Results 11 to 20 of about 35,236 (235)

The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis [PDF]

BMC Cancer, 2019
Background The rs2057482 polymorphism in the hypoxia inducible factor 1 subunit alpha (HIF1A) gene has been reported to be associated with a risk of several types of cancer, but this association has not yet been definitively confirmed.
Li-Fang Wu, Gui-Ping Xu, Qing Zhao, Li-Jing Zhou, Ding Wang, Wei-Xian Chen   +5 more
doaj   +3 more sources

Hypoxia inducible factor 1 subunit alpha mediates autophagy disorder of oral lichen planus by regulating lysosomal pathway

Frontiers in Immunology
Oral lichen planus (OLP), known as a common and chronic mucosal inflammatory disease. Due to its potential for cancerous transformation, this disease has long been a subject of significant concern.
Xie Li, Xie Li, Chao Han, Chao Han, Yuemei Yao, Yuemei Yao, Yuanxin Shi, Bin Chen, Yi Xiao, Yi Xiao, Guohui Bai   +10 more
doaj   +2 more sources

Long non-coding RNA COL4A2-AS1 facilitates cell proliferation and glycolysis of colorectal cancer cells via miR-20b-5p/hypoxia inducible factor 1 alpha subunit axis. [PDF]

Bioengineered, 2021
Long non-coding RNAs (lncRNAs) have critical functions in tumorigenesis and progression of colorectal cancer (CRC). The role of lncRNA COL4A2-AS1 (COL4A2-AS1) lacks system investigation. The current study comprehensively analyzed the expression, biological functions, and mechanism of COL4A2-AS1 in CRC through performing real-time quantitative PCR (RT ...
Yu Z, Wang Y, Deng J, Liu D, Zhang L, Shao H, Wang Z, Zhu W, Zhao C, Ke Q.   +9 more
europepmc   +4 more sources

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit [PDF]

Journal of Biological Chemistry, 1997
Hypoxia-inducible factor-1 (HIF-1), a heterodimeric DNA binding complex composed of two basic-helix-loop-helix Per-AHR-ARNT-Sim proteins (HIF-1alpha and -1beta), is a key component of a widely operative transcriptional response activated by hypoxia, cobaltous ions, and iron chelation.
Pugh, C, O'Rourke, J, Nagao, M, Gleadle, J, Ratcliffe, P   +4 more
openaire   +3 more sources

Hypoxia and the hypoxia inducible factor 1α activate protein kinase A by repressing RII beta subunit transcription [PDF]

Oncogene, 2020
AbstractOveractivation of the cAMP signal transduction pathway plays a central role in the pathogenesis of endocrine tumors. Genetic aberrations leading to increased intracellular cAMP or directly affecting PKA subunit expression have been identified in inherited and sporadic endocrine tumors, but are rare indicating the presence of nongenomic ...
Lucia, Kristin, Wu, Yonghe, Monteserin Garcia, Jose, Barlier, Anne, Buchfelder, Michael, Saeger, Wolfgang, Renner, Ulrich, Stalla, Guenter K., Theodoropoulou, Marily   +8 more
openaire   +5 more sources

Effects of moderate-intensity intermittent hypoxic training on health outcomes of patients recovered from COVID-19: the AEROBICOVID study protocol for a randomized controlled trial

Trials, 2021
Background Recent studies point to a lower number and reduced severity of cases in higher altitude cities with decreased oxygen concentration. Specific literature has shown several benefits of physical training, so, in this sense, physical training with ...
Átila Alexandre Trapé, Marta Camacho-Cardenosa, Alba Camacho-Cardenosa, Eugenio Merellano-Navarro, Jhennyfer Aline Lima Rodrigues, Elisangela Aparecida da Silva Lizzi, Carlos Arterio Sorgi, Marcelo Papoti, Javier Brazo-Sayavera   +8 more
doaj   +1 more source

Claudin-5 Affects Endothelial Autophagy in Response to Early Hypoxia

Frontiers in Physiology, 2021
Hypoxic injury to cerebrovascular endothelial cells (ECs) after stroke leads to blood-brain barrier (BBB) dysfunction, which is commonly associated with disruptions of endothelial tight junctions (TJs) and increased permeability.
Ping Yu, Yanyu Li, Gaoliang Zhong, Wen Li, Bing Chen, Jingjing Zhang   +5 more
doaj   +1 more source

Long Non-Coding RNA MEG8 Suppresses Hypoxia-Induced Excessive Proliferation, Migration and Inflammation of Vascular Smooth Muscle Cells by Regulation of the miR-195-5p/RECK Axis

Frontiers in Molecular Biosciences, 2021
It has been recognized that rebalancing the abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) helps relieve vascular injury.
Dexing Xu, Ruozhu Dai, Hao Chi, Wen Ge, Jingfeng Rong   +4 more
doaj   +1 more source

Eukaryotic initiation factor 5A2 mediates hypoxia-induced autophagy and cisplatin resistance

Cell Death and Disease, 2022
Hypoxia-induced cisplatin resistance is a major challenge during non-small cell lung cancer (NSCLC) treatment. Based on previous studies, we further explored the effect of eukaryotic initiation factor 5A2 (eIF5A2) in hypoxia-induced cisplatin resistance.
Guodong Xu, Hang Chen, Shibo Wu, Jiabin Chen, Shufen Zhang, Guofeng Shao, Lebo Sun, Yinyu Mu, Kaitai Liu, Qiaoling Pan, Ni Li, Xiaoxia An, Shuang Lin, Wei Chen   +13 more
doaj   +1 more source

Transforming Growth Factor-beta 1 Involved in the Pathogenesis of Endometriosis through Regulating Expression of Vascular Endothelial Growth Factor under Hypoxia

Chinese Medical Journal, 2017
Background: Endometriosis (EMs) is a common gynecological disorder characterized by endometrial-like tissue outside the uterus. Hypoxia induces the expression of many important downstream genes to regulate the implantation, survival, and maintenance of ...
Yue-Xin Yu, Yin-Ling Xiu, Xi Chen, Ya-Li Li   +3 more
doaj   +1 more source