Results 21 to 30 of about 3,104,746 (304)

Analysis of Maxi-K alpha subunit splice variants in human myometrium

Reproductive Biology and Endocrinology, 2004
Background Large-conductance, calcium-activated potassium (Maxi-K) channels are implicated in the modulation of human uterine contractions and myometrial Ca2+ homeostasis.
Morrison John J, Curley Michael, Smith Terry J   +2 more
doaj   +1 more source

KCNE regulation of K+ channel trafficking – a Sisyphean task?

Frontiers in Physiology, 2012
Voltage-gated potassium (Kv) channels shape the action potentials of excitable cells and regulate membrane potential and ion homeostasis in excitable and nonexcitable cells.
Vikram Anmol Kanda, Geoffrey W Abbott, Geoffrey W Abbott   +2 more
doaj   +1 more source

Phylogenomic analyses reveal the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist. [PDF]

PLoS ONE, 2010
Transforming growth factor-beta (TGFbeta) homologues form a diverse superfamily that arose early in animal evolution and control cellular function through membrane-spanning, conserved serine-threonine kinases (RII and RI receptors).
Jie Zhu, Edward L Braun, Satomi Kohno, Monica Antenos, Eugene Y Xu, Robert W Cook, S Jack Lin, Brandon C Moore, Louis J Guillette, Theodore S Jardetzky, Teresa K Woodruff   +10 more
doaj   +1 more source

Liraglutide Enhances Cell Viability and Reduces Oxidative Stress in Hyperglycemic H9c2 Cardiomyocytes

Medicina
Background and Objectives: Cardiovascular disease remains a leading cause of mortality in Diabetes mellitus (DM), where chronic hyperglycemia induces oxidative stress, mitochondrial dysfunction, and hypoxia in cardiomyocytes.
Sinem Durmus, Zeki Dogan, Dilek Duzgun Ergun, Mahmut Ozdemir, Hakan Sahin, Gozde Erkanli Senturk, Remise Gelisgen, Hafize Uzun   +7 more
doaj   +1 more source

The α1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala

Frontiers in Behavioral Neuroscience, 2009
Synaptic plasticity in the amydgala is essential for emotional learning. Fear conditioning, for example, depends on changes in excitatory transmission that occur following NMDA receptor activation and AMPA receptor modification in this region. The role
Brian J Wiltgen, Brian J Wiltgen, Bill Godsil, Bill Godsil, Zechun Peng, Zechun Peng, Faysal Saab, Faysal Saab, Harry June, Michael L Van Linn, James M Cook, Carolyn Houser, Carolyn Houser, Thomas O’dell, Thomas O’dell, Gregg E Homanics, Michael Fanselow, Michael Fanselow   +17 more
doaj   +1 more source

Nitrile hydratase genes are present in multiple eukaryotic supergroups. [PDF]

PLoS ONE, 2012
Nitrile hydratases are enzymes involved in the conversion of nitrile-containing compounds into ammonia and organic acids. Although they are widespread in prokaryotes, nitrile hydratases have only been reported in two eukaryotes: the choanoflagellate ...
Alan O Marron, Michael Akam, Giselle Walker   +2 more
doaj   +1 more source

Set7-Mediated Repression of the HIF-1α Adaptive Response Triggers Apoptosis in Hypoxic Spermatogonia

Frontiers in Bioscience-Landmark
Background:Male infertility, often caused by oligospermia, is a major global health concern. Hypoxia is a known inducer of germ cell death, a process governed by the hypoxia-inducible factor 1α (HIF-1α).
Yangyang Song, Zhu Chen, Jieping Song, Jie Zheng   +3 more
doaj   +1 more source

Characterisation of the tryptophan synthase alpha subunit in maize

BMC Plant Biology, 2008
Background In bacteria, such as Salmonella typhimurium, tryptophan is synthesized from indole-3-glycerole phosphate (IGP) by a tryptophan synthase αββα heterotetramer.
Gierl Alfons, Frey Monika, Letzel Thomas, Fießelmann Andreas, Weigang Linda, Kriechbaumer Verena, Glawischnig Erich   +6 more
doaj   +1 more source

Wrapping the alpha-crystallin domain fold in a chaperone assembly [PDF]

, 2005
Small heat shock proteins (sHsps) are oligomers that perform a protective function by binding denatured proteins. Although ubiquitous, they are of variable sequence except for a C-terminal similar to 90-residue "alpha-crystallin domain".
Kappé, G., Boelens, W., Christine Slingsby, Slingsby, Christine, Guido Kappé, Wilbert Boelens, Stamler, R., Boelens, W.C., Slingsby, C, Robin Stamler   +9 more
core   +2 more sources

Serum Levels of MicroRNA-210 as a Pathogenic Factor in Patients with Diabetes and Diabetic Nephropathy: A Cross-sectional Study

Journal of Clinical and Diagnostic Research
Introduction: Diabetes Mellitus (DM) is a foremost global health challenge, causing disability and premature death. It leads to severe micro and macrovascular complications, including Diabetic Nephropathy (DN), which affects 20% of patients worldwide. Up
Divya Singh, Ivvala Anand Shaker, Ashishkumar Agravatt   +2 more
doaj   +1 more source