Results 41 to 50 of about 1,682,340 (366)

Discovery of Cisplatin Binding to Thymine and Cytosine on a Single-Stranded Oligodeoxynucleotide by High Resolution FT-ICR Mass Spectrometry

Molecules, 2019
The clinically widely-used anticancer drug, cisplatin, binds strongly to DNA as a DNA-damaging agent. Herein, we investigated the interaction of cisplatin with a 15-mer single-stranded C,T-rich oligodeoxynucleotide, 5′-CCTT4CTT7G8C9T10TCTCC-3′
Wenjuan Zeng, Yanyan Zhang, Wei Zheng, Qun Luo, Juanjuan Han, Jian’an Liu, Yao Zhao, Feifei Jia, Kui Wu, Fuyi Wang   +9 more
doaj   +1 more source

Structural Dynamics of DPP-4 and Its Influence on the Projection of Bioactive Ligands

Molecules, 2018
Dipeptidyl peptidase-4 (DPP-4) is a target to treat type II diabetes mellitus. Therefore, it is important to understand the structural aspects of this enzyme and its interaction with drug candidates.
Simone Queiroz Pantaleão, Eric Allison Philot, Pedro Túlio de Resende-Lara, Angélica Nakagawa Lima, David Perahia, Maria Atanassova Miteva, Ana Ligia Scott, Kathia Maria Honorio   +7 more
doaj   +1 more source

Comprehensive Analysis of Breast Cancer Cell Lines: Genome-wide Insights from ChIP-seq Analysis

Biomedical and Biotechnology Research Journal
Context: Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is the central system in epigenomic exploration. Chromatin immunoprecipitation coupled with sequencing (ChIP-seq) is an important technology to identify the genome-wide location of ...
Tanishq Sahu, Ruchi Yadav
doaj   +1 more source

The ontogeny of 2-[125I]iodomelatonin binding sites in chicken brain [PDF]

, 1992
The characteristics of the binding sites for 2-[125I]iodomelatoion in were studied in chicken brain membranes during development. Specific binding, defined using cold melatonin (1 μM), was detected as early as 8-day-old embryos.
Chong, Nelson W., Sugden, D.
core   +1 more source

BTFBS: Binding Prediction of Bacterial Transcription Factors and Binding Sites Based on Deep Learning

Mathematics
The binding of transcription factors (TFs) to TF binding sites plays a vital role in the process of regulating gene expression and evolution. With the development of machine learning and deep learning, some successes have been achieved in predicting ...
Bingbing Jin, Song Liang, Xiaoqian Liu, Rui Zhang, Yun Zhu, Yuanyuan Chen, Guangjin Liu, Tao Yang   +7 more
doaj   +1 more source

A client‐binding site of Cdc37 [PDF]

The FEBS Journal, 2005
The molecular chaperone Hsp90 is distinct from Hsp70 and chaperonin in that client proteins are apparently restricted to a subset of proteins categorized as cellular signaling molecules. Among these, many specific protein kinases require the assistance of Hsp90 and its co‐chaperone Cdc37/p50 for their biogenesis.
Kazuya, Terasawa, Yasufumi, Minami
openaire   +2 more sources

Use of top-down and bottom-up fourier transform ion cyclotron resonance mass spectrometry for mapping calmodulin sites modified by platinum anticancer drugs [PDF]

, 2011
Calmodulin (CaM) is a highly conserved, ubiquitous, calcium-binding protein; it binds to and regulates many different protein targets, thereby functioning as a calcium sensor and signal transducer.
Lin, Tzu-Yung, Sadler, P. J., Steve L. Van Orden, Yulin Qi, Qi, Yulin, Yao Zhao, Peter B. O’Connor, Peter J. Sadler, Pizarro, Ana M., Ana M. Pizarro, Barrow, Mark P., O’Connor, Peter B., Huilin Li, Tzu-Yung Lin, Van Orden, Steve L., Zhao, Yao, (Researcher in chemistry), Mark P. Barrow, Li, Huilin   +17 more
core   +1 more source

Measurable Residual Disease Monitoring During Treatment for Pediatric Acute Myeloid Leukemia in First Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survival after relapse in pediatric acute myeloid leukemia (AML) remains poor, highlighting the critical importance of identifying prognostic factors to guide optimal relapse management. Methods We investigated the prognostic impact of multiparameter flow cytometry (MFC) measurable residual disease (MRD) in 188 patients with first ...
Camilla Poulsen, Kristian Juul Sandahl, Lene Karlsson, Jonas Abrahamsson, Nira Arad‐Cohen, Daniel Cheuk, Barbara De Moerloose, Linda Fogelstrand, Jose Maria Fernandez Navarro, Bianca F. Goemans, Kirsi Jahnukainen, Gertjan Kaspers, Zhanna Kovalova, Monica Cheng Munthe‐Kaas, Ulrika Norén‐Nyström, Josefine Palle, Ramune Pasauliene, Cornelis Jan Pronk, Kadri Saks, Anne Tierens, Henrik Hasle, Kristian Løvvik Juul‐Dam   +21 more
wiley   +1 more source

Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates [PDF]

, 2012
This work was supported by the UK Medical Research Council via a Developmental Pathway Funding Scheme award and a Research Councils UK fellowship in marine biology.14-3-3 proteins regulate cellular responses to stimuli by docking onto pairs of ...
Toth, Rachel, Tinti, Michele, Johnson, Catherine, Ferrier, David Ellard Keith, MacKintosh, Carol, Ferrier, David E. K., MacKintosh, Carol; id_orcid   +6 more
core   +1 more source

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source