Results 21 to 30 of about 662,957 (307)
Hypoxia and hypoxia-inducible factors in neuroblastoma [PDF]
Cell and Tissue Research, 2017 Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2.
Påhlman, Sven, Mohlin, Sofie
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Clinical Cancer Research, 2007 In this issue of Clinical Cancer Research , Rofstad et al. ([1][1]) report on the significance of chronic (diffusion-limited) and acute (fluctuating or perfusion-limited) hypoxia in D-12 and R-18 human melanoma xenografts on the development of metastatic disease.
Naz, Chaudary, Richard P, Hill
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Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]
, 2014 Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival ...
Biddlestone, John +4 more
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Pulmonary Circulation, 2020 In some subjects, high-altitude hypobaric hypoxia leads to high-altitude pulmonary hypertension. The threshold for the diagnosis of high-altitude pulmonary hypertension is a mean pulmonary artery pressure of 30 mmHg, even though for general pulmonary ...
Julio Brito +2 more
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The Somatotropic Axis in the Sleep Apnea-Obesity Comorbid Duo
Frontiers in Endocrinology, 2020 Background: Growth hormone (GH) stimulates the production of insulin-like growth factor 1 (IGF-1) in most tissues and together GH and IGF-1 profoundly impact adipose tissue deposition, glucose metabolism and cardiovascular function.
Louis-Marie Galerneau +8 more
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Frontiers in Oncology, 2022 Integrin α11β1 is a collagen-binding integrin that is needed to induce and maintain the myofibroblast phenotype in fibrotic tissues and during wound healing.
Guillermo A. Martínez-Nieto +20 more
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Frontiers in Immunology, 2022 Chronic ethanol abuse is a systemic disorder and a risk factor for acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). However, the mechanisms involved are unknown.
Wenhua Sang +6 more
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Hypoxia-induced alternative splicing in endothelial cells [PDF]
, 2012 Background: Adaptation to low oxygen by changing gene expression is vitally important for cell survival and tissue development. The sprouting of new blood vessels, initiated from endothelial cells, restores the oxygen supply of ischemic tissues.
Weigand, Julia E. +15 more
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Oxydative stress in type 2 diabetic patients: involvement of HIF-1 alpha AND mTOR genes expression [PDF]
The Ukrainian Biochemical Journal, 2023 Biochemical and genetic mechanisms of oxidative stress (OS) developing in the blood of patients with type 2 Diabetes mellitus (T2DM) were studied. Twenty patients with T2DM and 10 healthy persons participated in this study.
Y. A. Saenko +5 more
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Seminars in Cell & Developmental Biology, 2005 To understand how cells respond to altered oxygenation, a frequent experimental paradigm is to isolate known components of bona fide oxygen responsive proteins. Recent studies have shown that a protein known as CSN5 or JAB1 interacts with both the HIF-1alpha oxygen-responsive transcription factor and its oxygen-dependent regulator, the Von Hippel ...
Peter, Mikus, Wayne, Zundel
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