Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells [PDF]
Stem Cell Research & Therapy, 2017 Background Human dental mesenchymal stem cells (MSCs) are considered as highly accessible and attractive MSCs for use in regenerative medicine, yet some of their features are not as well characterized as other MSCs.
Victor G. Martinez +8 more
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Microarray analysis of pathways involved in bladder cancer invasion and metastasis. [PDF]
, 2008 MDHypoxia-inducible genes have been linked to the aggressive phenotype of cancer. However, nearly all work on hypoxia-regulated genes has been conducted in vitro on cell lines.
Ord, Jonathan J
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The possible role of hypoxia in the affected tissue of relapsed clubfoot
Scientific Reports, 2022 Our aim was to study the expression of hypoxia-related proteins as a possible regulatory pathway in the contracted side tissue of relapsed clubfoot. We compared the expression of hypoxia-related proteins in the tissue of the contracted (medial) side of ...
Tomas Novotny +9 more
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Frontiers in Cell and Developmental Biology, 2021 ObjectivesComplement 1q binding protein (C1QBP/HABP1/p32/gC1qR) has been found to be overexpressed in triple-negative breast cancer (TNBC). However, the underlying mechanisms of high C1QBP expression and its role in TNBC remain largely unclear.
Hao Wu +31 more
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Hypoxia and the hypoxia inducible factor 1α activate protein kinase A by repressing RII beta subunit transcription [PDF]
Oncogene, 2020 AbstractOveractivation of the cAMP signal transduction pathway plays a central role in the pathogenesis of endocrine tumors. Genetic aberrations leading to increased intracellular cAMP or directly affecting PKA subunit expression have been identified in inherited and sporadic endocrine tumors, but are rare indicating the presence of nongenomic ...
Lucia, Kristin +8 more
openaire +5 more sources
Inhibiting miR-155 protects against myocardial ischemia/reperfusion injury via targeted regulation of HIF-1α in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): The aim of this study was to identify the role of miR-155 in the myocardial ischemia/reperfusion (I/R) injury through targeting hypoxia-inducible factor 1-alpha (HIF-1α).
Jian-Guo Chen +3 more
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Regulation of the SIAH2-HIF-1 Axis by Protein Kinases and Its Implication in Cancer Therapy
Frontiers in Cell and Developmental Biology, 2021 The cellular response to hypoxia is a key biological process that facilitates adaptation of cells to oxygen deprivation (hypoxia). This process is critical for cancer cells to adapt to the hypoxic tumor microenvironment resulting from rapid tumor growth.
Dazhong Xu, Cen Li
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Can HIF-1 Alpha (Hypoxia- inducible factor-1 alpha) be a New Cardiac Hypoxia Marker in Acute Coronary Ischemia? [PDF]
, 2021 Objective:Hypoxia- inducible factor-1 alpha (HIF-1 alpha) is a gene protein whose activation is a primary defensive mechanism against tissue hypoxia. It is the main regulator of cellular oxygen delivery and consumption.
Feray Akbaş +2 more
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Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship
Molecular Cancer, 2023 Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone microenvironment where Ewing sarcoma (EwS) – a highly aggressive pediatric cancer – mainly arises. Hypoxia
A. Katharina Ceranski +5 more
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Frontiers in Oncology, 2023 BackgroundHypoxia-inducible factor 1-alpha (HIF-1α) stability and transcriptional action are reduced by the hypoxia-inducible factor 1-alpha subunit suppressor (HIF1AN). Its inappropriate expression is associated with the development of cancer and immune
Shasha Tang +8 more
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