Results 1 to 10 of about 480,886 (266)
Sestrin2 in hypoxia and hypoxia-related diseases [PDF]
Redox Report, 2021 Objectives: Sestrin2 is a stress-inducible protein and play an important role in adapting stress states of cells. This article reviewed the role of Sestrin2 in hypoxia and hypoxia-related diseases to provide new perspectives for future research and new therapeutic targets for hypoxia-related diseases.Methods: A review was conducted through an ...
Xiaojing Che +7 more
openaire +3 more sources
HYPOXIA AND REPRODUCTIVE HEALTH: Hypoxia and labour [PDF]
Reproduction, 2021 Abstract Intermittent myometrial hypoxia is a normal feature of labour, as the powerful contractions compress blood vessels. In this review, we focus on the relation between hypoxia, myometrial metabolism, and contractility. We dissect how hypoxia can feedback and limit an ongoing contraction and help prevent foetal distress.
Susan, Wray +2 more
openaire +2 more sources
Contribution of collagen XIII to lung function and development of pulmonary fibrosis
BMJ Open Respiratory Research, 2023 Background Collagen XIII is a transmembrane collagen associated with neuromuscular junction development, and in humans its deficiency results in congenital myasthenic syndrome type 19 (CMS19), which leads to breathing difficulties. CMS19 patients usually
Riitta Kaarteenaho +7 more
doaj +1 more source
Hypoxia-Induced Suppression of Antiapoptotic Bcl-2 Expression in Human Bladder Tumor Cells Is Regulated by Caveolin-1-Dependent Adenosine Monophosphate-Activated Protein Kinase Activity [PDF]
International Neurourology Journal, 2021 Purpose Adenosine monophosphate-activated protein kinase (AMPK) is thought to inhibit cell proliferation or promote cell death, but the details remain unclear.
Tae Jin Cho +4 more
doaj +1 more source
Stem Cell Research, 2021 Transcription factors TEAD1 and TEAD4 play an important role in development, differentiation, cell growth and proliferation. To further understand the exact role of TEAD1 and TEAD4 in these processes.
Yingyi Quan +11 more
doaj +1 more source
Hypoxia and Hypoxia-Inducible Factors in Lymphedema
Frontiers in Pharmacology, 2022 Lymphedema is a chronic inflammatory disorder characterized by edema, fat deposition, and fibrotic tissue remodeling. Despite significant advances in lymphatic biology research, our knowledge of lymphedema pathology is incomplete. Currently, there is no approved pharmacological therapy for this debilitating disease.
Xinguo Jiang +13 more
openaire +3 more sources
Abdominal Aortic Occlusion and the Inflammatory Effects in Heart and Brain
Mediators of Inflammation, 2023 Background. Abdominal aortic occlusion (AAO) occurs frequently and causes ischemia/reperfusion (I/R) injury to distant organs. In this study, we aimed to investigate whether AAO induced I/R injury and subsequent damage in cardiac and neurologic tissue ...
Jun Xu +9 more
doaj +1 more source
Hypoxia and Hypoxia-Inducible Factors in Leukemias [PDF]
Frontiers in Oncology, 2016 Despite huge improvements in the treatment of leukemia, the percentage of patients suffering relapse still remains significant. Relapse most often results from a small number of leukemic stem cells (LSCs) within the bone marrow, which are able to self-renew, and therefore reestablish the full tumor.
Margaux eDeynoux +4 more
openaire +3 more sources
Hypoxia in Atherogenesis [PDF]
Angiology, 2016 The anoxemia theory proposes that an imbalance between the demand for and supply of oxygen in the arterial wall is a key factor in the development of atherosclerosis. There is now substantial evidence that there are regions within the atherosclerotic plaque in which profound hypoxia exists; this may fundamentally change the function, metabolism, and ...
Ferns, Gordon A A, Heikal, Lamia
openaire +2 more sources
Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function [PDF]
Arthritis Research & Therapy, 2009 With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation is key to the development of novel therapies.
Walmsley, SR, Chilvers, ER, Whyte, MKB
openaire +4 more sources