Results 41 to 50 of about 2,894,166 (305)
Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids [PDF]
, 2016 Inward rectifier potassium (Kir) channel activity is controlled by plasma membrane lipids. Phosphatidylinositol-4,5-bisphosphate (PIP(2)) binding to a primary site is required for opening of classic inward rectifier Kir2.1 and Kir2.2 channels, but ...
Anna Stary-Weinzinger +55 more
core +2 more sources
Clinical Case Reports, 2018 Key Clinical Message Heavy/light chain (HLC) assay will enable us to evaluate the changes in the concentrations of iHLC and uHLC separately and to better identify whether the change observed is clonal or reactive.
Kazuyuki Shimizu +5 more
doaj +1 more source
Evaluation of a novel virtual screening strategy using receptor decoy binding sites [PDF]
, 2016 Virtual screening is used in biomedical research to predict the binding affinity of a large set of small organic molecules to protein receptor targets.
Kukol, A. +3 more
core +2 more sources
Promiscuity of the Euonymus Carbohydrate-Binding Domain
Biomolecules, 2012 Plants synthesize small amounts of carbohydrate-binding proteins on exposure to stress. For example, on exposure to drought, high salt, wounding and by treatment with some plant hormones or by pathogen attack. In contrast to the ‘classical’ plant lectins
Els J.M. Van Damme, Elke Fouquaert
doaj +1 more source
PocketGraph : graph representation of binding site volumes [PDF]
, 2009 The representation of small molecules as molecular graphs is a common technique in various fields of cheminformatics. This approach employs abstract descriptions of topology and properties for rapid analyses and comparison.
Kriegl, Jan M. +2 more
core +1 more source
Voronoi binding site models [PDF]
Journal of Computational Chemistry, 1987 AbstractA frequently occurring problem in drug design and enzymology is that the binding constants for several compounds to the same site are known, but the geometry and energetic interactions of the site are not. This paper presents in detail a novel approach to the problem which accurately but compactly represents the allowed conformation space of ...
openaire +3 more sources
Structure and Metal Binding Properties of ZnuA, a Periplasmic Zinc Transporter from \u3cem\u3eEscherichia coli\u3c/em\u3e [PDF]
, 2008 ZnuA is the periplasmic Zn2+-binding protein associated with the high-affinity ATP-binding cassette ZnuABC transporter from Escherichia coli. Although several structures of ZnuA and its homologs have been determined, details regarding metal ion ...
Bennett, Brian +9 more
core +2 more sources
Spatial Layouts of Low‐Entropy Hydration Shells Guide Protein Binding
Global Challenges, 2023 Protein–protein binding enables orderly biological self‐organization and is therefore considered a miracle of nature. Protein‒protein binding is driven by electrostatic forces, hydrogen bonding, van der Waals force, and hydrophobic interactions.
Lin Yang +9 more
doaj +1 more source
Functional microRNA binding site variants
Molecular Oncology, 2019 Germline single nucleotide polymorphisms are one of the most common genetic variations. Polymorphisms that cause nonsynonymous mutations in gene coding regions are known to cause serious deleterious downstream effects.
Ye Yuan, Joanne B. Weidhaas
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Molecular Plant-Microbe Interactions, 2021 Identification of transcription factor binding sites is one of the most important steps in understanding the function of transcription factors and regulatory networks in organisms. The assay for transposase accessible chromatin sequencing (ATAC-seq) is a
Xiaoyang Chen +5 more
doaj +1 more source