Results 51 to 60 of about 5,403,999 (308)
Evolutionary conservation of DNA-contact residues in DNA-binding domains
BMC Bioinformatics, 2008 Background DNA-binding proteins are of utmost importance to gene regulation. The identification of DNA-binding domains is useful for understanding the regulation mechanisms of DNA-binding proteins. In this study, we proposed a method to determine whether
Chen Yung-Chian +5 more
doaj +1 more source
Molecules, 2019 Interactions between proteins and DNAs play essential roles in many biological processes. DNA binding proteins can be classified into two categories. Double-stranded DNA-binding proteins (DSBs) bind to double-stranded DNA and are involved in a series of ...
Changgeng Tan +3 more
doaj +1 more source
Interaction of the 89K murine cytomegalovirus immediate-early protein with core histones [PDF]
, 1988 The conditions that permit the interaction of immediate-early proteins of murine cytornegalovirus (MCMV) with DNA were studied. Chromatography of extracts from infected cells on MCMV DNA cellulose and calf thymus DNA cellulose showed that pp89, the ...
Münch, Konrad +3 more
core +1 more source
Scientific Reports, 2021 Several DNA-binding proteins show the affinities for their specific DNA sites that positively depend on the length of DNA harboring the sites, i. e. antenna effect. DNA looping can cause the effect for proteins with two or more DNA binding sites, i.
Takashi Kinebuchi, Nobuo Shimamoto
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain. [PDF]
, 2011 Recent discovery of 5-hydroxymethylcytosine (5hmC) in genomic DNA raises the question how this sixth base is recognized by cellular proteins. In contrast to the methyl-CpG binding domain (MBD) of MeCP2, we found that the SRA domain of Uhrf1, an essential
Frauer, C. +28 more
core +2 more sources
PSSM-based prediction of DNA binding sites in proteins
BMC Bioinformatics, 2005 Background Detection of DNA-binding sites in proteins is of enormous interest for technologies targeting gene regulation and manipulation. We have previously shown that a residue and its sequence neighbor information can be used to predict DNA-binding ...
Ahmad Shandar, Sarai Akinori
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Method of Detecting and Targeting Mutations in Cancer [PDF]
, 2007 While there are many differences between tumor and non-tumor cells, the basic underlying distinction is in the DNA. Tumor cells harbor mutations, at least some of which are not present in non-tumor cells.
Byard Edwards
core +1 more source
Luminescent detection of DNA-binding proteins [PDF]
Nucleic Acids Research, 2011 Transcription factors play a central role in cell development, differentiation and growth in biological systems due to their ability to regulate gene expression by binding to specific DNA sequences within the nucleus. The dysregulation of transcription factor signaling has been implicated in the pathogenesis of a number of cancers, developmental ...
Chan, DSH +5 more
openaire +4 more sources