Results 1 to 10 of about 2,088,392 (164)

Inherited/Genetically-Associated Pheochromocytoma/ Paraganglioma Syndromes and COVID-19

Medicina, 2021
In some subjects with inherited pheochromocytoma/paraganglioma (PPG) syndromes, hypoxia-inducible factor 1 alpha (HIF1α) stabilization/activation could lead to an increase in angiotensin converting enzymes (ACE).
Ioannis Ilias, Gregory Kaltsas, Konstantinos Barkas, George P. Chrousos   +3 more
doaj   +1 more source

Genetic epilepsy with febrile seizures plus – an overview [PDF]

Romanian Journal of Neurology, 2021
Genetic epilepsy with febrile seizures plus (GEFS+) is characterized by a group of genetic epilepsies associated predominately with an autosomal dominant pattern, but also with de novo and autosomal-recessive inheritance, these last two found in a small ...
Madalina Radu, Eugenia Roza, Daniel Mihai Teleanu, Raluca Ioana Teleanu   +3 more
doaj   +1 more source

The relationship between released soluble FceRI-alpha and its cell surface density on human basophils.

PLoS ONE, 2021
BackgroundThe IgE-mediated activation of mast cells and basophils results in the secretion of many substances, including the release of FceRI-alpha subunit.
Donald MacGlashan
doaj   +1 more source

A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization. [PDF]

PLoS ONE, 2016
The heteromeric membrane protein Organic Solute Transporter alpha/beta is the major bile acid efflux transporter in the intestine. Physical association of its alpha and beta subunits is essential for their polarized basolateral membrane localization and ...
Shuhua Xu, Carol J Soroka, An-Qiang Sun, Donald S Backos, Albert Mennone, Frederick J Suchy, James L Boyer   +6 more
doaj   +1 more source

Cannabidiol attenuates lung ischemia-reperfusion injury by modulating RIPK1/RIPK3-mediated necroptosis and HIF-1α/VEGF signaling [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Lung ischemia-reperfusion (IR) injury is a critical clinical condition characterized by oxidative stress, inflammation, and necroptosis, often leading to severe complications.
Hasan Camas, Mehtap Savran, Serap Yildirim, Suleyman Akin, Rasih Yazkan, Ilter Ilhan, Muhammet Tepebasi, Mehmet Sevuk, Ozlem Ozmen   +8 more
doaj   +1 more source

Transcriptional regulation of PP2A-A alpha is mediated by multiple factors including AP-2alpha, CREB, ETS-1, and SP-1. [PDF]

PLoS ONE, 2009
Protein phosphatases-2A (PP-2A) is a major serine/threonine phosphatase and accounts for more than 50% serine/threonine phosphatase activity in eukaryotes.
He-Ge Chen, Wen-Jun Han, Mi Deng, Jichao Qin, Dan Yuan, Jin-Ping Liu, Ling Xiao, Lili Gong, Songping Liang, Jian Zhang, Yun Liu, David Wan-Cheng Li   +11 more
doaj   +1 more source

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha.

Genes & Development, 1998
Hypoxia is an essential developmental and physiological stimulus that plays a key role in the pathophysiology of cancer, heart attack, stroke, and other major causes of mortality.
N. Iyer, L. Kotch, F. Agani, S. Leung, E. Laughner, R. Wenger, M. Gassmann, J. Gearhart, A. Lawler, A. Yu, G. Semenza   +10 more
semanticscholar   +1 more source

Binding interaction of a ring-hydroxylating dioxygenase with fluoranthene in Pseudomonas aeruginosa DN1

Scientific Reports, 2021
Pseudomonas aeruginosa DN1 can efficiently utilize fluoranthene as its sole carbon source, and the initial reaction in the biodegradation process is catalyzed by a ring-hydroxylating dioxygenase (RHD).
Shu-Wen Xue, Yue-Xin Tian, Jin-Cheng Pan, Ya-Ni Liu, Yan-Ling Ma   +4 more
doaj   +1 more source

The impact of spike mutated variants of SARS-CoV2 [Alpha, Beta, Gamma, Delta, and Lambda] on the efficacy of subunit recombinant vaccines

Brazilian Journal of Infectious Diseases, 2021
Since the first described human infection with SARS-CoV-2 in December of 2019 many subunit protein vaccines have been proposed for use in humans. Subunit vaccines use one or more antigens suitable for eliciting a robust immune response.
Mehrdad Mohammadi, Mohammad Shayestehpour, Hamed Mirzaei   +2 more
doaj   +1 more source

Transcriptome sequencing identifies genes associated with invasion of ovarian cancer

Journal of International Medical Research, 2020
Objective To identify key genes in ovarian cancer using transcriptome sequencing in two cell lines: MCV152 (benign ovarian epithelial tumour) and SKOV-3 (ovarian serous carcinoma).
Xiandong Peng, Min Yu, Jiazhou Chen
doaj   +1 more source