Results 1 to 10 of about 5,403,999 (308)

Chromodomain helicase DNA-binding proteins and orofacial cleft [PDF]

Journal of Research in Medical Sciences
Orofacial clefts (OFCs) are among the most common congenital anomalies, arising from a complex interplay of genetic and environmental factors that disrupt the precisely coordinated processes of craniofacial development.
Mehran Dehghanian, Majid Hosseinzadeh, Hossein Abdali, Nayereh Nouri, Mohammad Kazemi   +4 more
doaj   +2 more sources

DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins [PDF]

Nature Communications
Single-stranded DNA-binding proteins (SSBs) protect transiently exposed ssDNA, yet how DNA polymerase (DNAp) displaces them during replication remains unclear.
Longfu Xu, Shikai Jin, Mia Urem, Seung-Joo Lee, Meindert H. Lamers, Xun Chen, Peter G. Wolynes, Gijs J. L. Wuite   +7 more
doaj   +3 more sources

Blood Plasma Exosomes Contain Circulating DNA in Their Crown

Diagnostics, 2022
It is known that circulating DNA (cirDNA) is protected from nuclease activity by proteins that form macromolecular complexes with DNA. In addition, it was previously shown that cirDNA can bind to the outer surface of exosomes.
Oleg Tutanov, Tatiana Shtam, Alina Grigor’eva, Alexey Tupikin, Yuri Tsentalovich, Svetlana Tamkovich   +5 more
doaj   +1 more source

Single-Molecule Microscopy Meets Molecular Dynamics Simulations for Characterizing the Molecular Action of Proteins on DNA and in Liquid Condensates

Frontiers in Molecular Biosciences, 2021
DNA-binding proteins trigger various cellular functions and determine cellular fate. Before performing functions such as transcription, DNA repair, and DNA recombination, DNA-binding proteins need to search for and bind to their target sites in genomic ...
Kiyoto Kamagata
doaj   +1 more source

Prediction of DNA-Binding Protein–Drug-Binding Sites Using Residue Interaction Networks and Sequence Feature

Frontiers in Bioengineering and Biotechnology, 2022
Identification of protein–ligand binding sites plays a critical role in drug discovery. However, there is still a lack of targeted drug prediction for DNA-binding proteins. This study aims at the binding sites of DNA-binding proteins and drugs, by mining
Wei Wang, Wei Wang, Yu Zhang, Dong Liu, Dong Liu, HongJun Zhang, XianFang Wang, Yun Zhou   +7 more
doaj   +1 more source

Sliding of proteins non-specifically bound to DNA: Brownian dynamics studies with coarse-grained protein and DNA models. [PDF]

PLoS Computational Biology, 2014
DNA binding proteins efficiently search for their cognitive sites on long genomic DNA by combining 3D diffusion and 1D diffusion (sliding) along the DNA.
Tadashi Ando, Jeffrey Skolnick
doaj   +1 more source

21 Fluorescent Protein-Based DNA Staining Dyes

Molecules, 2022
Fluorescent protein–DNA-binding peptides or proteins (FP-DBP) are a powerful means to stain and visualize large DNA molecules on a fluorescence microscope.
Yurie Tehee Kim, Hyesoo Oh, Myung Jun Seo, Dong Hyeun Lee, Jieun Shin, Serang Bong, Sujeong Heo, Natalia Diyah Hapsari, Kyubong Jo   +8 more
doaj   +1 more source

Predicting target DNA sequences of DNA-binding proteins based on unbound structures. [PDF]

PLoS ONE, 2012
DNA-binding proteins such as transcription factors use DNA-binding domains (DBDs) to bind to specific sequences in the genome to initiate many important biological functions.
Chien-Yu Chen, Ting-Ying Chien, Chih-Kang Lin, Chih-Wei Lin, Yi-Zhong Weng, Darby Tien-Hao Chang   +5 more
doaj   +1 more source

Analysis and prediction of single-stranded and double-stranded DNA binding proteins based on protein sequences

BMC Bioinformatics, 2017
Background DNA-binding proteins perform important functions in a great number of biological activities. DNA-binding proteins can interact with ssDNA (single-stranded DNA) or dsDNA (double-stranded DNA), and DNA-binding proteins can be categorized as ...
Wei Wang, Lin Sun, Shiguang Zhang, Hongjun Zhang, Jinling Shi, Tianhe Xu, Keliang Li   +6 more
doaj   +1 more source

Telomeric double-strand DNA-binding proteins DTN-1 and DTN-2 ensure germline immortality in Caenorhabditis elegans

eLife, 2021
Telomeres are nucleoprotein complexes at the ends of chromosomes and are indispensable for the protection and lengthening of terminal DNA. Despite the evolutionarily conserved roles of telomeres, the telomeric double-strand DNA (dsDNA)-binding proteins ...
Io Yamamoto, Kexin Zhang, Jingjing Zhang, Egor Vorontsov, Hiroki Shibuya   +4 more
doaj   +1 more source