The Chromosomal High-Affinity Binding Sites for the Drosophila Dosage Compensation Complex [PDF]
, 2008 Dosage compensation in male Drosophila relies on the X chromosome-specific recruitment of a chromatin-modifying machinery, the dosage compensation complex (DCC). The principles that assure selective targeting of the DCC are unknown.
Grimaud, Charlotte +16 more
core +1 more source
Turnover and function of DNA methylation at transcription factor binding sites [PDF]
, 2014 Cell type identity is largely determined by regulatory networks consistent of various transcription factors. Transcription factor activity requires interaction with DNA and thus critically depends on the accessibility of binding motifs.
Feldmann, Angelika
core +1 more source
Nucleotide-Binding Sites of the Heterodimeric LmrCD ABC-Multidrug Transporter of Lactococcus lactis Are Asymmetric [PDF]
, 2006 LmrCD is a lactococcal, heterodimeric multidrug transporter, which belongs to the ABC superfamily. It consists of two half-transporters, LmrC and LmrD, that are necessary and sufficient for drug extrusion and ATP hydrolysis.
Konings, Wil N. +7 more
core +1 more source
Binding Sites of Bicarbonate in PEP Carboxylase
, 2023 PhosphoEnolPyruvate Carboxylase is used in plant metabolism for fruit maturation or seed development, as well as in the C4 and CAM mechanisms in photosynthesis where it is used for the capture of hydrated CO2 (bicarbonate).
Nicolas, Chéron
core +1 more source
Models incorporating chromatin modification data identify functionally important p53 binding sites
, 2013 Genome-wide prediction of transcription factor binding sites is notoriously difficult. We have developed and applied a logistic regression approach for prediction of binding sites for the p53 transcription factor that incorporates sequence information ...
Barker, Daniel +2 more
core +1 more source
A client‐binding site of Cdc37 [PDF]
The FEBS Journal, 2005 The molecular chaperone Hsp90 is distinct from Hsp70 and chaperonin in that client proteins are apparently restricted to a subset of proteins categorized as cellular signaling molecules. Among these, many specific protein kinases require the assistance of Hsp90 and its co‐chaperone Cdc37/p50 for their biogenesis.
Kazuya, Terasawa, Yasufumi, Minami
openaire +2 more sources
Use of top-down and bottom-up fourier transform ion cyclotron resonance mass spectrometry for mapping calmodulin sites modified by platinum anticancer drugs [PDF]
, 2011 Calmodulin (CaM) is a highly conserved, ubiquitous, calcium-binding protein; it binds to and regulates many different protein targets, thereby functioning as a calcium sensor and signal transducer.
Lin, Tzu-Yung +17 more
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Functional domains of the influenza A virus PB2 protein:identification of NP- and PB1-binding sites
, 2004 Influenza virus genomic RNA segments are packaged into ribonucleoprotein (RNP) structures by the PB1, PB2, and PA subunits of an RNA polymerase and a single-strand RNA-binding nucleoprotein (NP).
Poole, Emma +4 more
core +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source