Results 21 to 30 of about 6,105 (219)
αA-crystallin peptide SDRDKFVIFLDVKHF accumulating in aging lens impairs the function of α-crystallin and induces lens protein aggregation. [PDF]
PLoS ONE, 2011 The eye lens is composed of fiber cells that are filled with α-, β- and γ-crystallins. The primary function of crystallins is to maintain the clarity of the lens through ordered interactions as well as through the chaperone-like function of α-crystallin.
Puttur Santhoshkumar +2 more
doaj +1 more source
, 2019 Vertebrate lens β/γ-crystallins share a conserved tertiary structure consisting of four Greek-key motifs divided into two globular domains. Numerous inherited mutations in β/γ-crystallins have been linked to cataractogenesis.
Wei-Jie Zhao (295923) +7 more
core +2 more sources
Strain-independent increases of crystallin proteins in the retina of type 1 diabetic rats. [PDF]
PLoS ONE, 2013 Diabetic retinopathy is the leading cause of vision loss in working-age individuals in the United States and is expected to continue growing with the increased prevalence of diabetes. Streptozotocin-induced hyperglycemia in rats is the most commonly used
Erich A Heise +5 more
doaj +1 more source
Data in Brief, 2020 The interaction of αA- and αB-crystallins with Cu2+ ion modulates their structure and chaperone-like activity which is important for lens transparency. Theoretical analysis of the dependences of fluorescence intensity of native αA- and αB-crystallins and
Maryam Ghahramani +4 more
doaj +1 more source
Proceedings of 31st International Symposium on Lattice Field Theory LATTICE 2013 — PoS(LATTICE 2013), 2014 We show that exotic phases arise in generalized lattice gauge theories known as quantum link models in which classical gauge fields are replaced by quantum operators. While these quantum models with discrete variables have a finite-dimensional Hilbert space per link, the continuous gauge symmetry is still exact.
Banerjee, Debasish +3 more
openaire +2 more sources
Concurrence of Danish dementia and cataract: insights from the interactions of dementia associated peptides with eye lens alpha-crystallin. [PDF]
PLoS ONE, 2008 Familial Danish Dementia (FDD) is an autosomal disease, which is distinguished by gradual loss of vision, deafness, progressive ataxia and dementia. Cataract is the first manifestation of the disease.
Ira Surolia +5 more
doaj +1 more source
Analysis and update of the human aldehyde dehydrogenase (
Human Genomics, 2005 The aldehyde dehydrogenase (ALDH) gene superfamily encodes enzymes that are critical for certain life processes and detoxification via the NAD(P)+-dependent oxidation of numerous endogenous and exogenous aldehyde substrates, including pharmaceuticals and
Vasiliou Vasilis, Nebert Daniel W
doaj +1 more source
Multiple aggregates and aggresomes of C-terminal truncated human αA-crystallins in mammalian cells and protection by αB-crystallin. [PDF]
PLoS ONE, 2011 Cleavage of 11 (αA162), 5 (αA168) and 1 (αA172) residues from the C-terminus of αA-crystallin creates structurally and functionally different proteins. The formation of these post-translationally modified αA-crystallins is enhanced in diabetes.
Ilangovan Raju +2 more
doaj +1 more source
Cataract-causing defect of a mutant γ-crystallin proceeds through an aggregation pathway which bypasses recognition by the α-crystallin chaperone. [PDF]
PLoS ONE, 2012 The transparency of the eye lens depends upon maintenance of the native state of the γ- and β-crystallins, which is aided by the abundant chaperones αA- and αB-crystallin.
Kate L Moreau, Jonathan A King
doaj +1 more source
, 2007 Experimental autoimmune uveitis (EAU) is a well-known animal model of posterior uveitis that is one of the major causes of blindness. EAU could be induced in susceptible animals (i.e., Lewis rat) by immune reactions using evolutionarily conserved retinal
Hun-Taeg Chung (583329) +8 more
core +3 more sources