Results 51 to 60 of about 1,682,340 (366)

Pharmacological identity of 2-[125I]iodomelatonin binding sites in chicken brain and sheep pars tuberalis [PDF]

, 1991
2-[125I]Iodomelatonin was used to compare the binding and pharmacological characteristics of the melatonin receptor sites found in chicken brain and sheep pars tuberalis.
Chong, Nelson W., Sugden, D.
core   +1 more source

Analysis of Structures of SARS-CoV-2 Papain-like Protease Bound with Ligands Unveils Structural Features for Inhibiting the Enzyme

Molecules
The COVID-19 pandemic, driven by the novel coronavirus SARS-CoV-2, has drastically reshaped global health and socioeconomic landscapes. The papain-like protease (PLpro) plays a critical role in viral polyprotein cleavage and immune evasion, making it a ...
Ann Varghese, Jie Liu, Bailang Liu, Wenjing Guo, Fan Dong, Tucker A. Patterson, Huixiao Hong   +6 more
doaj   +1 more source

The role of miRNA genes participating in VHL-HIF1α in clear cell renal cell carcinoma

Вестник урологии, 2019
Introduction. Much attention in ccRCC development is paid to VHL-HIF1α pathway genes. Numerous genes involved in the pathogenesis of ccRCC are targets for miRNA.
V. N. Pavlov, I. R. Gilyazova, A. A. Izmailov, E. A. Klimentova, I. R. Sultanov, M. A. Bermishev, Z. R. Akhmadeev, A. Kh. Nurgalieva, G. V. Ishbulatova, E. K. Khusnutdinova   +9 more
doaj   +1 more source

Cis-regulatory elements in conserved non-coding sequences of nuclear receptor genes indicate for crosstalk between endocrine systems

Open Medicine, 2021
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene expression when bound to specific DNA sequences. Crosstalk between steroid NR systems has been studied for understanding the development of hormone-driven cancers but ...
Cruz Maria Araceli Diaz, Lund Dan, Szekeres Ferenc, Karlsson Sandra, Faresjö Maria, Larsson Dennis   +5 more
doaj   +1 more source

Animal‐Assisted Activities With Therapy Dogs in Pediatric Oncology: A Multicenter Survey of the Current Status, Implementation, and Challenges in Germany, Austria, and Switzerland

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Animal‐assisted activities (AAAs) with therapy dogs have shown positive effects on patient well‐being and quality of life in various areas of medicine, including pediatric oncology. However, research on this topic is limited. The aim of this study is to present the current status of AAA in pediatric oncology in Germany, Austria, and
Jan‐Marius Wedig, Birgit Burkhardt, Christof M. Kramm, Kira Ostermann, Sarah C. Goretzki, Uta Dirksen, Nico Kurpiers, Michael M. Schündeln   +7 more
wiley   +1 more source

Analysis of shape, properties and "druggability" of protein binding pockets [PDF]

, 2009
Kenntnisse über die dreidimensionale Struktur therapeutisch relevanter Zielproteine bieten wertvolle Informationen für den rationalen Wirkstoffentwurf.
Weisel, Martin
core  

Characterizations of a Food Decapeptide Chelating with Zn(II)

eFood, 2020
Walnut proteins and peptides have been reported to have great zinc-carrying activity. In this study, the decapeptide EPNGLLLPQY (WP-10) derived from walnut protein has been prepared to figure out zinc binding mechanisms and structure–activity ...
Weiwei Fan, Zhenyu Wang, Zhishen Mu, Ming Du, Lianzhou Jiang, Hesham R. EI-Seedi, Cong Wang   +6 more
doaj   +1 more source

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Fundamentally different strategies for transcriptional regulation are revealed by analysis of binding motifs [PDF]

, 2008
To regulate a particular gene, a transcription factor (TF) needs to bind a specific genome location. How is this genome address specified amid the presence of ~10^6^-10^9^ decoy sites? Our analysis of 319 known TF binding motifs clearly demonstrates that
Zeba Wunderlich, Leonid Mirny
core   +1 more source

Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA

Cell Reports, 2017
Jasmonates (JAs) are essential plant hormones that play important roles in the regulation of plant growth and the response to environmental stress. In the JA signaling pathway, the core transcription factors are a class of basic helix-loop-helix (bHLH ...
Teng-fei Lian, Yong-ping Xu, Lan-fen Li, Xiao-Dong Su   +3 more
doaj   +1 more source