A Retrospective on eIF2A-and Not the Alpha Subunit of eIF2. [PDF]
Int J Mol Sci, 2020 Initiation of protein synthesis in eukaryotes is a complex process requiring more than 12 different initiation factors, comprising over 30 polypeptide chains. The functions of many of these factors have been established in great detail; however, the precise role of some of them and their mechanism of action is still not well understood.
Komar AA, Merrick WC.
europepmc +4 more sources
Characterisation of the tryptophan synthase alpha subunit in maize [PDF]
BMC Plant Biology, 2008 Background In bacteria, such as Salmonella typhimurium, tryptophan is synthesized from indole-3-glycerole phosphate (IGP) by a tryptophan synthase αββα heterotetramer.
Gierl Alfons +6 more
doaj +3 more sources
Inherited/Genetically-Associated Pheochromocytoma/ Paraganglioma Syndromes and COVID-19
Medicina, 2021 In some subjects with inherited pheochromocytoma/paraganglioma (PPG) syndromes, hypoxia-inducible factor 1 alpha (HIF1α) stabilization/activation could lead to an increase in angiotensin converting enzymes (ACE).
Ioannis Ilias +3 more
doaj +1 more source
Genetic epilepsy with febrile seizures plus – an overview [PDF]
Romanian Journal of Neurology, 2021 Genetic epilepsy with febrile seizures plus (GEFS+) is characterized by a group of genetic epilepsies associated predominately with an autosomal dominant pattern, but also with de novo and autosomal-recessive inheritance, these last two found in a small ...
Madalina Radu +3 more
doaj +1 more source
PLoS ONE, 2021 BackgroundThe IgE-mediated activation of mast cells and basophils results in the secretion of many substances, including the release of FceRI-alpha subunit.
Donald MacGlashan
doaj +1 more source
A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization. [PDF]
PLoS ONE, 2016 The heteromeric membrane protein Organic Solute Transporter alpha/beta is the major bile acid efflux transporter in the intestine. Physical association of its alpha and beta subunits is essential for their polarized basolateral membrane localization and ...
Shuhua Xu +6 more
doaj +1 more source
G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits. [PDF]
Proceedings of the National Academy of Sciences, 1991 Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) are central to the signaling processes of multicellular organisms. We have explored the diversity of the G protein subunits in mammals and found evidence for a large family of genes that encode the alpha subunits.
M P, Strathmann, M I, Simon
openaire +2 more sources
Cannabidiol attenuates lung ischemia-reperfusion injury by modulating RIPK1/RIPK3-mediated necroptosis and HIF-1α/VEGF signaling [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Lung ischemia-reperfusion (IR) injury is a critical clinical condition characterized by oxidative stress, inflammation, and necroptosis, often leading to severe complications.
Hasan Camas +8 more
doaj +1 more source
Transcriptional regulation of PP2A-A alpha is mediated by multiple factors including AP-2alpha, CREB, ETS-1, and SP-1. [PDF]
PLoS ONE, 2009 Protein phosphatases-2A (PP-2A) is a major serine/threonine phosphatase and accounts for more than 50% serine/threonine phosphatase activity in eukaryotes.
He-Ge Chen +11 more
doaj +1 more source
Scientific Reports, 2021 Pseudomonas aeruginosa DN1 can efficiently utilize fluoranthene as its sole carbon source, and the initial reaction in the biodegradation process is catalyzed by a ring-hydroxylating dioxygenase (RHD).
Shu-Wen Xue +4 more
doaj +1 more source