Results 111 to 120 of about 1,682,340 (366)

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Measuring similarities between transcription factor binding sites

BMC Bioinformatics, 2005
Background Collections of transcription factor binding profiles (Transfac, Jaspar) are essential to identify regulatory elements in DNA sequences. Subsets of highly similar profiles complicate large scale analysis of transcription factor binding sites ...
Gonze Didier, Kielbasa Szymon M, Herzel Hanspeter   +2 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation [PDF]

, 2014
The force-dependent interaction between talin and vinculin plays a crucial role in the initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the mechano-sensitive compact N-terminal region of the talin rod, and show that
J. Yan (3377042), 陈虎, Yan, Jie, Sheetz, M.P., M. Yao (5803124), Cong, Peiwen, Yao, M, Goult, Benjamin T., Chen, H, Cong, P, Cong, P., Sheetz, Michael P., Goult, Benjamin T, M. P. Sheetz (7676465), Goult, BT, Sheetz, Michael P, Yan, J., P. Cong (7676462), Sheetz, MP, H. Chen (1500661), Yan, J, Goult, B.T., Chen, H., Yao, Mingxi, Chen, Hu, Yao, M., Benjamin T. Goult (173495)   +26 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

14-3-3-Pred:Improved methods to predict 14-3-3-binding phosphopeptides [PDF]

, 2015
Motivation: The 14-3-3 family of phosphoprotein-binding proteins regulate many cellular processes by docking onto pairs of phosphorylated Ser and Thr residues in a constellation of intracellular targets. Therefore, there is a pressing need to develop new
Murugesan, Gavuthami, Madeira, Fábio, Cole, Christian; id_orcid, Stafford, Margaret, Toth, Rachel, Barton, Geoffrey J.; id_orcid, Tinti, Michele, Berrett, Emily, MacKintosh, Carol; id_orcid   +8 more
core   +1 more source

Structure-Based Prediction of Transcription Factor Binding Sites

Tsinghua Science and Technology, 2014
Transcription Factors (TFs) are a very diverse family of DNA-binding proteins that play essential roles in the regulation of gene expression through binding to specific DNA sequences.
Jun-tao Guo, Shane Lofgren, Alvin Farrel
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

CLIPS-1D: Analysis of multiple sequence alignments to deduce for residue-positions a role in catalysis, ligand-binding, or protein structure [PDF]

, 2012
Background: One aim of the in silico characterization of proteins is to identify all residue-positions, which are crucial for function or structure. Several sequence-based algorithms exist, which predict functionally important sites.
Kück, Fabian, Rainer Merkl, Merkl, Rainer, Fabian Kück, Busch, Markus, Porfenenko, Mikhail, Mikhail Porfenenko, Merkl Rainer, Jan-Oliver Janda, Kück Fabian, Janda, Jan-Oliver, Porfenenko Mikhail, Janda Jan-Oliver, Busch Markus, Markus Busch   +14 more
core   +1 more source

Adaptive evolution of transcription factor binding sites

BMC Evolutionary Biology, 2004
Background The regulation of a gene depends on the binding of transcription factors to specific sites located in the regulatory region of the gene. The generation of these binding sites and of cooperativity between them are essential building blocks in ...
Berg Johannes, Willmann Stana, Lässig Michael   +2 more
doaj   +1 more source