Zinc and Copper Ions Induce Aggregation of Human β-Crystallins
Molecules, 2022 Cataracts are defined as the clouding of the lens due to the formation of insoluble protein aggregates. Metal ions exposure has been recognized as a risk factor in the cataract formation process. The γ and β crystallins are members of a larger family and
Arline Fernández-Silva, CARLOS Amero
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Functions of crystallins in and out of lens: Roles in elongated and post-mitotic cells
Progress in Biophysics and Molecular Biology, 2014 The vertebrate lens evolved to collect light and focus it onto the retina. In development, the lens grows through massive elongation of epithelial cells possibly recapitulating the evolutionary origins of the lens.
Christine Slingsby
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The Functional Significance of High Cysteine Content in Eye Lens γ-Crystallins [PDF]
BiomoleculesCataract disease is strongly associated with progressively accumulating oxidative damage to the extremely long-lived crystallin proteins of the lens. Cysteine oxidation affects crystallin folding, interactions, and light-scattering aggregation especially
Eugene Serebryany +2 more
doaj +3 more sources
Ageing and vision: structure, stability and function of lens crystallins
Progress in Biophysics and Molecular Biology, 2004 Contains fulltext : 57972.pdf (Publisher’s version ) (Closed access)The alpha-, beta- and gamma-crystallins are the major protein components of the vertebrate eye lens, alpha-crystallin as a molecular chaperone as well as a structural ...
Hans Bloemendal +2 more
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Mollusc Crystallins: Physical and Chemical Properties and Phylogenetic Analysis
Diversity, 2022 The purpose of the present study was to perform bioinformatic analysis of crystallin diversity in aquatic molluscs based on the sequences in the NCBI Protein database.
Irina N. Dominova, Valery V. Zhukov
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Protective Effects of Acetylation on the Pathological Reactions of the Lens Crystallins with Homocysteine Thiolactone. [PDF]
PLoS ONE, 2016 Various post-translational lens crystallins modifications result in structural and functional insults, contributing to the development of lens opacity and cataract disorders.
Zeinab Moafian +4 more
doaj +2 more sources
Lens β-crystallins: The role of deamidation and related modifications in aging and cataract
Progress in Biophysics and Molecular Biology, 2014 Crystallins are the major proteins in the lens of the eye and function to maintain transparency of the lens. Of the human crystallins, α, β, and γ, the β-crystallins remain the most elusive in their structural significance due to their greater number of ...
Kirsten J Lampi +2 more
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Zebrafish as a model for crystallin-associated congenital cataracts in humans [PDF]
Frontiers in Cell and Developmental BiologyCongenital cataracts are a leading cause of vision loss in children and can be an isolated finding or associated with systemic abnormalities. Isolated congenital cataracts are most commonly associated with pathogenic variants in one of the Crystallin ...
Jennifer L. Rossen +5 more
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The Effect of Attractive Interactions and Macromolecular Crowding on Crystallins Association. [PDF]
PLoS ONE, 2016 In living systems proteins are typically found in crowded environments where their effective interactions strongly depend on the surrounding medium. Yet, their association and dissociation needs to be robustly controlled in order to enable biological ...
Jiachen Wei +3 more
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α-Crystallins in the Vertebrate Eye Lens: Complex Oligomers and Molecular Chaperones. [PDF]
Annual review of physical chemistry (Print), 2020 α-Crystallins are small heat-shock proteins that act as holdase chaperones. In humans, αA-crystallin is expressed only in the eye lens, while αB-crystallin is found in many tissues.
Marc A. Sprague-Piercy +3 more
semanticscholar +2 more sources