Results 51 to 60 of about 5,163,408 (306)

Turnover and function of DNA methylation at transcription factor binding sites [PDF]

, 2014
Cell type identity is largely determined by regulatory networks consistent of various transcription factors. Transcription factor activity requires interaction with DNA and thus critically depends on the accessibility of binding motifs.
Feldmann, Angelika
core   +1 more source

Evolutionary conservation of DNA-contact residues in DNA-binding domains

BMC Bioinformatics, 2008
Background DNA-binding proteins are of utmost importance to gene regulation. The identification of DNA-binding domains is useful for understanding the regulation mechanisms of DNA-binding proteins. In this study, we proposed a method to determine whether
Chen Yung-Chian, Kao Cheng-Yan, Tsai Huai-Kuang, Chang Yao-Lin, Hu Yuh-Jyh, Yang Jinn-Moon   +5 more
doaj   +1 more source

PredPSD: A Gradient Tree Boosting Approach for Single-Stranded and Double-Stranded DNA Binding Protein Prediction

Molecules, 2019
Interactions between proteins and DNAs play essential roles in many biological processes. DNA binding proteins can be classified into two categories. Double-stranded DNA-binding proteins (DSBs) bind to double-stranded DNA and are involved in a series of ...
Changgeng Tan, Tong Wang, Wenyi Yang, Lei Deng   +3 more
doaj   +1 more source

Chromosomal macrodomains and associated proteins : implications for DNA organization and replication in gram negative bacteria [PDF]

, 2011
The Escherichia coli chromosome is organized into four macrodomains, the function and organisation of which are poorly understood. In this review we focus on the MatP, SeqA, and SlmA proteins that have recently been identified as the first examples of ...
Kalmykowa, Olga J., Remus T. Dame, Kalmykowa, OJ, Dame Remus T., Grainger David C., Dame, Remus T. (Remus Thei), David C Grainger, Grainger, David, Kalmykowa Olga J., David C. Grainger, Dame, RT, Olga J Kalmykowa, Grainger, David C., Remus T Dame, Olga J. Kalmykowa   +14 more
core   +1 more source

Chromodomain helicase DNA-binding proteins and orofacial cleft

Journal of Research in Medical Sciences
Orofacial clefts (OFCs) are among the most common congenital anomalies, arising from a complex interplay of genetic and environmental factors that disrupt the precisely coordinated processes of craniofacial development.
Mehran Dehghanian, Majid Hosseinzadeh, Hossein Abdali, Nayereh Nouri, Mohammad Kazemi   +4 more
doaj   +1 more source

One-dimensional diffusion of TrpR along DNA enhances its affinity for the operator by chemical ratchet mechanism

Scientific Reports, 2021
Several DNA-binding proteins show the affinities for their specific DNA sites that positively depend on the length of DNA harboring the sites, i. e. antenna effect. DNA looping can cause the effect for proteins with two or more DNA binding sites, i.
Takashi Kinebuchi, Nobuo Shimamoto
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

An acidic region of the 89K murine cytomegalovirus immediate early protein interacts with DNA [PDF]

, 1992
The product of the ie 1 gene, the regulatory immediate early protein pp89 of murine cytomegalovirus (MCMV), interacts with core histones, which can mediate the association of pp89 with DNA.
Plachter, Bodo, Münch, Konrad, Koszinowski, Ulrich H., Messerle, Martin   +3 more
core   +1 more source

PSSM-based prediction of DNA binding sites in proteins

BMC Bioinformatics, 2005
Background Detection of DNA-binding sites in proteins is of enormous interest for technologies targeting gene regulation and manipulation. We have previously shown that a residue and its sequence neighbor information can be used to predict DNA-binding ...
Ahmad Shandar, Sarai Akinori
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source