Results 1 to 10 of about 642,296 (308)
Experimental Models of Sarcopenia: Bridging Molecular Mechanism and Therapeutic Strategy
Cells, 2020 Sarcopenia has been defined as a progressive decline of skeletal muscle mass, strength, and functions in elderly people. It is accompanied by physical frailty, functional disability, falls, hospitalization, and mortality, and is becoming a major ...
Sakulrat Mankhong +5 more
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Controls of Nuclear Factor-Kappa B Signaling Activity by 5’-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells [PDF]
International Neurourology Journal, 2016 Generally, both lipopolysaccharide (LPS)- and hypoxia-induced nuclear factor kappa B (NF-κB) effects are alleviated through differential posttranslational modification of NF-κB phosphorylation after pretreatment with 5´-AMP-activated protein kinase (AMPK)
Bo-Hwa Choi +4 more
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Biomolecules, 2022 Neurogenesis plays an important role in the prognosis of stroke patients and is known to be promoted by the activation of the Notch1 signaling pathway. Studies on the airway epithelium have shown that miR-449b represses the Notch pathway. The study aimed
Sijie Li +11 more
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Cardiovascular TherapeuticsConclusions: Verteporfin protects the heart against ISO-induced myocardial hypertrophy by regulating IL-6/STAT3 in cardiac fibroblasts.
Sunpeng Sheng +8 more
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BiomoleculesCerebrovascular diseases (CVDs), comprising predominantly ischemic stroke and chronic cerebral hypoperfusion (CCH), are a significant threat to global health, often leading to disability and mortality.
Linhui Qin +3 more
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Life, 2022 Several publications and random observations have reported weight loss in high-altitude sojourners of both sexes. This could be a result of multiple adaptations, which hypoxia and mountaineering provoke on a cellular and organic level.
Stephan Pramsohler +3 more
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Neoplasia: An International Journal for Oncology Research, 2022 Regions of low oxygen (hypoxia) are found in >50% of breast tumours, most frequently in the more aggressive triple negative breast cancer subtype (TNBC). Metastasis is the cause of 90% of breast cancer patient deaths. Regions of tumour hypoxia tend to be
Christopher Paul Carroll +8 more
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Metabolic and hypoxic adaptation to anti‐angiogenic therapy: a target for induced essentiality
EMBO Molecular Medicine, 2015 Anti‐angiogenic therapy has increased the progression‐free survival of many cancer patients but has had little effect on overall survival, even in colon cancer (average 6–8 weeks) due to resistance.
Alan McIntyre, Adrian L Harris
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Open Life Sciences, 2023 Curcumin is the most abundant derivative of turmeric rhizome. Although studies have proved that curcumin could inhibit the growth of tumors, its specific molecular mechanism has not yet been fully elucidated.
Wang Xiaoping +4 more
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Collagens Regulating Adipose Tissue Formation and Functions
Biomedicines, 2023 The globally increasing prevalence of obesity is associated with the development of metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver.
Iida Jääskeläinen +6 more
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