Results 11 to 20 of about 1,655,478 (266)
Frontiers in Bioengineering and Biotechnology, 2022 Identification of protein–ligand binding sites plays a critical role in drug discovery. However, there is still a lack of targeted drug prediction for DNA-binding proteins. This study aims at the binding sites of DNA-binding proteins and drugs, by mining
Wei Wang +7 more
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Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations
BMC Immunology, 2019 Background We sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or IgG1 + IgG3 before and after ...
Antony R. Parker +5 more
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Influence of N–1 substituent properties on binding affinities of arylpiperazines to the binding site of 5-HT1A receptor [PDF]
Journal of the Serbian Chemical Society, 2006 Serotonin receptors (5-HTRs), especially the 5-HT1A subtype, have been the subject of intensive research for the past decade, due to their function in human physiology.
MARIO V. ZLATOVIC +4 more
doaj +3 more sources
Practical Laboratory Medicine, 2016 Objectives: Anti-pneumococcal capsular polysaccharide (PCP) IgM, IgG and IgA ELISAs have been developed to aid assessment of the adaptive immune system. The relationship between the concentrations of PCP IgM, IgG, and IgA was investigated.
Antony R. Parker +2 more
doaj +1 more source
Frontiers in Immunology, 2019 Salvage of endogenous immunoglobulin G (IgG) by the neonatal Fc receptor (FcRn) is implicated in many clinical areas, including therapeutic monoclonal antibody kinetics, patient monitoring in IgG multiple myeloma, and antibody-mediated transplant ...
Felicity Kendrick +4 more
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Being a binding site: Characterizing residue composition of binding sites on proteins [PDF]
Bioinformation, 2007 The Protein Data Bank contains the description of more than 45,000 three-dimensional protein and nucleic-acid structures today. Started to exist as the computer-readable depository of crystallographic data complementing printed articles, the proper interpretation of the content of the individual files in the PDB still frequently needs the detailed ...
Ivan, G, Szabadka, Z, Grolmusz, V
openaire +3 more sources
Mild Hypogammaglobulinemia Can Be a Serious Condition
Frontiers in Immunology, 2018 Background: Most patients with primary antibody deficiency (PAD) suffer from less well-described and understood forms of hypogammaglobulinemia (unclassified primary antibody deficiency, unPAD).
Lisanne M. A. Janssen +10 more
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Molecular docking study of ethyl acetate fraction of Selaginella doederleinii Hieron extract as anti-Warburg effect in breast cancer [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2023 Context: Aerobic glycolysis is a breast cancer hallmark that has become a novel target for anticancer therapy. GLUT1, HK2, PKM2, and LDHA are oncogenic proteins in the pathway.
Honesty N. Pinanti +4 more
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The response to Typhi Vi vaccination is compromised in individuals with primary immunodeficiency
Heliyon, 2017 Measurement of an individuals ability to respond to polysaccharide antigens is a crucial test to determine adaptive immunity. Currently the response to Pneumovax® is utilized but with the success of Prevnar®, measurement of the response to Pneumovax may ...
Jeevani Kumarage +10 more
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miR-496 inhibits proliferation via LYN and AKT pathway in gastric cancer
Open Medicine, 2021 MicroRNAs (miRNAs) operate as tumor suppressor or carcinogen to regulate cell proliferation, metastasis, invasion, differentiation, apoptosis, and metabolic process.
Su Rui, Zhao Enhong, Zhang Jun
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