Results 31 to 40 of about 1,682,340 (366)

Amyloid and Tau Positron Emission Tomography Imaging in Alzheimer’s Disease and Other Tauopathies

Frontiers in Aging Neuroscience, 2022
The detection and staging of Alzheimer’s disease (AD) using non-invasive imaging biomarkers is of substantial clinical importance. Positron emission tomography (PET) provides readouts to uncover molecular alterations in the brains of AD patients with ...
Cinzia Maschio, Ruiqing Ni, Ruiqing Ni
doaj   +1 more source

The Na+ Binding Site of Thrombin [PDF]

Journal of Biological Chemistry, 1995
Thrombin is an allosteric serine protease existing in two forms, slow and fast, targeted toward anticoagulant and procoagulant activities. The slow --> fast transition is induced by Na+ binding to a site contained within a cylindrical cavity formed by three antiparallel beta-strands of the B-chain (Met180-Tyr184a, Lys224-Tyr228, and Val213-Gly219 ...
E, Di Cera, E R, Guinto, A, Vindigni, Q D, Dang, Y M, Ayala, M, Wuyi, A, Tulinsky   +6 more
openaire   +2 more sources

Nucleotide-Binding Sites of the Heterodimeric LmrCD ABC-Multidrug Transporter of Lactococcus lactis Are Asymmetric [PDF]

, 2006
LmrCD is a lactococcal, heterodimeric multidrug transporter, which belongs to the ABC superfamily. It consists of two half-transporters, LmrC and LmrD, that are necessary and sufficient for drug extrusion and ATP hydrolysis.
Konings, Wil N., Lubelski, Jacek, Konings, Wil N.,, Merkerk, Ronald van, Lubelski, Jacek,, Merkerk, Ronald van,, Driessen, Arnold J.M.,, Driessen, Arnold J.M.   +7 more
core   +1 more source

BindingScanner: a tool for predicting binding sites of RNA-binding proteins in transcripts [PDF]

, 2020
BindingScanner is a tool for predicting binding sites of distinct regulators in an RNA sequence by calculating posterior probabilities with MotEvo, given the sequence specificity of regulators, represented as position-specific weight matrices.
Zavolan, Mihaela, Bak, Maciej, Kanitz, Alexander, Agarwal, Krish, Maciej Bak, Pachkov, Mikhail, Katsantoni, Maria   +6 more
core   +1 more source

Clinical, Genetic, and Protein Structural Aspects of Familial Dysalbuminemic Hyperthyroxinemia and Hypertriiodothyroninemia

Frontiers in Endocrinology, 2017
Familial dysalbuminemic hyperthyroxinemia (FDH-T4) and hypertriiodothyroninemia (FDH-T3) are dominantly inherited syndromes characterized by a high concentration of thyroid hormone in the blood stream.
Ulrich Kragh-Hansen, Monica Galliano, Lorenzo Minchiotti   +2 more
doaj   +1 more source

Automatic generation of 3D motifs for classification of protein binding sites [PDF]

, 2007
BACKGROUND: Since many of the new protein structures delivered by high-throughput processes do not have any known function, there is a need for structure-based prediction of protein function. Protein 3D structures can be clustered according to their fold
Herzyk, P, Herzyk, Pawel, Gilbert, D, Nebel, J, Gilbert, David R., Jean-Christophe Nebel, Herzyk, P., Gilbert, D.R., Nebel Jean-Christophe, Nebel, J.C., David R Gilbert, Gilbert David R, Nebel, Jean-Christophe, Pawel Herzyk, Herzyk Pawel   +14 more
core   +1 more source

Prediction of Functional Sites in SCOP Domains using Dynamics Perturbation Analysis [PDF]

, 2008
Dynamics perturbation analysis (DPA) finds regions in a protein structure where proteins are "ticklish", i.e., where interactions cause a large change in protein dynamics.
Michael E. Wall, Dengming Ming, Judith D. Cohn   +2 more
core   +2 more sources

Binding Sites of Anti-Lcr V Monoclonal Antibodies Are More Critical than the Avidities and Affinities for Passive Protection against Yersinia pestis Infection in a Bubonic Plague Model

Antibodies, 2020
Plague is a zoonotic disease that is caused by Yersinia pestis. Monoclonal antibodies (mAbs) that bind to the V-antigen, a virulence factor that is produced by Y. pestis, can passively protect mice from plague. An analysis of protective mAbs that bind to
Kei Amemiya, Jennifer L. Dankmeyer, Sarah L. Keasey, Sylvia R. Trevino, Michael M. Wormald, Stephanie A. Halasohoris, Wilson J. Ribot, David P. Fetterer, Christopher K. Cote, Patricia L. Worsham, Jeffrey J. Adamovicz, Robert G. Ulrich   +11 more
doaj   +1 more source

Prediction of Metal Ion Binding Sites in Proteins from Amino Acid Sequences by Using Simplified Amino Acid Alphabets and Random Forest Model [PDF]

Genomics & Informatics, 2017
Metal binding proteins or metallo-proteins are important for the stability of the protein and also serve as co-factors in various functions like controlling metabolism, regulating signal transport, and metal homeostasis.
Suresh Kumar
doaj   +1 more source

Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces [PDF]

, 2004
The regulators of complement activation (RCA) are critical to health and disease because their role is to ensure that a complement-mediated immune response to infection is proportionate and targeted.
Krystyna Bromek, Uhrin, D, O'Leary, JM, Xuefeng Wang, Stanislava Uhrinova, Joanne M. O'Leary, Black, GM, Wang, XF, Malgorzata Krych, John P. Atkinson, Uhrinova, S, Dusan Uhrin, Atkinson, JP, Gordon M. Black, Krych, M, Schmitz, C, Paul N. Barlow, Bromek, K, Barlow, PN, Christian Schmitz   +19 more
core   +1 more source