Results 1 to 10 of about 1,655,478 (266)
IGA MULTIPLE MYELOMA ASSESMENT WITH HEVYLITE ASSAY
Hematology, Transfusion and Cell Therapy, 2023 Introduction: A key element on Multiple Myeloma (MM) evaluation is the quantification of monoclonal proteins. Current techniques include Serum Protein Electrophoresis (SPE), Immunofixation (IFE) and Free Light Chain Assay (FLC, Freelite).
G Virginia +3 more
doaj +1 more source
Diagnostics, 2021 Despite tremendous progress being made in recent years, multiple myeloma (MM) remains a challenging disease. The laboratory plays a critical role in the overall management of patients.
Rafael Ríos-Tamayo +15 more
doaj +1 more source
Computing the protein binding sites [PDF]
BMC Bioinformatics, 2011 Identifying the location of binding sites on proteins is of fundamental importance for a wide range of applications including molecular docking, de novo drug design, structure identification and comparison of functional sites. Structural genomic projects are beginning to produce protein structures with unknown functions.
Fei Guo 0001, Lusheng Wang 0001
openaire +2 more sources
Elucidation of the binding mode of organic polysulfides on the human TRPA1 receptor
Frontiers in Physiology, 2023 Introduction: Previous studies have established that endogenous inorganic polysulfides have significant biological actions activating the Transient Receptor Potential Ankyrin 1 (TRPA1) receptor.
Balázs Nemes +10 more
doaj +1 more source
P53 Binding Sites in Transposons [PDF]
Frontiers in Genetics, 2012 Repeated regions of the genome harbor more functional information than commonly assumed. Two decades ago, a highly influential paper describing the consensus binding site for the key transcription factor p53 was published in Nature Genetics by el-Deiry et al. (1992). Recently, it has been observed that many p53 binding sites are species-specific (Jegga
Zemojtel, T., Vingron, M.
openaire +4 more sources
Сеченовский вестник, 2023 The development of neurodegenerative diseases is associated with proper neuronal circuit formation, axonal guidance. The DCC receptor (deleted in colorectal cancer / colorectal cancer suppressor) and SHH (sonic hedgehog protein) are among the key ...
D. D. Kotelnikov +3 more
doaj +1 more source
Galactoside-Binding Site in LacY [PDF]
Biochemistry, 2014 Although an X-ray crystal structure of lactose permease (LacY) has been presented with bound galactopyranoside, neither the sugar nor the residues ligating the sugar can be identified with precision at ~3.5 Å. Therefore, additional evidence is important for identifying side chains likely to be involved in binding.
Jiang, Xiaoxu +4 more
openaire +5 more sources
Micromachines, 2022 It is of great fundamental significance and practical application to understand the binding sites and dynamic process of the interaction between doxorubicin (DOX) and DNA molecules.
Ruihong Zhang +8 more
doaj +1 more source
Comprehensive Survey of Consensus Docking for High-Throughput Virtual Screening
Molecules, 2022 The rapid advances of 3D techniques for the structural determination of proteins and the development of numerous computational methods and strategies have led to identifying highly active compounds in computer drug design.
Clara Blanes-Mira +5 more
doaj +1 more source
Plants, 2021 Miltiradiene synthase (MS) genes, TwTPS27a and TwTPS27b, are the key diterpene synthase genes in the biosynthesis of triptolide, which is an important medicinally active diterpenoid in Tripterygium wilfordii.
Yanbo Huo +5 more
doaj +1 more source