Results 31 to 40 of about 1,665,524 (314)

Analyzing the Surface Structure of the Binding Domain on DNA and RNA Binding Proteins

IEEE Access, 2019
The study of nucleic acid-binding protein (NBP) has important significance for us to understand critical intracellular activities, such as the transmission of cellular genetic information, cell metabolism, substance transport, and signal transduction ...
Wei Wang, Keliang Li, Hehe Lv, Hongjun Zhang, Shiguang Zhang, Yun Zhou, Junwei Huang   +6 more
doaj   +1 more source

RNA-binding proteins as a common ground for neurodegeneration and inflammation in amyotrophic lateral sclerosis and multiple sclerosis

Frontiers in Molecular Neuroscience, 2023
The neurodegenerative and inflammatory illnesses of amyotrophic lateral sclerosis and multiple sclerosis were once thought to be completely distinct entities that did not share any remarkable features, but new research is beginning to reveal more ...
Isabel Acosta-Galeana, Ricardo Hernández-Martínez, Tania Reyes-Cruz, Erwin Chiquete, Jose de Jesus Aceves-Buendia   +4 more
doaj   +1 more source

Luminescent detection of DNA-binding proteins [PDF]

Nucleic Acids Research, 2011
Transcription factors play a central role in cell development, differentiation and growth in biological systems due to their ability to regulate gene expression by binding to specific DNA sequences within the nucleus. The dysregulation of transcription factor signaling has been implicated in the pathogenesis of a number of cancers, developmental ...
Chan, DSH, He, HZ, Cheng, Z, Yang, H, Leung, CH, Ma, DL   +5 more
openaire   +4 more sources

Apoptosis and DNA methylation [PDF]

, 2011
Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can ...
Meng, Huan X, Nestor, Colm, Reddington, James P, Richard R. Meehan, Harrison, David J, Dunican, Donncha S, Monika Madej, Hackett, James A, Dunican, Donncha S; id_orcid, James P. Reddington, Madej, Monika, Colm Nestor, Sari Pennings, Meehan, Richard R, Pennings, Sari, James A. Hackett, Huan X. Meng, David J. Harrison, Donncha S. Dunican   +18 more
core   +1 more source

Predicting DNA-binding proteins and binding residues by complex structure prediction and application to human proteome.

PLoS ONE, 2014
As more and more protein sequences are uncovered from increasingly inexpensive sequencing techniques, an urgent task is to find their functions. This work presents a highly reliable computational technique for predicting DNA-binding function at the level
Huiying Zhao, Jihua Wang, Yaoqi Zhou, Yuedong Yang   +3 more
doaj   +1 more source

Comparison of histone-like HU protein DNA-binding properties and HU/IHF protein sequence alignment. [PDF]

PLoS ONE, 2017
The structure and function of bacterial nucleoid are controlled by histone-like proteins of HU/IHF family, omnipresent in bacteria and also founding archaea and some eukaryotes.HU protein binds dsDNA without sequence specificity and avidly binds DNA ...
Dmitri Kamashev, Yulia Agapova, Sergey Rastorguev, Anna A Talyzina, Konstantin M Boyko, Dmitry A Korzhenevskiy, Anna Vlaskina, Raif Vasilov, Vladimir I Timofeev, Tatiana V Rakitina   +9 more
doaj   +1 more source

Urea Denaturation, Zinc Binding, and DNA Binding Assays of Mutant p53 DNA-binding Domains and Full-length Proteins

Bio-Protocol, 2021
In the cell, the thermodynamic stability of a protein – and hence its biological activity – can change dramatically as a result of perturbations in its amino acid sequence and the concentration of stabilizing ligands.
Jeung- Ha, Xin Yu, Darren Carpizo, Stewart Loh   +3 more
doaj   +1 more source

Acrylamide Capture of DNA-Bound Complexes: Electrophoretic Purification of Transcription Factors

BioTechniques, 2002
We have developed a rapid nonradioactive electrophoretic technique to analyze proteins within DNA-binding complexes, acrylamide capture of DNA-binding complexes (ACDC), using Acrydite™-linked DNA-binding targets. The method is highly sensitive and easily
Colleen Nelson, Stephen Hendy, Kim Reid, John Cavanagh   +3 more
doaj   +1 more source

Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos. [PDF]

PLoS Biology, 2009
Polycomb group (PcG) and trithorax group (trxG) proteins are conserved chromatin factors that regulate key developmental genes throughout development.
Bernd Schuettengruber, Mythily Ganapathi, Benjamin Leblanc, Manuela Portoso, Rami Jaschek, Bas Tolhuis, Maarten van Lohuizen, Amos Tanay, Giacomo Cavalli   +8 more
doaj   +1 more source

Pasteurellaceae ComE1 proteins combine the properties of fibronectin adhesins and DNA binding competence proteins.

PLoS ONE, 2008
A novel fibronectin-binding protein from Pasteurella multocida (PM1665) that binds to the fibronectin type III(9-10) modules via two helix-hairpin-helix motifs has recently been described [1].
Lisa M Mullen, Janine T Bossé, Sean P Nair, John M Ward, Andrew N Rycroft, Giles Robertson, Paul R Langford, Brian Henderson   +7 more
doaj   +1 more source