Results 11 to 20 of about 35,931 (278)

Contribution of hypoxia inducible factor-1 during viral infections

Virulence, 2020
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs ...
Antonia Reyes, Nicolás Corrales, Nicolás M. S. Gálvez, Susan M. Bueno, Alexis M. Kalergis, Pablo A. González   +5 more
doaj   +2 more sources

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.

The Journal of biological chemistry, 1998
Hypoxia-inducible expression has been demonstrated for many groups of mammalian genes, and studies of transcriptional control have revealed the existence of hypoxia-responsive elements (HREs) in the cis-acting sequences of several of these genes. These sequences generally contain one or more binding sites for a heterodimeric DNA binding complex termed ...
Wood, S, Wiesener, MS, Yeates, K, Okada, N, Pugh, C, Maxwell, P, Ratcliffe, P   +6 more
openaire   +4 more sources

Effect of melatonin on steroidogenesis-related enzymes expression and testosterone synthesis following CoCl2-induced hypoxia in TM3 Leydig cells [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): This study examined the effects of melatonin treatment on steroidogenesis dysfunction and testosterone impairment, following CoCl2-induced hypoxia in TM3 Leydig cells. Materials and Methods: The TM3 cells were divided into four groups.
shokooh karimi, Cyrus Jalili, Kamran Mansouri, Fariborz Bahremand, Mohammadreza Gholami   +4 more
doaj   +1 more source

The possible role of hypoxia in the affected tissue of relapsed clubfoot

Scientific Reports, 2022
Our aim was to study the expression of hypoxia-related proteins as a possible regulatory pathway in the contracted side tissue of relapsed clubfoot. We compared the expression of hypoxia-related proteins in the tissue of the contracted (medial) side of ...
Tomas Novotny, Adam Eckhardt, Martina Doubkova, Jarmila Knitlova, David Vondrasek, Eliska Vanaskova, Martin Ostadal, Jiri Uhlik, Lucie Bacakova, Jana Musilkova   +9 more
doaj   +1 more source

Hypoxia-Mediated Complement 1q Binding Protein Regulates Metastasis and Chemoresistance in Triple-Negative Breast Cancer and Modulates the PKC-NF-κB-VCAM-1 Signaling Pathway

Frontiers in Cell and Developmental Biology, 2021
ObjectivesComplement 1q binding protein (C1QBP/HABP1/p32/gC1qR) has been found to be overexpressed in triple-negative breast cancer (TNBC). However, the underlying mechanisms of high C1QBP expression and its role in TNBC remain largely unclear.
Hao Wu, Hao Wu, Hao Wu, Yijun Chu, Yijun Chu, Yijun Chu, Shanshan Sun, Shanshan Sun, Shanshan Sun, Guozheng Li, Guozheng Li, Guozheng Li, Shouping Xu, Shouping Xu, Shouping Xu, Xianyu Zhang, Xianyu Zhang, Xianyu Zhang, Yongdong Jiang, Yongdong Jiang, Yongdong Jiang, Song Gao, Song Gao, Song Gao, Qin Wang, Qin Wang, Qin Wang, Jian Zhang, Da Pang, Da Pang, Da Pang, Da Pang   +31 more
doaj   +1 more source

Hypoxia and the hypoxia inducible factor 1α activate protein kinase A by repressing RII beta subunit transcription [PDF]

Oncogene, 2020
AbstractOveractivation of the cAMP signal transduction pathway plays a central role in the pathogenesis of endocrine tumors. Genetic aberrations leading to increased intracellular cAMP or directly affecting PKA subunit expression have been identified in inherited and sporadic endocrine tumors, but are rare indicating the presence of nongenomic ...
Lucia, Kristin, Wu, Yonghe, Monteserin Garcia, Jose, Barlier, Anne, Buchfelder, Michael, Saeger, Wolfgang, Renner, Ulrich, Stalla, Guenter K., Theodoropoulou, Marily   +8 more
openaire   +5 more sources

Regulation of the SIAH2-HIF-1 Axis by Protein Kinases and Its Implication in Cancer Therapy

Frontiers in Cell and Developmental Biology, 2021
The cellular response to hypoxia is a key biological process that facilitates adaptation of cells to oxygen deprivation (hypoxia). This process is critical for cancer cells to adapt to the hypoxic tumor microenvironment resulting from rapid tumor growth.
Dazhong Xu, Cen Li
doaj   +1 more source

Inhibiting miR-155 protects against myocardial ischemia/reperfusion injury via targeted regulation of HIF-1α in rats [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): The aim of this study was to identify the role of miR-155 in the myocardial ischemia/reperfusion (I/R) injury through targeting hypoxia-inducible factor 1-alpha (HIF-1α).
Jian-Guo Chen, Xiao-Ming Xu, Hui Ji, Bo Sun   +3 more
doaj   +1 more source

Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship

Molecular Cancer, 2023
Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone microenvironment where Ewing sarcoma (EwS) – a highly aggressive pediatric cancer – mainly arises. Hypoxia
A. Katharina Ceranski, Martha J. Carreño-Gonzalez, Anna C. Ehlers, Maria Vittoria Colombo, Florencia Cidre-Aranaz, Thomas G. P. Grünewald   +5 more
doaj   +1 more source

Low expression of HIF1AN accompanied by less immune infiltration is associated with poor prognosis in breast cancer

Frontiers in Oncology, 2023
BackgroundHypoxia-inducible factor 1-alpha (HIF-1α) stability and transcriptional action are reduced by the hypoxia-inducible factor 1-alpha subunit suppressor (HIF1AN). Its inappropriate expression is associated with the development of cancer and immune
Shasha Tang, Dongyang Liu, Yuan Fang, Liyun Yong, Yi Zhang, Mengying Guan, Xiaoyan Lin, Hui Wang, Fengfeng Cai   +8 more
doaj   +1 more source