Results 31 to 40 of about 5,163,408 (306)
A second DNA binding site on RFC facilitates clamp loading at gapped or nicked DNA
eLife, 2022 Clamp loaders place circular sliding clamp proteins onto DNA so that clamp-binding partner proteins can synthesize, scan, and repair the genome. DNA with nicks or small single-stranded gaps are common clamp-loading targets in DNA repair, yet these ...
Xingchen Liu +3 more
doaj +1 more source
Comparative footprinting of DNA-binding proteins [PDF]
Bioinformatics, 2006 Abstract Motivation: Comparative modelling is a computational method used to tackle a variety of problems in molecular biology and biotechnology. Traditionally it has been applied to model the structure of proteins on their own or bound to small ligands, although more recently it has also been used to model protein-protein interfaces ...
Bruno Contreras-Moreira +1 more
openaire +4 more sources
Coarse-grained models of biomolecule dynamics and allostery [PDF]
, 2010 Recently, it has become increasingly accepted that thermal fluctuations take active part in functional tasks of biological molecules. We employ a set of coarse-grained models to investigate the mechanism of transmission of allosteric signal via spatial ...
Toncrova, Hedvika
core +7 more sources
Drosophila DNA-Binding Proteins in Polycomb Repression
Epigenomes, 2018 The formation of individual gene expression patterns in different cell types is required during differentiation and development of multicellular organisms.
Maksim Erokhin +2 more
doaj +1 more source
Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains [PDF]
, 2004 MBD1 is a vertebrate methyl-CpG binding domain protein (MBD) that can bring about repression of methylated promoter DNA sequences. Like other MBD proteins, MBD1 localizes to nuclear foci that in mice are rich in methyl-CpG.
Bird, Adrian P; id_orcid +2 more
core +1 more source
Comparison of histone-like HU protein DNA-binding properties and HU/IHF protein sequence alignment. [PDF]
PLoS ONE, 2017 The structure and function of bacterial nucleoid are controlled by histone-like proteins of HU/IHF family, omnipresent in bacteria and also founding archaea and some eukaryotes.HU protein binds dsDNA without sequence specificity and avidly binds DNA ...
Dmitri Kamashev +9 more
doaj +1 more source
Apoptosis and DNA methylation [PDF]
, 2011 Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can ...
Meng, Huan X +18 more
core +1 more source
PLoS ONE, 2014 As more and more protein sequences are uncovered from increasingly inexpensive sequencing techniques, an urgent task is to find their functions. This work presents a highly reliable computational technique for predicting DNA-binding function at the level
Huiying Zhao +3 more
doaj +1 more source
Bio-Protocol, 2021 In the cell, the thermodynamic stability of a protein – and hence its biological activity – can change dramatically as a result of perturbations in its amino acid sequence and the concentration of stabilizing ligands.
Jeung- Ha +3 more
doaj +1 more source
Acrylamide Capture of DNA-Bound Complexes: Electrophoretic Purification of Transcription Factors
BioTechniques, 2002 We have developed a rapid nonradioactive electrophoretic technique to analyze proteins within DNA-binding complexes, acrylamide capture of DNA-binding complexes (ACDC), using Acrydite™-linked DNA-binding targets. The method is highly sensitive and easily
Colleen Nelson +3 more
doaj +1 more source