Results 11 to 20 of about 8,792 (226)
The human crystallin gene families [PDF]
Human Genomics, 2012 Crystallins are the abundant, long-lived proteins of the eye lens. The major human crystallins belong to two different superfamilies: the small heat-shock proteins (α-crystallins) and the βγ-crystallins.
Wistow Graeme
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The Effect of Attractive Interactions and Macromolecular Crowding on Crystallins Association. [PDF]
PLoS ONE, 2016 In living systems proteins are typically found in crowded environments where their effective interactions strongly depend on the surrounding medium. Yet, their association and dissociation needs to be robustly controlled in order to enable biological ...
Jiachen Wei +3 more
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In vivo substrates of the lens molecular chaperones αA-crystallin and αB-crystallin. [PDF]
PLoS ONE, 2014 αA-crystallin and αB-crystallin are members of the small heat shock protein family and function as molecular chaperones and major lens structural proteins.
Usha P Andley +2 more
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Cells, 2022 In vitro differentiation of human pluripotent stem cells (hPSCs) into specialized tissues and organs represents a powerful approach to gain insight into those cellular and molecular mechanisms regulating human development.
Aleš Cvekl, Michael John Camerino
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βB1-crystallin: thermodynamic profiles of molecular interactions. [PDF]
PLoS ONE, 2012 β-Crystallins are structural proteins maintaining eye lens transparency and opacification. Previous work demonstrated that dimerization of both βA3 and βB2 crystallins (βA3 and βB2) involves endothermic enthalpy of association (∼8 kcal/mol) mediated by ...
Monika B Dolinska +2 more
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Frontiers in Pediatrics, 2022 AimsThe study aims to detect the underlying genetic defect in two autosomal dominant congenital cataract (ADCC) families.MethodsA detailed family history was collected, pedigrees were drawn, and slit-lamp examination and lens photography were performed ...
Vanita Vanita +4 more
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Angewandte Chemie, 2020 AbstractBoragermene 3 featuring a double bond between the Ge and dicoordinate B atoms has been synthesized for the first time by reacting the cyclic (alkyl)(boryl)germylene–PMe3 adduct 1 with Cl2BN(SiMe3)2 followed by reductive dehalogenation with KC8.
Bin Rao, Rei Kinjo
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Proceedings of 31st International Symposium on Lattice Field Theory LATTICE 2013 — PoS(LATTICE 2013), 2014 We show that exotic phases arise in generalized lattice gauge theories known as quantum link models in which classical gauge fields are replaced by quantum operators. While these quantum models with discrete variables have a finite-dimensional Hilbert space per link, the continuous gauge symmetry is still exact.
Banerjee D. +3 more
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Therapeutic Potential of α-Crystallins in Retinal Neurodegenerative Diseases
Antioxidants, 2021 The chaperone and anti-apoptotic activity of α-crystallins (αA- and αB-) and their derivatives has received increasing attention due to their tremendous potential in preventing cell death.
Ashutosh S. Phadte +2 more
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New insight into cataract formation -- enhanced stability through mutual attraction [PDF]
, 2007 Small-angle neutron scattering experiments and molecular dynamics simulations combined with an application of concepts from soft matter physics to complex protein mixtures provide new insight into the stability of eye lens protein mixtures.
A. Stradner +12 more
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