Results 41 to 50 of about 592,371 (315)

Biology of Hypoxia [PDF]

Seminars in Nuclear Medicine, 2015
There is an important and strong, but complex influence of the tumor microenvironment on tumor cells' phenotype, aggressiveness, and treatment sensitivity. One of the most frequent and best-studied aspects of the tumor microenvironment is hypoxia. Low oxygen tension often occurs in tumor cells by several mechanisms, for example, poor angiogenesis and ...
Span, P.N., Span, P.N., Bussink, J.
openaire   +3 more sources

Dual role of the L-arginine–ADMA–NO pathway in systemic hypoxic vasodilation and pulmonary hypoxic vasoconstriction

Pulmonary Circulation, 2020
In healthy vascular endothelium, nitric oxide acts as a vasodilator paracrine mediator on adjacent smooth muscle cells. By activating soluble guanylyl cyclase, nitric oxide stimulates cyclic guanosine monophosphate (cGMP) which causes relaxation of ...
Rainer Böger, Juliane Hannemann
doaj   +1 more source

Controls of Nuclear Factor-Kappa B Signaling Activity by 5’-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells [PDF]

International Neurourology Journal, 2016
Generally, both lipopolysaccharide (LPS)- and hypoxia-induced nuclear factor kappa B (NF-κB) effects are alleviated through differential posttranslational modification of NF-κB phosphorylation after pretreatment with 5´-AMP-activated protein kinase (AMPK)
Bo-Hwa Choi, Da-Hyun Lee, Jin Kim, Ju-Hee Kang, Chang-Shin Park   +4 more
doaj   +1 more source

Experimental Models of Sarcopenia: Bridging Molecular Mechanism and Therapeutic Strategy

Cells, 2020
Sarcopenia has been defined as a progressive decline of skeletal muscle mass, strength, and functions in elderly people. It is accompanied by physical frailty, functional disability, falls, hospitalization, and mortality, and is becoming a major ...
Sakulrat Mankhong, Sujin Kim, Sohee Moon, Hyo-Bum Kwak, Dong-Ho Park, Ju-Hee Kang   +5 more
doaj   +1 more source

Limb Remote Ischemic Conditioning Promotes Neurogenesis after Cerebral Ischemia by Modulating miR-449b/Notch1 Pathway in Mice

Biomolecules, 2022
Neurogenesis plays an important role in the prognosis of stroke patients and is known to be promoted by the activation of the Notch1 signaling pathway. Studies on the airway epithelium have shown that miR-449b represses the Notch pathway. The study aimed
Sijie Li, Yong Yang, Ning Li, Haiyan Li, Jiali Xu, Wenbo Zhao, Xiaojie Wang, Linqing Ma, Chen Gao, Yuchuan Ding, Xunming Ji, Changhong Ren   +11 more
doaj   +1 more source

Inspiratory muscle training and its effect on indices of physiological and perceived stress during incremental walking exercise in normobaric hypoxia

, 2014
This study evaluated the effects of inspiratory muscle training (IMT) on inspiratory muscle fatigue (IMF) and physiological and perceptual responses during trekking-specific exercise. An 8-week IMT program was completed by 21 males (age 32.4 – 9.61 years,
MALACRIDA S, BARTESAGHI M, Seims, A, Cooke, CB, MILLINO, CATERINA, O'Hara, J, PRATALI L, LAVEDER, PAOLO, CELEGATO, BARBARA, King, R, GIARDINI G, PACCHIONI, BENIAMINA, LANFRANCHI, GEROLAMO   +12 more
core   +1 more source

Modeling Thoracic Aortic Dissection Using Patient-Specific iPSCs Reveals VSMC Dysfunction and Extracellular Matrix Dysregulation

Stem Cells International
Thoracic aortic dissection (TAD) is a life-threatening condition characterized by medial degeneration and vascular smooth muscle cell (VSMC) dysfunction, with no effective medical therapy currently available. The underlying pathological mechanisms of TAD
Peifeng Jin, Yubin Xu, Sixian Wang, Lu Ding, Yuhao Chen, Miqi Zhou, Xiufang Chen, Xiaofang Fan, Yongsheng Gong, Ming Li, Yongyu Wang   +10 more
doaj   +1 more source

Decline of erythropoietin formation at continuous hypoxia is not due to feedback inhibition [PDF]

, 1990
Serum erythropoietin (EPO) levels in response to hypoxia are known to decline before an increase in blood oxygen carrying capacity. To define the possible mechanisms underlying this phenomenon, we have investigated 1) how renal EPO mRNA content and EPO ...
J. Dittmer, Neumann, R., Eckardt, K. U., Bauer, C., A. Kurtz, Christian Bauer, Dittmer, J., Armin Kurtz, Jurgen Dittmer, K. U. Eckardt, Kai-uwe Eckardt, Kurtz, Armin, R. Neumann, C. Bauer, Rainer Neumann   +14 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Verteporfin Mitigates Isoproterenol-Induced Myocardial Hypertrophy by Attenuating IL-6/STAT3 in Cardiac Fibroblasts

Cardiovascular Therapeutics
Conclusions: Verteporfin protects the heart against ISO-induced myocardial hypertrophy by regulating IL-6/STAT3 in cardiac fibroblasts.
Sunpeng Sheng, Lu Ding, Jinbiao Lai, Zelei Ye, Ru Zhao, Shijia Chen, Jianshe Ma, Junming Fan, Peifeng Jin   +8 more
doaj   +1 more source