Results 1 to 10 of about 1,606,399 (268)

Reliable transfer of transcriptional gene regulatory networks between taxonomically related organisms

, 2009
Baumbach J, Rahmann S, Tauch A. Reliable transfer of transcriptional gene regulatory networks between taxonomically related organisms. BMC Systems Biology.
Sven Rahmann, Andreas Tauch, Tauch, Andreas, Baumbach, Jan, Jan Baumbach, Rahmann, Sven   +5 more
core   +1 more source

Nicotine as an odorant : a biochemical and electrophysiological study of receptors for nicotine in the olfactory epithelium of the rat [PDF]

The results suggest that nicotine vapour stimulates an in vitro olfactory preparation in three strains of rat and two strains of mouse, in a manner similar to known odorants.
Edwards, Damian Andrew
core  

Identification of High Affinity Fatty Acid Binding Sites on Human Serum Albumin by MM-PBSA Method [PDF]

Human serum albumin (HSA) has seven common fatty acid (FA) binding sites. In this study, we used the molecular mechanics Poisson-Boltzmann surface area method to identify high affinity FA binding sites on HSA in terms of binding free energy.
Fujiwara, Shin-ichi, 100000236, 4875, 00362880, 20231996, 96, Amisaki, Takashi, 100000075   +7 more
core  

CLIPS-1D: Analysis of multiple sequence alignments to deduce for residue-positions a role in catalysis, ligand-binding, or protein structure

, 2012
Background: One aim of the in silico characterization of proteins is to identify all residue-positions, which are crucial for function or structure. Several sequence-based algorithms exist, which predict functionally important sites.
Kück, Fabian, Rainer Merkl, Merkl, Rainer, Fabian Kück, Busch, Markus, Porfenenko, Mikhail, Mikhail Porfenenko, Merkl Rainer, Jan-Oliver Janda, Kück Fabian, Janda, Jan-Oliver, Porfenenko Mikhail, Janda Jan-Oliver, Busch Markus, Markus Busch   +14 more
core   +1 more source

Nucleosome-mediated cooperativity between transcription factors

, 2009
Cooperative binding of transcription factors (TFs) to cis-regulatory regions (CRRs) is essential for precision of gene expression in development and other processes.
Leonid A. Mirny, Mirny, Leonid A
core   +1 more source

Effector-Binding-Directed Dimerization and Dynamic Communication between Allosteric Sites of Ribonucleotide Reductase

, 2019
Proteins forming dimers or larger complexes can be strongly influenced by their effector-binding status. We investigated how the effector-binding event is coupled with interface formation via computer simulations, and we quantified the correlation of two
Tongye Shen (203925), Richard J. Lindsay (1649947), Bill Pham (6181139)   +2 more
core   +1 more source

Characterization of 2-[125I]iodomelatonin binding sites in the brain of a marsupial, Bennett's wallaby (Macropus rufogriseus rufogriseus)

, 1991
1. Specific high affinity binding of 2-[125I]iodomelatonin was detected in the brain of the pouch young of a marsupial, Bennett's wallaby. 2. Binding was rapid, stable, saturable and reversible. 3.
Paterson, A., Chong, Nelson W., Brinklow, B., Sugden, D., Loudon, A.L.   +4 more
core  

High-Mobility-Group protein I can modulate binding of transcription factors to the U5 region of the human immunodeficiency virus Type 1 proviral promoter

, 2000
HMG I/Y appears to be a multifunctional protein that relies on in its ability to interact with DNA in a structure-specific manner and with DNA, binding transcriptional activators via distinct protein-protein interaction surfaces.
Henderson, A., Tremethick, D.J., Siddon, N., Reeves, R., Bunce, M.   +4 more
core  

Two binding sites are better than one. [PDF]

Elife
Scott MK, Burke JE.
europepmc   +1 more source

Predicting unknown binding sites for transition-metal-based compounds in proteins. [PDF]

PLoS One
Levy A, Rothlisberger U.
europepmc   +1 more source