Results 31 to 40 of about 18,186 (212)

βB1-crystallin: thermodynamic profiles of molecular interactions. [PDF]

PLoS ONE, 2012
β-Crystallins are structural proteins maintaining eye lens transparency and opacification. Previous work demonstrated that dimerization of both βA3 and βB2 crystallins (βA3 and βB2) involves endothermic enthalpy of association (∼8 kcal/mol) mediated by ...
Monika B Dolinska, Paul T Wingfield, Yuri V Sergeev   +2 more
doaj   +1 more source

Molecular diagnosis of autosomal dominant congenital cataract in two families from North India reveals a novel and a known variant in GJA8 and GJA3

Frontiers in Pediatrics, 2022
AimsThe study aims to detect the underlying genetic defect in two autosomal dominant congenital cataract (ADCC) families.MethodsA detailed family history was collected, pedigrees were drawn, and slit-lamp examination and lens photography were performed ...
Vanita Vanita, Shiwali Goyal, Shailja Tibrewal, Shailja Tibrewal, Suma Ganesh   +4 more
doaj   +1 more source

Therapeutic Potential of α-Crystallins in Retinal Neurodegenerative Diseases

Antioxidants, 2021
The chaperone and anti-apoptotic activity of α-crystallins (αA- and αB-) and their derivatives has received increasing attention due to their tremendous potential in preventing cell death.
Ashutosh S. Phadte, Zachary B. Sluzala, Patrice E. Fort   +2 more
doaj   +1 more source

The human crystallin gene families

Human Genomics, 2012
Crystallins are the abundant, long-lived proteins of the eye lens. The major human crystallins belong to two different superfamilies: the small heat-shock proteins (α-crystallins) and the βγ-crystallins.
Wistow Graeme
doaj   +1 more source

Design and Characterization of Model Systems that Promote and Disrupt Transparency of Vertebrate Crystallins In Vitro

Advanced Science, 2023
Positioned within the eye, the lens supports vision by transmitting and focusing light onto the retina. As an adaptive glassy material, the lens is constituted primarily by densely‐packed, polydisperse crystallin proteins that organize to resist ...
Michael R. Bergman, Sophia A. Hernandez, Caitlin Deffler, Jingjie Yeo, Leila F. Deravi   +4 more
doaj   +1 more source

αA-crystallin peptide SDRDKFVIFLDVKHF accumulating in aging lens impairs the function of α-crystallin and induces lens protein aggregation. [PDF]

PLoS ONE, 2011
The eye lens is composed of fiber cells that are filled with α-, β- and γ-crystallins. The primary function of crystallins is to maintain the clarity of the lens through ordered interactions as well as through the chaperone-like function of α-crystallin.
Puttur Santhoshkumar, Murugesan Raju, K Krishna Sharma   +2 more
doaj   +1 more source

Dissimilarity in the Contributions of the N‑Terminal Domain Hydrophobic Core to the Structural Stability of Lens β/γ-Crystallins

, 2019
Vertebrate lens β/γ-crystallins share a conserved tertiary structure consisting of four Greek-key motifs divided into two globular domains. Numerous inherited mutations in β/γ-crystallins have been linked to cataractogenesis.
Wei-Jie Zhao (295923), Yong-Bin Yan, Kai Zhang, Wei-Jie Zhao, Yong-Bin Yan (295926), Ke Yao (47929), Ke Yao, Kai Zhang (102844)   +7 more
core   +2 more sources

Strain-independent increases of crystallin proteins in the retina of type 1 diabetic rats. [PDF]

PLoS ONE, 2013
Diabetic retinopathy is the leading cause of vision loss in working-age individuals in the United States and is expected to continue growing with the increased prevalence of diabetes. Streptozotocin-induced hyperglycemia in rats is the most commonly used
Erich A Heise, Lauren M Marozas, Sean A Grafton, Katelyn M Green, Stefanie J Kirwin, Patrice E Fort   +5 more
doaj   +1 more source

Analysis of the data on titration of native and peroxynitrite modified αA- and αB-crystallins by Cu2+-ions

Data in Brief, 2020
The interaction of αA- and αB-crystallins with Cu2+ ion modulates their structure and chaperone-like activity which is important for lens transparency. Theoretical analysis of the dependences of fluorescence intensity of native αA- and αB-crystallins and
Maryam Ghahramani, Reza Yousefi, Kazem Khoshaman, Sogand Sasan Moghadam, Boris Kurganov   +4 more
doaj   +1 more source

Alpha Crystallins in the Retinal Pigment Epithelium and Implications for the Pathogenesis and Treatment of Age-Related Macular Degeneration

Biochimica et Biophysica Acta, 2015
Background αA- and αB crystallins are principal members of the small heat shock protein family and elicit both a cell protective function and a chaperone function.
R. Kannan, P. Sreekumar, D. Hinton
semanticscholar   +1 more source