Results 21 to 30 of about 18,186 (212)
Characterization of the Interaction of Human γS Crystallin with Metal Ions and Its Effect on Protein Aggregation [PDF]
BiomoleculesCataracts are diseases characterized by the opacity of the ocular lens and the subsequent deterioration of vision. Metal ions are one of the factors that have been reported to induce crystallin aggregation.
Reinier Cardenas +3 more
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G91-deletion in βA3/A1-crystallin induces cellular and molecular changes in mouse lenses leading to congenital cataract development. [PDF]
PLoS ONECRYβA1-ΔG91 (βA3ΔG91) is a mutational hotspot in CRYβA1, which causes autosomal dominant congenital nuclear cataract in humans and mice. Previous in-vitro studies of recombinant βA3ΔG91 showed defective folding, decreased solubility, and aberrant ...
Akosua K Boateng +2 more
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Interaction of βA3-Crystallin with Deamidated Mutants of αA- and αB-Crystallins.
PLoS ONE, 2015 Interaction among crystallins is required for the maintenance of lens transparency. Deamidation is one of the most common post-translational modifications in crystallins, which results in incorrect interaction and leads to aggregate formation.
Ekta Tiwary +4 more
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Evolution of crystallins for a role in the vertebrate eye lens
Protein Science, 2013 The camera eye lens of vertebrates is a classic example of the re-engineering of existing protein components to fashion a new device. The bulk of the lens is formed from proteins belonging to two superfamilies, the α-crystallins and the βγ-crystallins ...
C. Slingsby, G. Wistow, Alice R. Clark
semanticscholar +2 more sources
Analysis of the cytoprotective role of α-crystallins in cell survival and implication of the αA-crystallin C-terminal extension domain in preventing Bax-induced apoptosis. [PDF]
PLoS ONE, 2013 α-Crystallins, initially described as the major structural proteins of the lens, belong to the small heat shock protein family. Apart from their function as chaperones, α-crystallins are involved in the regulation of intracellular apoptotic signals.
Séverine Hamann +3 more
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Corneal crystallins and the development of cellular transparency
Seminars in Cell and Developmental Biology, 2008 James V Jester
exaly +2 more sources
Frontiers in Pharmacology, 2022 C-kit/CD117, expressed in a series of tissue-specific progenitor cells, plays an important role in tissue regeneration and tissue homeostasis. We previously demonstrated that organoid-derived c-kit+ retinal progenitor cells can facilitate the restoration
Xi Chen +6 more
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Function and aggregation in structural eye lens crystallins
Accounts of Chemical Research, 2020 Conspectus Crystallins are transparent, refractive proteins that contribute to the focusing power of the vertebrate eye lens. These proteins are extremely soluble, resisting aggregation for decades, even under crowded conditions. Crystallins have evolved
K. Roskamp +3 more
semanticscholar +1 more source
Scientific Reports, 2021 Crystallins are ubiquitous, however, prevalence is seen in eye lens. Eye lens crystallins are long-lived and structural intactness is required for maintaining lens transparency and protein solubility. Mutations in crystallins often lead to cataract.
Sunita Patel, Ramakrishna V. Hosur
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Cells, 2022 In vitro differentiation of human pluripotent stem cells (hPSCs) into specialized tissues and organs represents a powerful approach to gain insight into those cellular and molecular mechanisms regulating human development.
Aleš Cvekl, Michael John Camerino
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