Results 11 to 20 of about 1,689 (175)
The Effect of Attractive Interactions and Macromolecular Crowding on Crystallins Association. [PDF]
PLoS ONE, 2016 In living systems proteins are typically found in crowded environments where their effective interactions strongly depend on the surrounding medium. Yet, their association and dissociation needs to be robustly controlled in order to enable biological ...
Jiachen Wei +3 more
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Interaction of βA3-Crystallin with Deamidated Mutants of αA- and αB-Crystallins.
PLoS ONE, 2015 Interaction among crystallins is required for the maintenance of lens transparency. Deamidation is one of the most common post-translational modifications in crystallins, which results in incorrect interaction and leads to aggregate formation.
Ekta Tiwary +4 more
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The Functional Significance of High Cysteine Content in Eye Lens γ-Crystallins
BiomoleculesCataract disease is strongly associated with progressively accumulating oxidative damage to the extremely long-lived crystallin proteins of the lens. Cysteine oxidation affects crystallin folding, interactions, and light-scattering aggregation especially
Eugene Serebryany +2 more
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Therapeutic Potential of α-Crystallins in Retinal Neurodegenerative Diseases
Antioxidants, 2021 The chaperone and anti-apoptotic activity of α-crystallins (αA- and αB-) and their derivatives has received increasing attention due to their tremendous potential in preventing cell death.
Ashutosh S. Phadte +2 more
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Science, 1937 Sumner, James B. and Dounce, Alexander L. Crystalline Catalase, 1937 ; https://digitalcommons.rockefeller.edu/pamphlets-offprints-and-reprints/1045/thumbnail ...
Sumner, James B., Dounce, Alexander L.
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The human crystallin gene families
Human Genomics, 2012 Crystallins are the abundant, long-lived proteins of the eye lens. The major human crystallins belong to two different superfamilies: the small heat-shock proteins (α-crystallins) and the βγ-crystallins.
Wistow Graeme
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Advanced Science, 2023 Positioned within the eye, the lens supports vision by transmitting and focusing light onto the retina. As an adaptive glassy material, the lens is constituted primarily by densely‐packed, polydisperse crystallin proteins that organize to resist ...
Michael R. Bergman +4 more
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αA-crystallin peptide SDRDKFVIFLDVKHF accumulating in aging lens impairs the function of α-crystallin and induces lens protein aggregation. [PDF]
PLoS ONE, 2011 The eye lens is composed of fiber cells that are filled with α-, β- and γ-crystallins. The primary function of crystallins is to maintain the clarity of the lens through ordered interactions as well as through the chaperone-like function of α-crystallin.
Puttur Santhoshkumar +2 more
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Science, 1929 A method is described for the preparation of a crystalline protein from commercial pepsin preparations which has powerful peptic activity. The composition, optical activity, and proteolytic activity of this protein remain constant through seven successive crystallizations.
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, 2019 Vertebrate lens β/γ-crystallins share a conserved tertiary structure consisting of four Greek-key motifs divided into two globular domains. Numerous inherited mutations in β/γ-crystallins have been linked to cataractogenesis.
Wei-Jie Zhao (295923) +7 more
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