Results 31 to 40 of about 6,105 (219)
α-Crystallins in the Vertebrate Eye Lens: Complex Oligomers and Molecular Chaperones [PDF]
, 2021 α-Crystallins are small heat-shock proteins that act as holdase chaperones. In humans, αA-crystallin is expressed only in the eye lens, while αB-crystallin is found in many tissues.
Sprague-Piercy, Marc A +7 more
core +1 more source
BiomoleculesCataracts are diseases characterized by the opacity of the ocular lens and the subsequent deterioration of vision. Metal ions are one of the factors that have been reported to induce crystallin aggregation.
Reinier Cardenas +3 more
doaj +1 more source
Identification and functional analysis of αB-crystallins in Pteromalus puparum
Frontiers in Physiology, 2023 Heat shock proteins, including αB-crystallins (CRYAB), are pivotal in cellular defense mechanisms and stress response. This study presents a comprehensive investigation of heat shock proteins (HSPs), with a specific focus on the CRYAB family, within the ...
Shuxing Lao +3 more
doaj +1 more source
Crystalline and Non-crystalline Solids [PDF]
, 2016 The structural properties of materials play a fundamental role in the determination of their suitability for a specific application. This book is intended as a contribution to the efforts to increase the knowledge of the influence exerted on the properties of materials by their crystalline or amorphous structure. To this aim, some of the materials that
openaire +4 more sources
PLoS ONE, 2020 Parkinson´s disease is characterized by the accumulation of proteinaceous aggregates in Lewy bodies and Lewy Neurites. The main component found in such aggregates is α-synuclein.
Ricardo Gaspar +2 more
doaj +1 more source
An Insight on α-crystallin Interactions with Various Proteins in Systemic Disorders [PDF]
Journal of Stress Physiology & Biochemistry, 2023 αA- and αB- crystallins are the two principal components of the α-crystallin family of heat shock proteins which exhibit chaperone activity as well as cyto-protective function.
Aparajita Chakraborty +3 more
doaj
Intravitreal injection of β-crystallin B2 improves retinal ganglion cell survival in an experimental animal model of glaucoma. [PDF]
PLoS ONE, 2017 Purpose of this study was to investigate firstly specific proteomic changes within the retina in the course of an animal glaucoma model and to identify secondly new approaches for neuroprotective, therapeutic options in glaucoma by addressing those ...
Fabian Anders +8 more
doaj +1 more source
Advanced Science, EarlyView.The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Hui Chen +8 more
wiley +1 more source
Modifications of human βA1/βA3-crystallins include S-methylation, glutathiolation, and truncation [PDF]
, 2005 Disulfide bonding of lens crystallins contributes to the aggregation and insolubilization of these proteins that leads to cataract. A high concentration of reduced glutathione is believed to be key in preventing oxidation of crystallin sulfhydryls to ...
Cerny, Ronald +7 more
core +1 more source
Chilean science teachers' conceptualisations of disability when teaching students with autism
British Educational Research Journal, EarlyView.Abstract This study examines how Chilean secondary science teachers conceptualise disability when teaching students with autism in integrated classroom settings. Grounded in critical disability studies, the research employs a qualitative story‐completion method, using a fictional classroom scenario to prompt teachers to construct narratives that reveal
Alexis Gonzalez‐Donoso +1 more
wiley +1 more source