Results 1 to 10 of about 1,689 (175)
Zinc and Copper Ions Induce Aggregation of Human β-Crystallins
Molecules, 2022 Cataracts are defined as the clouding of the lens due to the formation of insoluble protein aggregates. Metal ions exposure has been recognized as a risk factor in the cataract formation process. The γ and β crystallins are members of a larger family and
Carlos Amero, Arline Fernández-Silva
exaly +4 more sources
Mollusc Crystallins: Physical and Chemical Properties and Phylogenetic Analysis
Diversity, 2022 The purpose of the present study was to perform bioinformatic analysis of crystallin diversity in aquatic molluscs based on the sequences in the NCBI Protein database.
Irina N. Dominova, Valery V. Zhukov
doaj +2 more sources
Protective Effects of Acetylation on the Pathological Reactions of the Lens Crystallins with Homocysteine Thiolactone. [PDF]
PLoS ONE, 2016 Various post-translational lens crystallins modifications result in structural and functional insults, contributing to the development of lens opacity and cataract disorders.
Zeinab Moafian +4 more
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Analysis of the cytoprotective role of α-crystallins in cell survival and implication of the αA-crystallin C-terminal extension domain in preventing Bax-induced apoptosis. [PDF]
PLoS ONE, 2013 α-Crystallins, initially described as the major structural proteins of the lens, belong to the small heat shock protein family. Apart from their function as chaperones, α-crystallins are involved in the regulation of intracellular apoptotic signals.
Séverine Hamann +3 more
doaj +1 more source
Frontiers in Pharmacology, 2022 C-kit/CD117, expressed in a series of tissue-specific progenitor cells, plays an important role in tissue regeneration and tissue homeostasis. We previously demonstrated that organoid-derived c-kit+ retinal progenitor cells can facilitate the restoration
Xi Chen +6 more
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Scientific Reports, 2021 Crystallins are ubiquitous, however, prevalence is seen in eye lens. Eye lens crystallins are long-lived and structural intactness is required for maintaining lens transparency and protein solubility. Mutations in crystallins often lead to cataract.
Sunita Patel, Ramakrishna V. Hosur
doaj +1 more source
Cells, 2022 In vitro differentiation of human pluripotent stem cells (hPSCs) into specialized tissues and organs represents a powerful approach to gain insight into those cellular and molecular mechanisms regulating human development.
Aleš Cvekl, Michael John Camerino
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βB1-crystallin: thermodynamic profiles of molecular interactions. [PDF]
PLoS ONE, 2012 β-Crystallins are structural proteins maintaining eye lens transparency and opacification. Previous work demonstrated that dimerization of both βA3 and βB2 crystallins (βA3 and βB2) involves endothermic enthalpy of association (∼8 kcal/mol) mediated by ...
Monika B Dolinska +2 more
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Frontiers in Pediatrics, 2022 AimsThe study aims to detect the underlying genetic defect in two autosomal dominant congenital cataract (ADCC) families.MethodsA detailed family history was collected, pedigrees were drawn, and slit-lamp examination and lens photography were performed ...
Vanita Vanita +4 more
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Crystalline Nephropathies [PDF]
Archives of Pathology & Laboratory Medicine, 2012 Context .—The kidney is a favored site for crystal deposition because of the high concentration of ions and molecules reached at the level of the renal tubules in the course of filtration. This review focuses on crystalline nephropathies in 4 broad categories: (1) dysproteinemia- associated, (2) drug-induced, (3)
Leal C, Herlitz +2 more
openaire +2 more sources