Results 21 to 30 of about 1,127,805 (351)
HYPOXIA AND REPRODUCTIVE HEALTH: Hypoxia and labour [PDF]
Reproduction, 2021 Intermittent myometrial hypoxia is a normal feature of labour, as the powerful contractions compress blood vessels. In this review, we focus on the relation between hypoxia, myometrial metabolism, and contractility. We dissect how hypoxia can feedback and limit an ongoing contraction and help prevent foetal distress.
Susan, Wray +2 more
openaire +2 more sources
Stem Cell Research, 2021 VGLL4 is a new component of the Hippo pathway and bind TEADs to compete with YAP, so as to inhibit tumor progression, but its role in stem cell and organ regeneration remains unclear. Using the PiggyBac transposon system, we generated a VGLL4 doxycycline-
Yingyi Quan +11 more
doaj +1 more source
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Signal Transduction and Targeted Therapy, 2023 Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic species and plays a prominent role in cardiovascular diseases.
Yongchao Zhao +9 more
semanticscholar +1 more source
STAR Protocols, 2022 Summary: In human pluripotent stem cells (hPSCs), traditional approaches for gene overexpression have low efficiency and are often laborious. Here, we provide a relatively simple protocol for gene overexpression with the Dox-inducible PiggyBac transposon
Jiwen Yang, Minjie Hu, Yongyu Wang
doaj +1 more source
Stem Cell Research, 2020 A human induced pluripotent stem cell (hiPSC) line (WMUi001-A) was generated from the aortic tissue of a 47-year-old donor with aortic dissection and normal blood pressure.
Peifeng Jin +14 more
doaj +1 more source
Cancer Cell International, 2021 Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels supplying the tumor.
Asieh Emami Nejad +12 more
semanticscholar +1 more source
Life, 2023 Background: Athletes often experience poor sleep quality due to stress, altitude exposure, travel across different time zones, and pre-competition nervousness.
Felix Willmer +5 more
doaj +1 more source
Hypoxia and hypoxia-inducible factors in diabetes and its complications
Diabetologia, 2021 Hypoxia-inducible factors (HIFs) are the key regulators of oxygen homeostasis in response to hypoxia. In diabetes, multiple tissues are hypoxic but adaptive responses to hypoxia are impaired due to insufficient activation of HIF signalling, which results
S. Catrina, Xiaowei Zheng
semanticscholar +1 more source
International Journal of Molecular Sciences, 2021 Chronic (continuous, non-interrupted) hypoxia and cycling (intermittent, transient) hypoxia are two types of hypoxia occurring in malignant tumors. They are both associated with the activation of hypoxia-inducible factor-1 (HIF-1) and nuclear factor κB ...
J. Korbecki +6 more
semanticscholar +1 more source
The CMS19 disease model specifies a pivotal role for collagen XIII in bone homeostasis
Scientific Reports, 2022 Mutations in the COL13A1 gene result in congenital myasthenic syndrome type 19 (CMS19), a disease of neuromuscular synapses and including various skeletal manifestations, particularly facial dysmorphisms. The phenotypic consequences in Col13a1 null mice (
A. V. Kemppainen +8 more
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