Results 51 to 60 of about 642,296 (308)

Modeling Thoracic Aortic Dissection Using Patient-Specific iPSCs Reveals VSMC Dysfunction and Extracellular Matrix Dysregulation

Stem Cells International
Thoracic aortic dissection (TAD) is a life-threatening condition characterized by medial degeneration and vascular smooth muscle cell (VSMC) dysfunction, with no effective medical therapy currently available. The underlying pathological mechanisms of TAD
Peifeng Jin, Yubin Xu, Sixian Wang, Lu Ding, Yuhao Chen, Miqi Zhou, Xiufang Chen, Xiaofang Fan, Yongsheng Gong, Ming Li, Yongyu Wang   +10 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Dose-dependent effects of Allopurinol on human foreskin fibroblast cell and human umbilical vein endothelial cell under hypoxia [PDF]

, 2015
Allopurinol, an inhibitor of xanthine oxidase, has been used in clinical trials of patients with cardiovascular and chronic kidney disease. These are two pathologies with extensive links to hypoxia and activation of the transcription factor hypoxia ...
Sun, Yu, George Jacob, Sun Yu, Yu Sun, Sonia Rocha, Jacob George, George, Jacob, Rocha, Sonia, Rocha Sonia   +8 more
core   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens [PDF]

, 2010
Background: Hypoxia inducible factor (HIF)-1 is the key transcriptional factor involved in the adaptation process of cells and organisms to hypoxia. Recent findings suggest that HIF-1 plays also a crucial role in inflammatory and infectious diseases ...
Peschel, Andreas, Edelmann, Markus, Schäfer, Andrea, Werth Nadine, Andreas Peschel, Volkhard A. J. Kempf, Edelmann Markus, Yazdi Amir S., Becker, Karsten, Rosenberger, Christian, Nadine Werth, Amir S Yazdi, Volkhard A J Kempf, Bernhardt Wanja, Kempf, Volkhard A. J., Amr, Amro, Rosenberger Christian, Amr Amro, Werth, Nadine, Andrea Schäfer, Peschel Andreas, von Eiff Christof, Christiane Beerlage, Kempf Volkhard A. J., Eiff, Christof von, Amro Amr, Becker Karsten, Beerlage, Christiane, Christof von Eiff, Wanja Bernhardt, Yazdi, Amir Sadegh, Bernhardt, Wanja, Christian Rosenberger, Karsten Becker, Schäfer Andrea, Beerlage Christiane, Amir S. Yazdi, Markus Edelmann   +37 more
core   +2 more sources

Hypoxia-Inducible Factors [PDF]

, 2022
Oxygen is an essential molecule in the production of adenosine triphosphate (ATP) in cells, and a lack of energy due to O2 deficiency makes the maintenance of biological functions and human life improbable.

core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Blood rheology adjustments in rats after a program of intermittent exposure to hypobaric hypoxia [PDF]

, 2013
Esteva, Santiago, Pere Panisello, Joan Ramon Torrella, Teresa Pagés, and Ginés Viscor. Blood rheology adjustments in rats after a program of intermittent exposure to hypobaric hypoxia. High Alt. Med. Biol. 10:275-281, 2009. Intermittent hypobaric hypoxia
Esteva i Gras, Santiago, Panisello Tafalla, Pere, Torrella Guio, Joan Ramon, Pagés, Teresa, Viscor Carrasco, Ginés   +4 more
core   +1 more source

Hypoxia. 3. Hypoxia and neurotransmitter synthesis

American Journal of Physiology-Cell Physiology, 2011
Central and peripheral neurons as well as neuroendocrine cells express a variety of neurotransmitters/modulators that play critical roles in regulation of physiological systems. The synthesis of several neurotransmitters/modulators is regulated by O2-requiring rate-limiting enzymes.
openaire   +3 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source