Results 31 to 40 of about 1,668,835 (315)
Site-specific DNA Mapping of Protein Binding Orientation Using Azidophenacyl Bromide (APB)
Bio-Protocol, 2020 The orientation of a DNA-binding protein bound on DNA is determinative in directing the assembly of other associated proteins in the complex for enzymatic action.
Himasha Perera, Michael Trakselis
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Comparative footprinting of DNA-binding proteins [PDF]
Bioinformatics, 2006 Abstract Motivation: Comparative modelling is a computational method used to tackle a variety of problems in molecular biology and biotechnology. Traditionally it has been applied to model the structure of proteins on their own or bound to small ligands, although more recently it has also been used to model protein-protein interfaces ...
Bruno Contreras-Moreira +1 more
openaire +3 more sources
Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: Determinants of DNA Binding and Redox Regulation by Disulfide Bond Formation. [PDF]
, 2015 Ets transcription factors, which share the conserved Ets DNA-binding domain, number nearly 30 members in humans and are particularly involved in developmental processes.
Allerston, Charles K. +4 more
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Drosophila DNA-Binding Proteins in Polycomb Repression
Epigenomes, 2018 The formation of individual gene expression patterns in different cell types is required during differentiation and development of multicellular organisms.
Maksim Erokhin +2 more
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Frontiers in Molecular Neuroscience, 2023 The neurodegenerative and inflammatory illnesses of amyotrophic lateral sclerosis and multiple sclerosis were once thought to be completely distinct entities that did not share any remarkable features, but new research is beginning to reveal more ...
Isabel Acosta-Galeana +4 more
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Analyzing the Surface Structure of the Binding Domain on DNA and RNA Binding Proteins
IEEE Access, 2019 The study of nucleic acid-binding protein (NBP) has important significance for us to understand critical intracellular activities, such as the transmission of cellular genetic information, cell metabolism, substance transport, and signal transduction ...
Wei Wang +6 more
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Luminescent detection of DNA-binding proteins [PDF]
Nucleic Acids Research, 2011 Transcription factors play a central role in cell development, differentiation and growth in biological systems due to their ability to regulate gene expression by binding to specific DNA sequences within the nucleus. The dysregulation of transcription factor signaling has been implicated in the pathogenesis of a number of cancers, developmental ...
Chan, DSH +5 more
openaire +4 more sources
Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains [PDF]
, 2004 MBD1 is a vertebrate methyl-CpG binding domain protein (MBD) that can bring about repression of methylated promoter DNA sequences. Like other MBD proteins, MBD1 localizes to nuclear foci that in mice are rich in methyl-CpG.
Bird, Adrian P; id_orcid +2 more
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Apoptosis and DNA methylation [PDF]
, 2011 Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can ...
Meng, Huan X +18 more
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PLoS ONE, 2014 As more and more protein sequences are uncovered from increasingly inexpensive sequencing techniques, an urgent task is to find their functions. This work presents a highly reliable computational technique for predicting DNA-binding function at the level
Huiying Zhao +3 more
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