Results 71 to 80 of about 5,097,951 (211)
A new histochemical method using human placenta alkaline phosphatase for demonstrating concanavalin A binding sites on cell surfaces [PDF]
, 1975 Human placenta alkaline phosphatase (HP-ALP), a glycoprotein, was stained histochemically for the purpose of examining the concanavalin A (Con A) binding sites on the cell surface. HP-ALP was bound to the cell surface by Con A.
Oda, Takuzo +2 more
core +1 more source
Number of matched binding sites.
, 2021 Number of matched binding sites.
Xingjie Pan (1702678) +1 more
core +1 more source
Tuning genetic clocks employing DNA binding sites. [PDF]
PLoS ONE, 2012 Periodic oscillations play a key role in cell physiology from the cell cycle to circadian clocks. The interplay of positive and negative feedback loops among genes and proteins is ubiquitous in these networks.
Shridhar Jayanthi, Domitilla Del Vecchio
doaj +1 more source
, 1991 2-[125I]Iodomelatonin was used to compare the binding and pharmacological characteristics of the melatonin receptor sites found in chicken brain and sheep pars tuberalis.
Chong, Nelson W., Sugden, D.
core +1 more source
Turnover and function of DNA methylation at transcription factor binding sites [PDF]
, 2014 Cell type identity is largely determined by regulatory networks consistent of various transcription factors. Transcription factor activity requires interaction with DNA and thus critically depends on the accessibility of binding motifs.
Feldmann, Angelika
core +1 more source
The metal binding site of zoocin A [PDF]
JBIC Journal of Biological Inorganic Chemistry, 2008 Direct metal analysis of the bacteriolytic exoenzyme zoocin A failed to unequivocally identify a putative metal cofactor; hence, indirect experiments utilizing NMR were undertaken to settle this question. Cd(2+) as a surrogate metal ion was reconstituted into EDTA-treated, metal-free recombinant zoocin, and (113)Cd-NMR was employed to explore binding ...
Yinghua, Chen +3 more
openaire +2 more sources
CLIPS-1D: Analysis of multiple sequence alignments to deduce for residue-positions a role in catalysis, ligand-binding, or protein structure [PDF]
, 2012 Background: One aim of the in silico characterization of proteins is to identify all residue-positions, which are crucial for function or structure. Several sequence-based algorithms exist, which predict functionally important sites.
Kück, Fabian +14 more
core +1 more source
A phenotypic drug discovery approach by latent interaction in deep learning
Royal Society Open ScienceContemporary drug discovery paradigms rely heavily on binding assays about the bio-physicochemical processes. However, this dominant approach suffers from overlooked higher-order interactions arising from the intricacies of molecular mechanisms, such as ...
Tat Wai Billy Yu
doaj +1 more source
Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2 [PDF]
, 2015 Ets-2, like its closely related homologue Ets-1, is a member of the Ets family of DNA binding transcription factors. Both proteins are subject to multiple levels of regulation of their DNA binding and transactivation properties.
Gileadi, Opher +3 more
core +1 more source
eLife, 2019 P2X3 receptor channels expressed in sensory neurons are activated by extracellular ATP and serve important roles in nociception and sensory hypersensitization, making them attractive therapeutic targets.
Mufeng Li +7 more
doaj +1 more source