Results 21 to 30 of about 33,359,923 (277)

Effects of moderate-intensity intermittent hypoxic training on health outcomes of patients recovered from COVID-19: the AEROBICOVID study protocol for a randomized controlled trial

Trials, 2021
Background Recent studies point to a lower number and reduced severity of cases in higher altitude cities with decreased oxygen concentration. Specific literature has shown several benefits of physical training, so, in this sense, physical training with ...
Átila Alexandre Trapé, Marta Camacho-Cardenosa, Alba Camacho-Cardenosa, Eugenio Merellano-Navarro, Jhennyfer Aline Lima Rodrigues, Elisangela Aparecida da Silva Lizzi, Carlos Arterio Sorgi, Marcelo Papoti, Javier Brazo-Sayavera   +8 more
doaj   +1 more source

Claudin-5 Affects Endothelial Autophagy in Response to Early Hypoxia

Frontiers in Physiology, 2021
Hypoxic injury to cerebrovascular endothelial cells (ECs) after stroke leads to blood-brain barrier (BBB) dysfunction, which is commonly associated with disruptions of endothelial tight junctions (TJs) and increased permeability.
Ping Yu, Yanyu Li, Gaoliang Zhong, Wen Li, Bing Chen, Jingjing Zhang   +5 more
doaj   +1 more source

Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells [PDF]

, 2011
DEAD box protein, DDX3, is aberrantly expressed in breast cancer cells ranging from weakly invasive to aggressive phenotypes and functions as an important regulator of cancer cell growth and survival.
Krishnamachary, B., Guus M. Bol, Paul T Winnard, Paul T. Winnard, Vesuna, F., Patel, A.H., Botlagunta, M., Mahendran Botlagunta, Farhad Vesuna, Ramanathan, V., Venu Raman, Arvind H Patel, Arvind H. Patel, Winnard, P.T., Bol, G.M., Guus M Bol, Balaji Krishnamachary   +16 more
core   +1 more source

Long Non-Coding RNA MEG8 Suppresses Hypoxia-Induced Excessive Proliferation, Migration and Inflammation of Vascular Smooth Muscle Cells by Regulation of the miR-195-5p/RECK Axis

Frontiers in Molecular Biosciences, 2021
It has been recognized that rebalancing the abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) helps relieve vascular injury.
Dexing Xu, Ruozhu Dai, Hao Chi, Wen Ge, Jingfeng Rong   +4 more
doaj   +1 more source

Effects of Stem Cell Factor on Hypoxia-Inducible Factor 1 Alpha Accumulation in Human Acute Myeloid Leukaemia and LAD2 Mast Cells [PDF]

, 2011
Stem cell factor (SCF) is a hematopoietic growth factor that exerts its activity by signalling through the tyrosine kinase receptor known as Kit or CD117.
Bernhard F. Gibbs, Sumbayev, Vadim V., Yasinska, Inna M., Gibbs, Bernhard F., Vadim V. Sumbayev, Inna M Yasinska, Abraham E. Oniku, Vadim V Sumbayev, Oniku, Abraham E., Bernhard F Gibbs, Abraham E Oniku, Inna M. Yasinska   +11 more
core   +2 more sources

Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens [PDF]

, 2010
Background: Hypoxia inducible factor (HIF)-1 is the key transcriptional factor involved in the adaptation process of cells and organisms to hypoxia. Recent findings suggest that HIF-1 plays also a crucial role in inflammatory and infectious diseases ...
Peschel, Andreas, Edelmann, Markus, Schäfer, Andrea, Werth Nadine, Andreas Peschel, Volkhard A. J. Kempf, Edelmann Markus, Yazdi Amir S., Becker, Karsten, Rosenberger, Christian, Nadine Werth, Amir S Yazdi, Volkhard A J Kempf, Bernhardt Wanja, Kempf, Volkhard A. J., Amr, Amro, Rosenberger Christian, Amr Amro, Werth, Nadine, Andrea Schäfer, Peschel Andreas, von Eiff Christof, Christiane Beerlage, Kempf Volkhard A. J., Eiff, Christof von, Amro Amr, Becker Karsten, Beerlage, Christiane, Christof von Eiff, Wanja Bernhardt, Yazdi, Amir Sadegh, Bernhardt, Wanja, Christian Rosenberger, Karsten Becker, Schäfer Andrea, Beerlage Christiane, Amir S. Yazdi, Markus Edelmann   +37 more
core   +2 more sources

Eukaryotic initiation factor 5A2 mediates hypoxia-induced autophagy and cisplatin resistance

Cell Death and Disease, 2022
Hypoxia-induced cisplatin resistance is a major challenge during non-small cell lung cancer (NSCLC) treatment. Based on previous studies, we further explored the effect of eukaryotic initiation factor 5A2 (eIF5A2) in hypoxia-induced cisplatin resistance.
Guodong Xu, Hang Chen, Shibo Wu, Jiabin Chen, Shufen Zhang, Guofeng Shao, Lebo Sun, Yinyu Mu, Kaitai Liu, Qiaoling Pan, Ni Li, Xiaoxia An, Shuang Lin, Wei Chen   +13 more
doaj   +1 more source

Responses to hypoxia via mTOR : role in endothelial cell proliferation and HIF-1[alpha] stabilization [PDF]

, 2005
Ischemic cardiovascular disease and cancer are life-threatening disorders in human mortality. Intensive studies on the etiology of and therapeutics for the diseases are ongoing.
Li, Weimin
core   +1 more source

Involvement of Hypoxia-Inducible Factor-1 in the Inflammatory Responses of Human LAD2 Mast Cells and Basophils [PDF]

, 2012
We recently showed that hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the pro-allergic functions of human basophils by transcriptional control of energy metabolism via glycolysis as well as directly triggering expression of the angiogenic ...
Claire L Streatfield, Sumbayev, Vadim V., Yasinska, Inna M., Gibbs, Bernhard F., Streatfield, Claire L., Vadim V Sumbayev, Oniku, Abraham E., Bernhard F Gibbs, Streatfield Claire L., Yasinska Inna, Sumbayev Vadim V., Inna Yasinska, Oniku Abraham E., Gibbs Bernhard F., Abraham E Oniku   +14 more
core   +2 more sources

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]

, 2013
BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
Wann, AK, Wann, Angus K.T., Chapple, JP, Knight, MM, Knight, Martin M., Thompson, CL, Thompson, Clare L., Chapple, J. Paul   +7 more
core   +1 more source