Results 31 to 40 of about 5,403,999 (308)

Comparative footprinting of DNA-binding proteins [PDF]

Bioinformatics, 2006
Abstract Motivation: Comparative modelling is a computational method used to tackle a variety of problems in molecular biology and biotechnology. Traditionally it has been applied to model the structure of proteins on their own or bound to small ligands, although more recently it has also been used to model protein-protein interfaces ...
Bruno Contreras-Moreira, Julio Collado-Vides   +1 more
openaire   +4 more sources

Apoptosis and DNA methylation [PDF]

, 2011
Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can ...
Meng, Huan X, Nestor, Colm, Reddington, James P, Richard R. Meehan, Harrison, David J, Dunican, Donncha S, Monika Madej, Hackett, James A, Dunican, Donncha S; id_orcid, James P. Reddington, Madej, Monika, Colm Nestor, Sari Pennings, Meehan, Richard R, Pennings, Sari, James A. Hackett, Huan X. Meng, David J. Harrison, Donncha S. Dunican, Harrison, David J; id_orcid   +19 more
core   +1 more source

Drosophila DNA-Binding Proteins in Polycomb Repression

Epigenomes, 2018
The formation of individual gene expression patterns in different cell types is required during differentiation and development of multicellular organisms.
Maksim Erokhin, Pavel Georgiev, Darya Chetverina   +2 more
doaj   +1 more source

Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains [PDF]

, 2004
MBD1 is a vertebrate methyl-CpG binding domain protein (MBD) that can bring about repression of methylated promoter DNA sequences. Like other MBD proteins, MBD1 localizes to nuclear foci that in mice are rich in methyl-CpG.
Bird, Adrian P; id_orcid, Jørgensen, Helle F, Ben-Porath, Ittai   +2 more
core   +1 more source

Predicting DNA-binding proteins and binding residues by complex structure prediction and application to human proteome.

PLoS ONE, 2014
As more and more protein sequences are uncovered from increasingly inexpensive sequencing techniques, an urgent task is to find their functions. This work presents a highly reliable computational technique for predicting DNA-binding function at the level
Huiying Zhao, Jihua Wang, Yaoqi Zhou, Yuedong Yang   +3 more
doaj   +1 more source

Urea Denaturation, Zinc Binding, and DNA Binding Assays of Mutant p53 DNA-binding Domains and Full-length Proteins

Bio-Protocol, 2021
In the cell, the thermodynamic stability of a protein – and hence its biological activity – can change dramatically as a result of perturbations in its amino acid sequence and the concentration of stabilizing ligands.
Jeung- Ha, Xin Yu, Darren Carpizo, Stewart Loh   +3 more
doaj   +1 more source

Dimer-dimer stacking interactions are important for nucleic acid binding by the archaeal chromatin protein Alba [PDF]

, 2010
Archaea use a variety of small basic proteins to package their DNA. One of the most widespread and highly conserved is the Alba (Sso10b) protein. Alba interacts with both DNA and RNA in vitro, and we show in the present study that it binds more tightly ...
Petrovic-Stojanovska, Biljana, White, Malcolm F, Jelinska, Clare, Ingledew, W John, Ingledew, William John, White, Malcolm F; id_orcid   +5 more
core   +1 more source

Coarse-grained models of biomolecule dynamics and allostery [PDF]

, 2010
Recently, it has become increasingly accepted that thermal fluctuations take active part in functional tasks of biological molecules. We employ a set of coarse-grained models to investigate the mechanism of transmission of allosteric signal via spatial ...
Toncrova, Hedvika
core   +4 more sources

An acidic region of the 89K murine cytomegalovirus immediate early protein interacts with DNA [PDF]

, 1992
The product of the ie 1 gene, the regulatory immediate early protein pp89 of murine cytomegalovirus (MCMV), interacts with core histones, which can mediate the association of pp89 with DNA.
Plachter, Bodo, Münch, Konrad, Koszinowski, Ulrich H., Messerle, Martin   +3 more
core   +1 more source

DNABP: Identification of DNA-Binding Proteins Based on Feature Selection Using a Random Forest and Predicting Binding Residues.

PLoS ONE, 2016
DNA-binding proteins are fundamentally important in cellular processes. Several computational-based methods have been developed to improve the prediction of DNA-binding proteins in previous years.
Xin Ma, Jing Guo, Xiao Sun
doaj   +1 more source