Results 21 to 30 of about 570,864 (312)

Generation of a PPP1CA knockout human pluripotent stem cell line via CRISPR/Cas9

Stem Cell Research, 2023
The Protein phosphatase 1 catalytic subunit alpha (PPP1CA) is a alpha subunit of the PP1 complex, which known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein ...
Xiaoman Wang, Jiaan Sun, Chong Fu, Chang Liu   +3 more
doaj   +1 more source

Analysis of Maxi-K alpha subunit splice variants in human myometrium

Reproductive Biology and Endocrinology, 2004
Background Large-conductance, calcium-activated potassium (Maxi-K) channels are implicated in the modulation of human uterine contractions and myometrial Ca2+ homeostasis.
Morrison John J, Curley Michael, Smith Terry J   +2 more
doaj   +1 more source

KCNE regulation of K+ channel trafficking – a Sisyphean task?

Frontiers in Physiology, 2012
Voltage-gated potassium (Kv) channels shape the action potentials of excitable cells and regulate membrane potential and ion homeostasis in excitable and nonexcitable cells.
Vikram Anmol Kanda, Geoffrey W Abbott, Geoffrey W Abbott   +2 more
doaj   +1 more source

Phylogenomic analyses reveal the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist. [PDF]

PLoS ONE, 2010
Transforming growth factor-beta (TGFbeta) homologues form a diverse superfamily that arose early in animal evolution and control cellular function through membrane-spanning, conserved serine-threonine kinases (RII and RI receptors).
Jie Zhu, Edward L Braun, Satomi Kohno, Monica Antenos, Eugene Y Xu, Robert W Cook, S Jack Lin, Brandon C Moore, Louis J Guillette, Theodore S Jardetzky, Teresa K Woodruff   +10 more
doaj   +1 more source

Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo. [PDF]

, 1995
The NPXY sequence is highly conserved among integrin beta subunit cytoplasmic tails, suggesting that it plays a fundamental role in regulating integrin-mediated function.
Brooks, PC, Cheresh, DA, Damsky, C, Deming, SL, Filardo, EJ   +4 more
core   +2 more sources

The α1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala

Frontiers in Behavioral Neuroscience, 2009
Synaptic plasticity in the amydgala is essential for emotional learning. Fear conditioning, for example, depends on changes in excitatory transmission that occur following NMDA receptor activation and AMPA receptor modification in this region. The role
Brian J Wiltgen, Brian J Wiltgen, Bill Godsil, Bill Godsil, Zechun Peng, Zechun Peng, Faysal Saab, Faysal Saab, Harry June, Michael L Van Linn, James M Cook, Carolyn Houser, Carolyn Houser, Thomas O’dell, Thomas O’dell, Gregg E Homanics, Michael Fanselow, Michael Fanselow   +17 more
doaj   +1 more source

Nitrile hydratase genes are present in multiple eukaryotic supergroups. [PDF]

PLoS ONE, 2012
Nitrile hydratases are enzymes involved in the conversion of nitrile-containing compounds into ammonia and organic acids. Although they are widespread in prokaryotes, nitrile hydratases have only been reported in two eukaryotes: the choanoflagellate ...
Alan O Marron, Michael Akam, Giselle Walker   +2 more
doaj   +1 more source

Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits [PDF]

, 2010
The rapidly activating and inactivating voltage-gated K(+) (Kv) current, I(A), is broadly expressed in neurons and is a key regulator of action potential repolarization, repetitive firing, backpropagation (into dendrites) of action potentials, and ...
Nerbonne, Jeanne M, Norris, Aaron J
core   +2 more sources

Liraglutide Enhances Cell Viability and Reduces Oxidative Stress in Hyperglycemic H9c2 Cardiomyocytes

Medicina
Background and Objectives: Cardiovascular disease remains a leading cause of mortality in Diabetes mellitus (DM), where chronic hyperglycemia induces oxidative stress, mitochondrial dysfunction, and hypoxia in cardiomyocytes.
Sinem Durmus, Zeki Dogan, Dilek Duzgun Ergun, Mahmut Ozdemir, Hakan Sahin, Gozde Erkanli Senturk, Remise Gelisgen, Hafize Uzun   +7 more
doaj   +1 more source

Serum Levels of MicroRNA-210 as a Pathogenic Factor in Patients with Diabetes and Diabetic Nephropathy: A Cross-sectional Study

Journal of Clinical and Diagnostic Research
Introduction: Diabetes Mellitus (DM) is a foremost global health challenge, causing disability and premature death. It leads to severe micro and macrovascular complications, including Diabetic Nephropathy (DN), which affects 20% of patients worldwide. Up
Divya Singh, Ivvala Anand Shaker, Ashishkumar Agravatt   +2 more
doaj   +1 more source