Divergence of the mRNA targets for the Ssb proteins of bacteriophages T4 and RB69
Virology Journal, 2004 The single-strand binding (Ssb) protein of phage T4 (T4 gp32, product of gene 32) is a mRNA-specific autogenous translational repressor, in addition to being a sequence-independent ssDNA-binding protein that participates in phage DNA replication, repair ...
Petrov Vasiliy M +2 more
doaj +1 more source
Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation. [PDF]
, 2015 Ets transcription factors, which share the conserved Ets DNA-binding domain, number nearly 30 members in humans and are particularly involved in developmental processes.
Allerston, Charles K. +4 more
core +1 more source
Identification of DNA-binding proteins using support vector machines and evolutionary profiles
BMC Bioinformatics, 2007 Background Identification of DNA-binding proteins is one of the major challenges in the field of genome annotation, as these proteins play a crucial role in gene-regulation.
Gromiha Michael M +2 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2023 The neurodegenerative and inflammatory illnesses of amyotrophic lateral sclerosis and multiple sclerosis were once thought to be completely distinct entities that did not share any remarkable features, but new research is beginning to reveal more ...
Isabel Acosta-Galeana +4 more
doaj +1 more source
Non-additivity in protein-DNA binding [PDF]
Bioinformatics, 2005 Localizing protein binding sites within genomic DNA is of considerable importance, but remains difficult for protein families, such as transcription factors, which have loosely defined target sequences. It is generally assumed that protein affinity for DNA involves additive contributions from successive nucleotide pairs within the target sequence. This
Ruadhan A. O'Flanagan +3 more
openaire +3 more sources
Versatile toolbox for high throughput biochemical and functional studies with fluorescent fusion proteins [PDF]
, 2012 Fluorescent fusion proteins are widely used to study protein localization and interaction dynamics in living cells. However, to fully characterize proteins and to understand their function it is crucial to determine biochemical characteristics such as ...
Sandra B. Hake (165089) +15 more
core +2 more sources
, 2021 Single-stranded DNA-binding proteins (SSBs) are essential to all living organisms as protectors and guardians of the genome. Apart from the well-characterized RPA, humans have also evolved two further SSBs, termed hSSB1 and hSSB2. Over the last few years,
Cubeddu, Liza (R16726) +9 more
core +1 more source
Site-specific DNA Mapping of Protein Binding Orientation Using Azidophenacyl Bromide (APB)
Bio-Protocol, 2020 The orientation of a DNA-binding protein bound on DNA is determinative in directing the assembly of other associated proteins in the complex for enzymatic action.
Himasha Perera, Michael Trakselis
doaj +1 more source
Analyzing the Surface Structure of the Binding Domain on DNA and RNA Binding Proteins
IEEE Access, 2019 The study of nucleic acid-binding protein (NBP) has important significance for us to understand critical intracellular activities, such as the transmission of cellular genetic information, cell metabolism, substance transport, and signal transduction ...
Wei Wang +6 more
doaj +1 more source
Single-stranded DNA binding proteins influence APOBEC3A substrate preference
Scientific Reports, 2021 The cytidine deaminase, APOBEC3A (A3A), is a prominent source of mutations in multiple cancer types. These APOBEC-signature mutations are non-uniformly distributed across cancer genomes, associating with single-stranded (ss) DNA formed during DNA ...
Amber L. Brown +5 more
doaj +1 more source