On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine [PDF]
, 2009 Protein kinases are important regulatory enzymes in signal transduction and in cell regulation. Understanding inhibition mechanisms of kinases is important for the further development of new therapies for cancer and inflammatory diseases.
William R. Pitt +3 more
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Identification of a protein S–binding site in the C2 domain of factor VIII light chain
Research and Practice in Thrombosis and HaemostasisBackground: We demonstrated that protein S (PS) directly impairs the intrinsic tenase complex, independent of activated protein C (APC), by competitively inhibiting the binding of factor (F)IXa to the A2 domain (residues 488-490) and light chain (LCh) of
Shoko Furukawa +2 more
doaj +1 more source
Detection of inflammation- and neoplasia-associated alterations in human large intestine using plant/invertebrate lectins, galectin-1 and neoglycoproteins [PDF]
, 1998 Commonly, plant and invertebrate lectins are accepted glycohistochemical tools for the analysis of normal and altered structures of glycans in histology and pathology.
Korabiowska, M. +3 more
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Measuring similarities between transcription factor binding sites
BMC Bioinformatics, 2005 Background Collections of transcription factor binding profiles (Transfac, Jaspar) are essential to identify regulatory elements in DNA sequences. Subsets of highly similar profiles complicate large scale analysis of transcription factor binding sites ...
Gonze Didier +2 more
doaj +1 more source
, 2011 The majority of lipids that interact with a transmembrane protein act as a solvent for the protein, forming a shell around it; these lipids are called annular or boundary lipids.
Bolivar Gonzalez, Juan
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Dissection and prediction of RNA-binding sites on proteins
, 2010 RNA-binding proteins are involved in many important regulatory processes in cells and their study is essential for a complete understanding of living organisms. They show a large variability from both structural and functional points of view.
Laura Pérez-Cano +5 more
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Structure-Based Prediction of Transcription Factor Binding Sites
Tsinghua Science and Technology, 2014 Transcription Factors (TFs) are a very diverse family of DNA-binding proteins that play essential roles in the regulation of gene expression through binding to specific DNA sequences.
Jun-tao Guo, Shane Lofgren, Alvin Farrel
doaj +1 more source
Calcium binding activity of the epidermal growth factor-like domains of the apicomplexan microneme protein EtMIC4 [PDF]
, 2005 Microneme proteins are secreted from apicomplexan parasites during invasion of host cells and they play crucial roles in parasite-host cell adhesion.
Gill, A C +4 more
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Adaptive evolution of transcription factor binding sites
BMC Evolutionary Biology, 2004 Background The regulation of a gene depends on the binding of transcription factors to specific sites located in the regulatory region of the gene. The generation of these binding sites and of cooperativity between them are essential building blocks in ...
Berg Johannes +2 more
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Identification of High Affinity Fatty Acid Binding Sites on Human Serum Albumin by MM-PBSA Method [PDF]
Human serum albumin (HSA) has seven common fatty acid (FA) binding sites. In this study, we used the molecular mechanics Poisson-Boltzmann surface area method to identify high affinity FA binding sites on HSA in terms of binding free energy.
Fujiwara, Shin-ichi +7 more
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