Results 51 to 60 of about 5,097,951 (211)
Charge environments around phosphorylation sites in proteins [PDF]
, 2008 Background: Phosphorylation is a central feature in many biological processes. Structural analyses have identified the importance of charge-charge interactions, for example mediating phosphorylation-driven allosteric change and protein binding to ...
Kitchen, James +6 more
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Comprehensive Analysis of Breast Cancer Cell Lines: Genome-wide Insights from ChIP-seq Analysis
Biomedical and Biotechnology Research JournalContext: Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is the central system in epigenomic exploration. Chromatin immunoprecipitation coupled with sequencing (ChIP-seq) is an important technology to identify the genome-wide location of ...
Tanishq Sahu, Ruchi Yadav
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MathematicsThe binding of transcription factors (TFs) to TF binding sites plays a vital role in the process of regulating gene expression and evolution. With the development of machine learning and deep learning, some successes have been achieved in predicting ...
Bingbing Jin +7 more
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Data of protein-RNA binding sites
Data in Brief, 2017 Despite the increasing number of protein-RNA complexes in structure databases, few data resources have been made available which can be readily used in developing or testing a method for predicting either protein-binding sites in RNA sequences or RNA ...
Wook Lee +3 more
doaj +1 more source
Open Medicine, 2021 Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene expression when bound to specific DNA sequences. Crosstalk between steroid NR systems has been studied for understanding the development of hormone-driven cancers but ...
Cruz Maria Araceli Diaz +5 more
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The role of miRNA genes participating in VHL-HIF1α in clear cell renal cell carcinoma
Вестник урологии, 2019 Introduction. Much attention in ccRCC development is paid to VHL-HIF1α pathway genes. Numerous genes involved in the pathogenesis of ccRCC are targets for miRNA.
V. N. Pavlov +9 more
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BioMetAll: Identifying Metal-Binding Sites in Proteins from Backbone Preorganization [PDF]
, 2020 With a large amount of research dedicated to decoding how metallic species bind to protein, in silico methods are interesting allies for experimental procedures.
Giuseppe, Sciortino +5 more
core +2 more sources
A method for rapidly screening functionality of actin mutants and tagged actins [PDF]
Biological Procedures Online, 2004 Recombinant production and biochemical analysis of actin mutants has been hampered by the fact that actin has an absolute requirement for the eukaryotic chaperone CCT to reach its native state.
Rommelaere Heidi +4 more
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The Na+ Binding Site of Thrombin [PDF]
Journal of Biological Chemistry, 1995 Thrombin is an allosteric serine protease existing in two forms, slow and fast, targeted toward anticoagulant and procoagulant activities. The slow --> fast transition is induced by Na+ binding to a site contained within a cylindrical cavity formed by three antiparallel beta-strands of the B-chain (Met180-Tyr184a, Lys224-Tyr228, and Val213-Gly219 ...
E, Di Cera +6 more
openaire +2 more sources
Fundamentally different strategies for transcriptional regulation are revealed by analysis of binding motifs [PDF]
, 2008 To regulate a particular gene, a transcription factor (TF) needs to bind a specific genome location. How is this genome address specified amid the presence of ~10^6^-10^9^ decoy sites? Our analysis of 319 known TF binding motifs clearly demonstrates that
Zeba Wunderlich, Leonid Mirny
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