Results 31 to 40 of about 4,911,121 (311)

Clinical, Genetic, and Protein Structural Aspects of Familial Dysalbuminemic Hyperthyroxinemia and Hypertriiodothyroninemia

Frontiers in Endocrinology, 2017
Familial dysalbuminemic hyperthyroxinemia (FDH-T4) and hypertriiodothyroninemia (FDH-T3) are dominantly inherited syndromes characterized by a high concentration of thyroid hormone in the blood stream.
Ulrich Kragh-Hansen, Monica Galliano, Lorenzo Minchiotti   +2 more
doaj   +1 more source

Metal-ion binding and metal-ion induced folding of the adenine-sensing riboswitch aptamer domain [PDF]

, 2010
Divalent cations are important in the folding and stabilization of complex RNA structures. The adenine-sensing riboswitch controls the expression of mRNAs for proteins involved in purine metabolism by directly sensing intracellular adenine levels ...
Wöhnert, Jens, Schwalbe, Harald (Prof. Dr.), Noeske, Jonas   +2 more
core   +1 more source

Automatic generation of 3D motifs for classification of protein binding sites [PDF]

, 2007
BACKGROUND: Since many of the new protein structures delivered by high-throughput processes do not have any known function, there is a need for structure-based prediction of protein function. Protein 3D structures can be clustered according to their fold
Herzyk, P, Herzyk, Pawel, Gilbert, D, Nebel, J, Gilbert, David R., Jean-Christophe Nebel, Herzyk, P., Gilbert, D.R., Nebel Jean-Christophe, Nebel, J.C., David R Gilbert, Gilbert David R, Nebel, Jean-Christophe, Pawel Herzyk, Herzyk Pawel   +14 more
core   +1 more source

Binding Sites of Anti-Lcr V Monoclonal Antibodies Are More Critical than the Avidities and Affinities for Passive Protection against Yersinia pestis Infection in a Bubonic Plague Model

Antibodies, 2020
Plague is a zoonotic disease that is caused by Yersinia pestis. Monoclonal antibodies (mAbs) that bind to the V-antigen, a virulence factor that is produced by Y. pestis, can passively protect mice from plague. An analysis of protective mAbs that bind to
Kei Amemiya, Jennifer L. Dankmeyer, Sarah L. Keasey, Sylvia R. Trevino, Michael M. Wormald, Stephanie A. Halasohoris, Wilson J. Ribot, David P. Fetterer, Christopher K. Cote, Patricia L. Worsham, Jeffrey J. Adamovicz, Robert G. Ulrich   +11 more
doaj   +1 more source

Prediction of Metal Ion Binding Sites in Proteins from Amino Acid Sequences by Using Simplified Amino Acid Alphabets and Random Forest Model [PDF]

Genomics & Informatics, 2017
Metal binding proteins or metallo-proteins are important for the stability of the protein and also serve as co-factors in various functions like controlling metabolism, regulating signal transport, and metal homeostasis.
Suresh Kumar
doaj   +1 more source

Nucleotide-Binding Sites of the Heterodimeric LmrCD ABC-Multidrug Transporter of Lactococcus lactis Are Asymmetric [PDF]

, 2006
LmrCD is a lactococcal, heterodimeric multidrug transporter, which belongs to the ABC superfamily. It consists of two half-transporters, LmrC and LmrD, that are necessary and sufficient for drug extrusion and ATP hydrolysis.
Konings, Wil N., Lubelski, Jacek, Konings, Wil N.,, Merkerk, Ronald van, Lubelski, Jacek,, Merkerk, Ronald van,, Driessen, Arnold J.M.,, Driessen, Arnold J.M.   +7 more
core   +2 more sources

Discovery of Cisplatin Binding to Thymine and Cytosine on a Single-Stranded Oligodeoxynucleotide by High Resolution FT-ICR Mass Spectrometry

Molecules, 2019
The clinically widely-used anticancer drug, cisplatin, binds strongly to DNA as a DNA-damaging agent. Herein, we investigated the interaction of cisplatin with a 15-mer single-stranded C,T-rich oligodeoxynucleotide, 5′-CCTT4CTT7G8C9T10TCTCC-3′
Wenjuan Zeng, Yanyan Zhang, Wei Zheng, Qun Luo, Juanjuan Han, Jian’an Liu, Yao Zhao, Feifei Jia, Kui Wu, Fuyi Wang   +9 more
doaj   +1 more source

A client‐binding site of Cdc37 [PDF]

The FEBS Journal, 2005
The molecular chaperone Hsp90 is distinct from Hsp70 and chaperonin in that client proteins are apparently restricted to a subset of proteins categorized as cellular signaling molecules. Among these, many specific protein kinases require the assistance of Hsp90 and its co‐chaperone Cdc37/p50 for their biogenesis.
Kazuya, Terasawa, Yasufumi, Minami
openaire   +2 more sources

Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces [PDF]

, 2004
The regulators of complement activation (RCA) are critical to health and disease because their role is to ensure that a complement-mediated immune response to infection is proportionate and targeted.
Krystyna Bromek, Uhrin, D, O'Leary, JM, Xuefeng Wang, Stanislava Uhrinova, Joanne M. O'Leary, Black, GM, Wang, XF, Malgorzata Krych, John P. Atkinson, Uhrinova, S, Dusan Uhrin, Atkinson, JP, Gordon M. Black, Krych, M, Schmitz, C, Paul N. Barlow, Bromek, K, Barlow, PN, Christian Schmitz   +19 more
core   +1 more source

Structural Dynamics of DPP-4 and Its Influence on the Projection of Bioactive Ligands

Molecules, 2018
Dipeptidyl peptidase-4 (DPP-4) is a target to treat type II diabetes mellitus. Therefore, it is important to understand the structural aspects of this enzyme and its interaction with drug candidates.
Simone Queiroz Pantaleão, Eric Allison Philot, Pedro Túlio de Resende-Lara, Angélica Nakagawa Lima, David Perahia, Maria Atanassova Miteva, Ana Ligia Scott, Kathia Maria Honorio   +7 more
doaj   +1 more source