Results 11 to 20 of about 5,582 (218)
The Effect of Attractive Interactions and Macromolecular Crowding on Crystallins Association. [PDF]
PLoS ONE, 2016 In living systems proteins are typically found in crowded environments where their effective interactions strongly depend on the surrounding medium. Yet, their association and dissociation needs to be robustly controlled in order to enable biological ...
Jiachen Wei +3 more
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Interaction of βA3-Crystallin with Deamidated Mutants of αA- and αB-Crystallins. [PDF]
PLoS ONE, 2015 Interaction among crystallins is required for the maintenance of lens transparency. Deamidation is one of the most common post-translational modifications in crystallins, which results in incorrect interaction and leads to aggregate formation.
Ekta Tiwary +4 more
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Dissimilarity in the Contributions of the N‑Terminal Domain Hydrophobic Core to the Structural Stability of Lens β/γ-Crystallins [PDF]
, 2019 Vertebrate lens β/γ-crystallins share a conserved tertiary structure consisting of four Greek-key motifs divided into two globular domains. Numerous inherited mutations in β/γ-crystallins have been linked to cataractogenesis.
Wei-Jie Zhao (295923) +7 more
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Cells, 2022 In vitro differentiation of human pluripotent stem cells (hPSCs) into specialized tissues and organs represents a powerful approach to gain insight into those cellular and molecular mechanisms regulating human development.
Aleš Cvekl, Michael John Camerino
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βB1-crystallin: thermodynamic profiles of molecular interactions. [PDF]
PLoS ONE, 2012 β-Crystallins are structural proteins maintaining eye lens transparency and opacification. Previous work demonstrated that dimerization of both βA3 and βB2 crystallins (βA3 and βB2) involves endothermic enthalpy of association (∼8 kcal/mol) mediated by ...
Monika B Dolinska +2 more
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Frontiers in Pediatrics, 2022 AimsThe study aims to detect the underlying genetic defect in two autosomal dominant congenital cataract (ADCC) families.MethodsA detailed family history was collected, pedigrees were drawn, and slit-lamp examination and lens photography were performed ...
Vanita Vanita +4 more
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Crystalline Nephropathies [PDF]
Archives of Pathology & Laboratory Medicine, 2012 Context .—The kidney is a favored site for crystal deposition because of the high concentration of ions and molecules reached at the level of the renal tubules in the course of filtration. This review focuses on crystalline nephropathies in 4 broad categories: (1) dysproteinemia- associated, (2) drug-induced, (3)
Leal C, Herlitz +2 more
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Therapeutic Potential of α-Crystallins in Retinal Neurodegenerative Diseases
Antioxidants, 2021 The chaperone and anti-apoptotic activity of α-crystallins (αA- and αB-) and their derivatives has received increasing attention due to their tremendous potential in preventing cell death.
Ashutosh S. Phadte +2 more
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Science, 1937 Sumner, James B. and Dounce, Alexander L. Crystalline Catalase, 1937 ; https://digitalcommons.rockefeller.edu/pamphlets-offprints-and-reprints/1045/thumbnail ...
Sumner, James B., Dounce, Alexander L.
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The human crystallin gene families
Human Genomics, 2012 Crystallins are the abundant, long-lived proteins of the eye lens. The major human crystallins belong to two different superfamilies: the small heat-shock proteins (α-crystallins) and the βγ-crystallins.
Wistow Graeme
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