Results 91 to 100 of about 1,682,340 (366)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Interaction of fatty acids and phospholipids with multiple binding sites on the potassium channel KcsA [PDF]

, 2011
The majority of lipids that interact with a transmembrane protein act as a solvent for the protein, forming a shell around it; these lipids are called annular or boundary lipids.
Bolivar Gonzalez, Juan
core  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

PocketGraph : graph representation of binding site volumes [PDF]

, 2009
The representation of small molecules as molecular graphs is a common technique in various fields of cheminformatics. This approach employs abstract descriptions of topology and properties for rapid analyses and comparison.
Weisel, Martin, G Schneider, Kriegl, Jan M., M Weisel, Schneider, Gisbert (Prof. Dr.), J Kriegl   +5 more
core   +1 more source

Predicting the biological activity of selected phytochemicals in Alsophila spinulosa leaves against 4-aminobutyrate-aminotransferase: A potential antiepilepsy agents

Eclética Química
The use of medicinal plants as an alternative mean of treating various diseases has drawn the attention of several researchers. The desire to find lasting solutions to epilepsy among humans increases every day.
Oyebamiji Abel Kolawole, Olujinmi Faith Eniola, Akintelu Sunday Adewale, Adetuyi Babatunde, Ogunlana Olubanke, Semire Banjo, Akintayo Emmanuel Temitope, Akintayo Cecilia Olufunke, Babalola Jonathan Oyebamiji, Olawoye Bolanle Mary, Aworinde Juliana Oluwasayo   +10 more
doaj   +1 more source

Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP

eLife, 2019
P2X3 receptor channels expressed in sensory neurons are activated by extracellular ATP and serve important roles in nociception and sensory hypersensitization, making them attractive therapeutic targets.
Mufeng Li, Yao Wang, Rahul Banerjee, Fabrizio Marinelli, Shai Silberberg, José D Faraldo-Gómez, Motoyuki Hattori, Kenton Jon Swartz   +7 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Discrimination between RNA binding sites and DNA binding sites. [PDF]

, 2015
For DNA binding site prediction programs, DNA binding sites (3.5Å as distance cutoff) from a data set are taken as positive while RNA binding sites from another data set are taken as negative, the AUC values of these discriminations are plotted with ...
Eric Westhof (11340), Zhichao Miao (838497)   +1 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Genome-scale annotation of protein binding sites via language model and geometric deep learning [PDF]

Revealing protein binding sites with other molecules, such as nucleic acids, peptides, or small ligands, sheds light on disease mechanism elucidation and novel drug design.
Yuan, Qianmu, Tian, Chong, Yang, Yuedong
core   +1 more source