in the brain. HIF-1 (hypoxia-inducible factor-1), a transcription factor, plays
Yomna Badawi +2 more
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Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2013 Background and Objectives: Cadmium is one of the most important biological contaminants that its intake in pregnancy causes disease and malformation s in the mother and baby.
Shadmehr Mirdar +3 more
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Radiolabeled Probes Targeting Hypoxia-Inducible Factor-1-Active Tumor Microenvironments
The Scientific World Journal, 2014 Because tumor cells grow rapidly and randomly, hypoxic regions arise from the lack of oxygen supply in solid tumors. Hypoxic regions in tumors are known to be resistant to chemotherapy and radiotherapy.
Masashi Ueda, Hideo Saji
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Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses
Frontiers in Immunology, 2018 Low oxygen environments and accumulation of hypoxia-inducible factors (HIFs) are features of infected and inflamed tissues. Here, we summarize our current knowledge on oxygen levels found in Leishmania-infected tissues and discuss which mechanisms ...
Valentin Schatz +3 more
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Hypoxia-inducible factor 1α inhibitor reduces hippocampal neuronal ferroptosis
Neural Regeneration ResearchEpilepsy is a prevalent neurological disorder in which hippocampal neuronal damage, particularly ferroptosis, plays a critical role. Previous studies have shown that hypoxia-inducible factor 1α is considered an important regulator of cellular stress ...
Zhen Liang +5 more
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Oxygen – the forgotten nutrient
Journal of Nutritional Science, 2017 O2 is essential for the maintenance and growth of aerobic animals, similar to the essentiality of what are classically considered nutrients. Nevertheless, O2 is not customarily regarded as a nutrient, this reflecting the route by which it enters the body
Paul Trayhurn
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In Vitro Investigation of HIF-1α as a Therapeutic Target for Thyroid-Associated Ophthalmopathy [PDF]
Endocrinology and MetabolismBackground Thyroid-associated ophthalmopathy (TAO) involves tissue expansion and inflammation, potentially causing a hypoxic microenvironment. Hypoxia-inducible factor (HIF)-1α is crucial in fibrosis and adipogenesis, which are observed in TAO ...
Jeongmin Lee +9 more
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