Results 61 to 70 of about 2,894,166 (305)

Trichinella spiralis Calreticulin S-Domain Binds to Human Complement C1q to Interfere With C1q-Mediated Immune Functions

Frontiers in Immunology, 2020
Helminths develop strategies to escape host immune responses that facilitate their survival in the hostile host immune environment. Trichinella spiralis, a tissue-dwelling nematode, has developed a sophisticated strategy to escape complement attack.
Shuai Shao, Chunyue Hao, Bin Zhan, Qinghui Zhuang, Limei Zhao, Yi Chen, Jingjing Huang, Xinping Zhu   +7 more
doaj   +1 more source

Rubredoxin Variant Folds without Iron [PDF]

, 1999
Pyroccocus furiosus rubredoxin (PFRD), like most studied hyperthermophilic proteins, does not undergo reversible folding. The irreversibility of folding is thought to involve PFRD’s iron-binding site.
Mayo, Stephen L., Strop, Pavel
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Characterization of α-actin isoforms in white and red skeletal muscle types of Leporinus macrocephalus (Characiformes, Anostomidae)

Anais da Academia Brasileira de Ciências, 2015
RESUMO Dois genes de α-actina do peixe Leporinus macrocephalus, referindo-se aos tecidos musculares branco e vermelho, foram isolados. Isoformas de actinas, que principalmente diferiram por uma substituição Ser/Ala155, podem ter uma significância ...
FERNANDA A. ALVES-COSTA, MAELI D.P. SILVA, ADRIANE P. WASKO   +2 more
doaj   +1 more source

Accurate Sequence-Based Prediction of Deleterious nsSNPs with Multiple Sequence Profiles and Putative Binding Residues

Biomolecules, 2021
Non-synonymous single nucleotide polymorphisms (nsSNPs) may result in pathogenic changes that are associated with human diseases. Accurate prediction of these deleterious nsSNPs is in high demand.
Ruiyang Song, Baixin Cao, Zhenling Peng, Christopher J. Oldfield, Lukasz Kurgan, Ka-Chun Wong, Jianyi Yang   +6 more
doaj   +1 more source

Structural fingerprints of transcription factor binding site regions [PDF]

, 2009
Fourier transforms are a powerful tool in the prediction of DNA sequence properties, such as the presence/absence of codons. We have previously compiled a database of the structural properties of all 32,896 unique DNA octamers.
Christopher Hunter, Collins, Eleanor J. Gardiner, Fickett, Kampa, Packer, Peter Willett, Tiwari, Waterston   +8 more
core   +2 more sources

Inferring Binding Energies from Selected Binding Sites

PLoS Computational Biology, 2009
We employ a biophysical model that accounts for the non-linear relationship between binding energy and the statistics of selected binding sites. The model includes the chemical potential of the transcription factor, non-specific binding affinity of the protein for DNA, as well as sequence-specific parameters that may include non-independent ...
Zhao, Yue, Granas, David, Stormo, Gary D
openaire   +5 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Inhibition of Neisseria gonorrhoeae complement-mediated killing during acute gonorrhea is dependent upon the IgG2:IgG3 antibody ratio

mBio
Excessive binding of antibodies to the bacterial cell surface can paradoxically increase resistance of some Gram-negative pathogens to complement-mediated killing (CMK).
Samantha A. McKeand, Sian E. Faustini, Alex Cook, Nikki Kennett, Mark T. Drayson, Adam F. Cunningham, Ian R. Henderson, Christoph M. Tang, Jonathan D. C. Ross, Jeffrey A. Cole, Amanda E. Rossiter-Pearson   +10 more
doaj   +1 more source

TFEBexplorer: An integrated tool to study genes regulated by the stress-responsive Transcription Factor EB

Autophagy Reports, 2022
TFEBexplorer is a comprehensive web-tool to study genes modulated by the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, that integrates multiple datasets following genetic perturbation of TFEB with ...
Rossella De Cegli, Diego Carrella, Diletta Siciliano, Gennaro Gambardella, Gennaro Napolitano, Chiara Di Malta, Andrea Ballabio, Diego di Bernardo   +7 more
doaj   +1 more source