Results 41 to 50 of about 1,958,390 (304)
DNA-binding activity of papillomavirus proteins [PDF]
Journal of Virology, 1987 We demonstrate DNA binding by papillomavirus (PV) open reading frame (ORF) proteins that correspond to the early transforming and trans-activating (E6 and E2) and late structural regions (L2 and L1) from bovine PV type 1 and human PV types 6b and 16.
R G, Mallon +2 more
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Structural insights into the autoregulation and cooperativity of the human transcription factor Ets-2 [PDF]
, 2015 Ets-2, like its closely related homologue Ets-1, is a member of the Ets family of DNA binding transcription factors. Both proteins are subject to multiple levels of regulation of their DNA binding and transactivation properties.
Adams +33 more
core +1 more source
Calling cards for DNA-binding proteins [PDF]
Genome Research, 2007 Identifying genomic targets of transcription factors is fundamental for understanding transcriptional regulatory networks. Current technology enables identification of all targets of a single transcription factor, but there is no realistic way to achieve the converse: identification of all proteins that bind to a promoter of interest. We have developed
Wang, Haoyi +2 more
openaire +3 more sources
Molecules, 2019 Interactions between proteins and DNAs play essential roles in many biological processes. DNA binding proteins can be classified into two categories. Double-stranded DNA-binding proteins (DSBs) bind to double-stranded DNA and are involved in a series of ...
Changgeng Tan +3 more
doaj +1 more source
Using competition assays to quantitatively model cooperative binding by transcription factors and other ligands. [PDF]
, 2017 BACKGROUND: The affinities of DNA binding proteins for target sites can be used to model the regulation of gene expression. These proteins can bind to DNA cooperatively, strongly impacting their affinity and specificity.
Jaynes, James B, Peacock, Jacob
core +2 more sources
Evolutionary conservation of DNA-contact residues in DNA-binding domains
BMC Bioinformatics, 2008 Background DNA-binding proteins are of utmost importance to gene regulation. The identification of DNA-binding domains is useful for understanding the regulation mechanisms of DNA-binding proteins. In this study, we proposed a method to determine whether
Chen Yung-Chian +5 more
doaj +1 more source
Scientific Reports, 2021 Several DNA-binding proteins show the affinities for their specific DNA sites that positively depend on the length of DNA harboring the sites, i. e. antenna effect. DNA looping can cause the effect for proteins with two or more DNA binding sites, i.
Takashi Kinebuchi, Nobuo Shimamoto
doaj +1 more source
Stochastic Ratchet Mechanisms for Replacement of Proteins Bound to DNA [PDF]
, 2013 Experiments indicate that unbinding rates of proteins from DNA can depend on the concentration of proteins in nearby solution. Here we present a theory of multi-step replacement of DNA-bound proteins by solution-phase proteins. For four different kinetic
Cocco, Simona +2 more
core +3 more sources
PSSM-based prediction of DNA binding sites in proteins
BMC Bioinformatics, 2005 Background Detection of DNA-binding sites in proteins is of enormous interest for technologies targeting gene regulation and manipulation. We have previously shown that a residue and its sequence neighbor information can be used to predict DNA-binding ...
Ahmad Shandar, Sarai Akinori
doaj +1 more source
Methylated DNMT1 and E2F1 Are Targeted for Proteolysis by L3MBTL3 and CRL4DCAF5 Ubiquitin Ligase [PDF]
, 2018 Many non-histone proteins are lysine methylated and a novel function of this modification is to trigger the proteolysis of methylated proteins. Here, we report that the methylated lysine 142 of DNMT1, a major DNA methyltransferase that preserves ...
Alejo, Salvador +7 more
core +3 more sources