Results 21 to 30 of about 229,207 (357)
Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells [PDF]
, 2014 BACKGROUND: Metastatic triple-negative breast cancer is mostly incurable, due to lack of suitable drug targets. The insulin-like growth factor (IGF) system could provide such a target, and IGF-1 receptor (IGF-1R)-directed agents are already available ...
Bonzi, M.C. +6 more
core +2 more sources
Interaction des virus avec la voie cellulaire de réponse à l’hypoxie [PDF]
, 2005 Des travaux récents réalisés in vitro montrent que l’appauvrissement du milieu de culture en oxygène (hypoxie) active la réplication du parvovirus humain B19, des virus du sarcome de Kaposi et de l’immunodéficience humaine, ainsi que l’expression de ...
Le Guyader, Nathalie, Pillet, Sylvie
core +1 more source
Hypoxia-inducible factor-1 and neuroglobin expression [PDF]
Neuroscience Letters, 2012 Neuroglobin (Ngb) is a hypoxia-inducible protein with cytoprotective effects in animal models of stroke, Alzheimer's disease, and related disorders, but the molecular mechanisms involved in its induction are unknown. We tested the hypothesis that hypoxia-inducible factor-1 (HIF-1) regulates Ngb levels, using shRNA-mediated knockdown and lentiviral ...
Bryan, Haines +6 more
openaire +2 more sources
Molecular Pain, 2019 Chemotherapy-induced painful peripheral neuropathy is a significant clinical problem that is associated with widely used chemotherapeutics. Unfortunately, the molecular mechanisms by which chemotherapy-induced painful peripheral neuropathy develops have ...
Taylor Ludman, Ohannes K Melemedjian
doaj +1 more source
Genipin Inhibits Hypoxia-Induced Accumulation of HIF-1α and VEGF Expressions in Human Cervical Carcinoma Cells [PDF]
Kosin Medical Journal, 2019 Objectives Hypoxia—a characteristic of almost all types of solid tumors—has been associated with poor outcomes in several human malignancies. Genipin—an active constituent of Gardenia fruit— has been reported to exert an anti-tumor effect in several ...
Cho Eui Jin +3 more
doaj +1 more source
Neural Regeneration Research, 2022 [INLINE:1] Obstructive sleep apnea can worsen the prognosis of subarachnoid hemorrhage. However, the underlying mechanism remains unclear. In this study, we established a mouse model of subarachnoid hemorrhage using the endovascular perforation method ...
Jun Xu +8 more
doaj +1 more source
Identification of small molecule compounds that inhibit the HIF-1 signaling pathway [PDF]
, 2009 Background Hypoxia-inducible factor-1 (HIF-1) is the major hypoxia-regulated transcription factor that regulates cellular responses to low oxygen environments.
Sun Yi +10 more
core +2 more sources
Haematologica, 2012 Background Iron metabolism, regulated by the iron hormone hepcidin, and oxygen homeostasis, dependent on hypoxia-inducible factors, are strongly interconnected.
Maria Mastrogiannaki +6 more
doaj +1 more source
Multiple roles of hypoxia in ovarian function: roles of hypoxia-inducible factor-related and -unrelated signals during the luteal phase [PDF]
, 2015 There is increasing interest in the role of oxygen conditions in the microenvironment of organs because of the discovery of a hypoxia-specific transcription factor, namely hypoxia-inducible factor (HIF) 1.
Nishimura, Ryo, Okuda, Kiyoshi
core +1 more source
Tumor Biology, 2017 Hypoxia plays a critical role in the progression and metastasis of hepatocellular carcinoma by activating the key transcription factor, hypoxia-inducible factor-1.
Ming Ye +11 more
doaj +1 more source