Results 41 to 50 of about 4,911,121 (311)

Comprehensive Analysis of Breast Cancer Cell Lines: Genome-wide Insights from ChIP-seq Analysis

Biomedical and Biotechnology Research Journal
Context: Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is the central system in epigenomic exploration. Chromatin immunoprecipitation coupled with sequencing (ChIP-seq) is an important technology to identify the genome-wide location of ...
Tanishq Sahu, Ruchi Yadav
doaj   +1 more source

BTFBS: Binding Prediction of Bacterial Transcription Factors and Binding Sites Based on Deep Learning

Mathematics
The binding of transcription factors (TFs) to TF binding sites plays a vital role in the process of regulating gene expression and evolution. With the development of machine learning and deep learning, some successes have been achieved in predicting ...
Bingbing Jin, Song Liang, Xiaoqian Liu, Rui Zhang, Yun Zhu, Yuanyuan Chen, Guangjin Liu, Tao Yang   +7 more
doaj   +1 more source

Prediction of Functional Sites in SCOP Domains using Dynamics Perturbation Analysis [PDF]

, 2008
Dynamics perturbation analysis (DPA) finds regions in a protein structure where proteins are "ticklish", i.e., where interactions cause a large change in protein dynamics.
Michael E. Wall, Dengming Ming, Judith D. Cohn   +2 more
core   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates [PDF]

, 2012
This work was supported by the UK Medical Research Council via a Developmental Pathway Funding Scheme award and a Research Councils UK fellowship in marine biology.14-3-3 proteins regulate cellular responses to stimuli by docking onto pairs of ...
Toth, Rachel, Tinti, Michele, Johnson, Catherine, Ferrier, David Ellard Keith, MacKintosh, Carol, Ferrier, David E. K., MacKintosh, Carol; id_orcid   +6 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Analysis of Structures of SARS-CoV-2 Papain-like Protease Bound with Ligands Unveils Structural Features for Inhibiting the Enzyme

Molecules
The COVID-19 pandemic, driven by the novel coronavirus SARS-CoV-2, has drastically reshaped global health and socioeconomic landscapes. The papain-like protease (PLpro) plays a critical role in viral polyprotein cleavage and immune evasion, making it a ...
Ann Varghese, Jie Liu, Bailang Liu, Wenjing Guo, Fan Dong, Tucker A. Patterson, Huixiao Hong   +6 more
doaj   +1 more source

The role of miRNA genes participating in VHL-HIF1α in clear cell renal cell carcinoma

Вестник урологии, 2019
Introduction. Much attention in ccRCC development is paid to VHL-HIF1α pathway genes. Numerous genes involved in the pathogenesis of ccRCC are targets for miRNA.
V. N. Pavlov, I. R. Gilyazova, A. A. Izmailov, E. A. Klimentova, I. R. Sultanov, M. A. Bermishev, Z. R. Akhmadeev, A. Kh. Nurgalieva, G. V. Ishbulatova, E. K. Khusnutdinova   +9 more
doaj   +1 more source

Cis-regulatory elements in conserved non-coding sequences of nuclear receptor genes indicate for crosstalk between endocrine systems

Open Medicine, 2021
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene expression when bound to specific DNA sequences. Crosstalk between steroid NR systems has been studied for understanding the development of hormone-driven cancers but ...
Cruz Maria Araceli Diaz, Lund Dan, Szekeres Ferenc, Karlsson Sandra, Faresjö Maria, Larsson Dennis   +5 more
doaj   +1 more source

The Na+ Binding Site of Thrombin [PDF]

Journal of Biological Chemistry, 1995
Thrombin is an allosteric serine protease existing in two forms, slow and fast, targeted toward anticoagulant and procoagulant activities. The slow --> fast transition is induced by Na+ binding to a site contained within a cylindrical cavity formed by three antiparallel beta-strands of the B-chain (Met180-Tyr184a, Lys224-Tyr228, and Val213-Gly219 ...
E, Di Cera, E R, Guinto, A, Vindigni, Q D, Dang, Y M, Ayala, M, Wuyi, A, Tulinsky   +6 more
openaire   +2 more sources