Results 11 to 20 of about 480,886 (266)
Journal of Molecular Medicine, 2007 A major feature of solid tumours is hypoxia, decreased availability of oxygen, which increases patient treatment resistance and favours tumour progression. How hypoxic conditions are generated in tumour tissues and how cells respond to hypoxia are essential questions in understanding tumour progression and metastasis.
Brahimi-Horn, M Christiane +2 more
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Stem Cell Research, 2021 VGLL4 is a new component of the Hippo pathway and bind TEADs to compete with YAP, so as to inhibit tumor progression, but its role in stem cell and organ regeneration remains unclear. Using the PiggyBac transposon system, we generated a VGLL4 doxycycline-
Yingyi Quan +11 more
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Stem Cell Research, 2020 A human induced pluripotent stem cell (hiPSC) line (WMUi001-A) was generated from the aortic tissue of a 47-year-old donor with aortic dissection and normal blood pressure.
Peifeng Jin +14 more
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Hypoxia and Inflammation [PDF]
New England Journal of Medicine, 2011 This review deals with emerging evidence of an association between systemic or local hypoxia and inflammation in a variety of diseases. The evidence points to new ways of treating inflammatory disorders or conditions such as certain cancers with intralesional hypoxia.
Holger K, Eltzschig, Peter, Carmeliet
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STAR Protocols, 2022 Summary: In human pluripotent stem cells (hPSCs), traditional approaches for gene overexpression have low efficiency and are often laborious. Here, we provide a relatively simple protocol for gene overexpression with the Dox-inducible PiggyBac transposon
Jiwen Yang, Minjie Hu, Yongyu Wang
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Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis [PDF]
Arthritis Research & Therapy, 2009 Autoimmunity, microangiopathy and tissue fibrosis are hallmarks of systemic sclerosis (SSc). Vascular alterations and reduced capillary density decrease blood flow and impair tissue oxygenation in SSc. Oxygen supply is further reduced by accumulation of extracellular matrix (ECM), which increases diffusion distances from blood vessels to cells ...
Beyer, C +4 more
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Hypoxia and hypoxia-inducible factors in neuroblastoma [PDF]
Cell and Tissue Research, 2017 Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2.
Påhlman, Sven, Mohlin, Sofie
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Life, 2023 Background: Athletes often experience poor sleep quality due to stress, altitude exposure, travel across different time zones, and pre-competition nervousness.
Felix Willmer +5 more
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Clinical Cancer Research, 2007 In this issue of Clinical Cancer Research , Rofstad et al. ([1][1]) report on the significance of chronic (diffusion-limited) and acute (fluctuating or perfusion-limited) hypoxia in D-12 and R-18 human melanoma xenografts on the development of metastatic disease.
Naz, Chaudary, Richard P, Hill
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The CMS19 disease model specifies a pivotal role for collagen XIII in bone homeostasis
Scientific Reports, 2022 Mutations in the COL13A1 gene result in congenital myasthenic syndrome type 19 (CMS19), a disease of neuromuscular synapses and including various skeletal manifestations, particularly facial dysmorphisms. The phenotypic consequences in Col13a1 null mice (
A. V. Kemppainen +8 more
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